It is for sure. You can clean and clean and clean all you want but soon enough it will get messy and unorganized again! It is because it takes so long to organize that there are somethings that just kinda get over looked and put neatly somewhere else. When you want it to be organized and final you have to look over everything and be prepared to throw out a lot of stuff. I threw out so much stuff when I finally organized my office and it actually felt good "less clutter" Before I would have kept it and looked over it later. Then consider later when you have to keep everything organized. Buy folders and baskets for certain things like I have a folder organized for months with mail I should hold onto for my records.
Also when I am at work I made up my own system. I organized it according to what function the papers serve and what order I have to do things in. I user sticky notes A LOT even if I think I would remember what is special about that certain thing.
A few months ago I was a disorganized mess!