There have been a lot of memorable women to headline their own video games. Lara Croft from the Tomb Raider series, Samus Aran from the Metroid series, Jade from Beyond Good and Evil. But, which one is your favorite?
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I second Elizabeth. The Booker Dewitt/Elizabeth dynamic is what makes Bioshock Infinite amazing. Plus the added bonus of stepping into her shoes in the Burial at Sea DLC is incredible.
Clementine is a good choice.