Absolutely yes. I have had typos pointed out and I really appreciate it. In fact, Hubpages recommends this. I believe hubbers are able to delete that part of the comment anyway, if they wish.
Perhaps some writers are more sensitive, but as long as no one is mean or blatantly rude about my errors, then I see no problem with pointing out typos, etc. Also, you'll probably get a sense for who can accept this sort of help and who might feel resentful. Best to leave the resentful one's to their mistakes, unfortunately.