One of my best friends is a direct descendant of Henry Wadsworth Longfellow. When he told me, I flipped a little. He admitted he had to Google him when he found out, though.
This is interesting, too. A friend of mine from college is a direct descendant of Myles Standish.
But the only interesting thing I can think of in my family is a great aunt who is a fortune teller in the New Orleans French Quarter....