It's hard to say exactly "That Its time to pick up and leave. Because for me personally it's been a long hard road with building hubs writing and the amount of time and effort that's went into everything for me personally to just get up and go but sad to say "it is".
The Algorithm that googles put out has really changed everything my hubs traffic has dropped by 67% and continues to drop daily so i'm seeing numbers as if I just joined Hubpages and starting from the get go. Many will say "Well your hubs aren't good enough" well they are and if anything there loaded with content so I started working on other projects.
*Tumblr.com Offers you amazing Layouts and you can write blog posts and make your own URL like Blogger.com but with Tumblr Google seems to put these blogs up higher than their own Blogger.com
*eHow.com which now REINS supreme when it comes to keywords hubpage hubbers use to dominate so eHow's looking pretty good.
*Make Your Own Website
Basically Content is still king as it always will be you just have to write your heart out for the Keywords or whatever it is your passionate about. For me my social Gaming Blog: http://Socialgaming.tumblr.com was started a month ago and is PR 1,3, and 4 for certain keywords and is indexed so i'm going to focus on that for now and see how things go and let my writing on here die down because Google has killed a lot of hubbers hubs.