What the MTHFR is My DNA Mutation
I am a mutant! At age 64 I found out I have a mutation in my DNA called MTHFR. I heard about it on facebook from a friend. She listed the symptoms and they sounded too much like mine. So, having had a brain scan recently, I knew I did not have a stroke, and there were no tumors in my brain. I asked my doctor if I could have a blood test to check for MTHFR DNA mutation. When the results came, I was grateful someone had listened to me.
The Methylation Miracle
All my life I have felt a bit out-of-sync with the rest of the humans I have lived around. As a child, I was well known for my temper which usually resulted in my running to my bedroom, slamming the door and being alone for several hours. I eventually came out of my room, acting as if nothing had happened. I have dealt with depression for much of my life, at certain times severe.
My friend posted on facebook about a MTHFR Gene Mutation and the more I read, the more I related to the symptoms. It definitely piqued my curiosity, and I read all I could find about it. It seems like a fairly new discovery and not many doctors are aware of it. My doctor ran a blood test to check if I had the mutation. MTHFR stands for Methylenetetrahydrofolate Reductase.
According to MTHFR.net, the MTHFR gene mutation is a highly significant pubic health problem that is almost completely ignored. Millions suffer from addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer and autism and pulmonary embolisms, just to name a few conditions which are linked to the MTHFR gene mutation.
My mutation is heterozygous A1298C. There is also a C677T which seems to get more attention, but I found that symptoms associated with MTHFR mutations include: brain fog, headache, memory loss, hand tremors, chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, insomnia, muscle pain, delayed speech and hypertension. Signs that point to a mutation are decrease in seratonin, dopamine, epinephrine and norepinephrine, ulcers, pre-eclampsia and elevated blood pressure amongst others.
My own symptoms included insomnia, depression, speech delay, inability to deal with stress and muscle pain. Last year I had shingles. I am glad that my doctor agreed to do the blood test. Although I have been taking medication for some time for each of these conditions, they have not been resolved. Two of my sisters also have similar symptoms and suffer, so I suggested that they have the test too.
Those with A1298C may have methylation issues which lead to increased toxicity. I was prescribed a medical food called Deplin. It is quite new, so it is very expensive, but I feel it is worth it.
With MTHFR, it is difficult for me to process amino acid homocysteine to amino acid, methionine.
Have you ever heard of MTHFR?
I would love to hear from you if you have had experience with MTHFR, especially A1298C heterozygous. Share with us so we can help others with this mutation. Now I am on a mission to find out others in my family who may have the same mutation.
Fellow hubber - same subject
- MTHFR Mutations
Finding out I had a MTHFR mutation saved the life of my son. Knowing sooner would have saved my preemie son and daughter. Can you afford to not know about this common gene mutation?
© 2015 Elayne