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Did you mean most dastardly, cruelist, damnable" ?
The "biggest" was probably Nero, of ancient Rome. I believe he "topped the scales" at some 400 lbs, and he certainly earns the classification of "a time-honored villain".
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Mao and Adolf are right there on the top. Although I have seen some researches that show Mao Tsetung was responsible for the most deaths in human history.
This system won't let me post a short answer, all I wanted to say is:
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