Is it Elliot Salem and Tyson Rios from the Army of Two series...or maybe even Billy and Jimmy Lee from Double Dragon...or what about Lance Bean was Bill Rizer from Contra...or Colonel Ralf and Second Lieutenant Clark (aka Paul and Vince) of Ikari Warriors fame...or the more traditional choice Mario and Luigi the Mario Bros? Of course you don't have to be blood to be a bro...everyone knows that...but if you do happen to be blood and a hoe...then that would make you a redneck...not hating just saying.
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They were some serious donkey kickers...weren't they?
Ask Luigi if he feels like he's part of the greatest bros in video games...I'm sure he would love to knock Mario off so he could get some love...he probably feels like Robert from Everybody Love Raymond.