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Proteomics & Bioinformatics Game Changers in Modern Medicine

Updated on June 30, 2016

Proteomics & Bioinformatics

Proteomics - Bioinformatics

Proteins are one of the most important structural and functional components of living organisms and they play a vital role in all the metabolic processes. Proteomics is the study of protein structures and functions by using computers and software tools. ‘Proteomics’ word was coined by Marc Wilkins in 1994 and accepted in 1997with analogy to genomics, which is the study of genome. Actually the proteome refers to the entire set of proteins produced or modified in an organism or cell. Proteomics is now an emerging discipline and is an important component of functional genomics.

Another recently emerged important discipline is Bioinformatics. It is an interdisciplinary field that develops methods, softwares and tools for assessing biological data. It is the combination of Computer science, engineering, mathematics and statistics. It is the main source and hope for development of personalized nanomedicine and future advancements in medicine.

Journal of Proteomics & Bioinformatics is a prestigious peer reviewed international journal focused on publishing discoveries and current developments regarding Bioinformatics tools, Protein Biochemistry, Proteomes, Translational modifications, Amino acid sequencing, etc. This Open Access journal provides a good platform for the scientists and researchers to publish their remarkable findings which help the aspiring scholars in this field by providing the content online worldwide without any subscriptions charges.

Scientific articles regarding Mass Spectrometry, Metabolomics, Data Mining, Genomics, Translational proteomics, Epigenomics, Pharmacogenomics, Pharmacoproteomics, Proteomics Clinical applications, Cancer Biomarkers, Open Biomarkers, Transcriptomics, Molecular and Cellular Proteomics, Proteomes, Human Genomics and Proteomics, were also given high importance for publication.

Articles with highly advanced scientific content are given high priority for publication, for example an article which describes Microbial Carboxylesterases role in thermal adaptation using In Silico approach. Actually Carboxylesterases catalyze the hydrolysis of carboxylic ester molecule in the presence of water to form alcohol and carboxylic acid. Authors did in silico analysis of ten carboxylesterases (E.C. 3.1.1.1) sequences from two groups of organisms mesophilic and thermophilic for various physiochemical parameters and amino acid sequence comparison. They found phylogenetic relationship between the two groups using maximum parsimony method of MEGA-6. They further analyzed the carboxylesterases, using online ProtParam ExPASy tool for other physicochemical properties and also they detected the presence of conserved catalytic triad S157, D254, H284 with the help of multiple sequence alignment (MSA). They observed that the two groups of enzymes showed significant variation in their physical and chemical properties. They found that esterases affinity for water soluble short chain fatty esters is due to the Polar amino acid residues such as Gln (Q), Asn (N), Cys (C) Lys (K), Thr (T) and Glu (D) and these helps to distinguish lipases from esterases for their affinity. They concluded that because of the affinity of polar amino acids to water molecules, they have the tendency to be on the exterior side of the protein which enables them to interact with Polar Regions on the bio-surfaces.

To publish articles on the topics like Proteomic Analysis, Protein sequence analysis, Proteomics Clinical Applications, Cancerous proteins, etc., Open Access Journal of Proteomics & Bioinformatics is of the best option.

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