The muscles in the human body have adapted to suit the gravitational force of Earth. With the gravity on Mars being 1/3rd that of Earth, how do you think the body will evolve?
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Astronauts, spending 3 months in space often are stretchered away when they land and spend time recovering from muscle loss. I would imagine the longer they are subject to low or zero gravity the harder it would be to return.
Agreed, but 0.38g is very different from zero G. There is probably some threshold of gravity level that will allow the human body to remain easily adaptable to greater gravities. We'll never know until we try!