Bioinformatics Part II
Here's the next part of my talk from this summer, in the form of powerpoint slides with commentary:
According to Tomkins, a major problem with nearly all past human-chimp comparative DNA studies is that data often goes through several levels of pre-screening, filtering and selection before being aligned, summarized, and discussed. Non-alignable regions are typically omitted and gaps in alignments are often discarded.
Check out Entrez's help page for a description of the service.
Entrez offers a really neat tool! Take a look at the BLAST homepage, and click on "more" to see a description.
Here we've aligned the human and chimpanzee versions of the PAX3 gene. The image above represents the screen that appears when the BLAST tool is done. The two sequences have 100% identity, meaning that they align perfectly.
Watch for the next post, in which I will demonstrate another database, called Genome Browser. We'll go back over BLAST as well.