It's an intriguing matchup. However, given how quickly Borg are known to adapt their technology to a given battle situation I have to give them the edge. Star Destroyers don't have much complexity to their weapons and rely on overpowering force. The Borg have no fear of that since they can easily find ways around a problem. I give this one to the Cube.
You can help the HubPages community highlight top quality content by ranking this answer up or down.