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Drug Company Destroyed Files - Agrees to Settlement

Updated on October 17, 2015
brakel2 profile image

A medical background and interest in research created Audrey Selig's interest in writing about medical issues.

Takeda Offers to Settle Bladder Cancer Lawsuits for $2.4 Billion Dollars

Takeda Pharmaceutical, after losing money on individual cases, has finally agreed, as of April 29, 2015, to settle the class action lawsuits over its actos drug. The settlement remains pending, as attorneys believe plaintiffs deserve more money for becoming bladder cancer victims. This is a victory for the attorneys in the United States where the lawsuits were filed.


Takeda Destroys Files

Takeda Pharmaceuticals in January 2014 admitted it deliberately destroyed documents regarding the development, marketing, and sales of the drug Actos. Lawsuits, including class actions, have been filed over the past few years claiming the drug caused bladder cancer in patients. The judge has meted out the punishment to the company of explaining this destruction of evidence to the jury, which is now hearing cases.

Success against Takeda

As of early 2015, Takeda has paid millions in five individual cases and punitive fines. Experts now believe the company should set aside money to settle the numerous pending class action cases.

Prior Updates

UPDATE Judgement awarded to California man overturned by judge.` April 2013 Drug Attorney fights first case of California man who has three months to live, saying he was a high risk for bladder cancer. Man awarded $6.5 million in May 2013 March 2012 A lawsuit has been filed by whistleblower Helen Ge, a former reviewer for Takeda Pharmaceuticals. It has recently been unsealed and indicates the drug company told reviewers to conceal information about Actos and bladder cancer and Actos and heart disease. This information should help the victim lawsuits over actors. UPDATE August 2011 Lawsuit filed by my husband which will be part of a class action lawsuit. JUNE 2011 - The FDA is placing a warning on Actos that it may cause bladder cancer. France and Germany have banned the drug. Victims are filing lawsuits. Watch for more updates.

Side Effects of Medication

Actos and Bladder Cancer linked
Actos and Bladder Cancer linked | Source

Definite Link Between Drug Actos and Bladder Cancer

FDA announcement about possible link

On September 17, 2010. The FDA announced “the drug Actos for diabetes may be linked to a higher risk for bladder cancer and warrants further study”. This information. based on two 10-year case studies,still ongoing, also indicated that, in preclinical trials. male rats developed bladder tumors.. Victims received instructions in the news article to contact the FDA about any adverse reactions from Actos.and to contact physicians for any further recommendations. provides information along with other medical websites.The hotline FDA number is1-800-FDA-0178.

History of Actos and Avandia

Actos has a black box warning, stating that heart failure and liver disease patients should avoid the drug. There are numerous other side effects shown at the website of WebMD. Bladder cancer is not mentioned.The drug was introduced in 1999 to help diabetes patients by reducing insulin resistance.The drug is also called Pioglitazone and along with the drug, Avandia, is in a class called thiazolidenidione medications

Avandia is the only other drug in the same family as actos, and evidence shows increased cardiac risk for that diabetes drug. As of 9/23/10, the FDA has placed limits on that drug. Patients must sign a release form stating that they understand the risks of the drug. New patients cannot take the drug unless another diabetes drug has not been successful. Some patients who were on Avandia have already filed lawsuits based on cardiac problems

Some People are Cured

Info on Consumer Groups

Consumer groups" concerns

Many consumer groups have advocated more stringent monitoring by the FDA before drug approval. Many of the drug companies spend money on marketing drugs with TV ads and other methods. At one time in the past, this type of marketing was very limited. Consumer groups advocate a critical need for adequate money for research to make drugs safer and find new drugs.


Drugs are good and sometimes deadly. The FDA attempts to do a good job, but often politics and money become influential in the decisions. The drug companies could improve the situation by spending more money on research and reporting findings honestly, without cover-ups. At least, consumer groups work diligently to ensure better results. Everyone needs to join hands and fight for better medicine. A patient’s survival for just one more year or one more month or even one more day, would bring endless joy to everyone.

Who Do You Trust?

Do you trust all doctors?
Do you trust all doctors? | Source

Smoking Can Cause Bladder Cancer

Avoid smoking as it causes many diseases.
Avoid smoking as it causes many diseases. | Source

A Victim September 2010

My husband may be a victim of the problem with actos, as he has bladder cancer and is on the drug Actos.He telephoned the report to the FDA, and is awaiting the form to complete for them. The dosage of Actos is 15 milligrams daily.. In February 2009, a urologist diagnosed the cancer and he underwent surgery for Stage 1 bladder cancer.At this time, he had been on Actos for four years, and there was nothing on the Actos blurb about bladder cancer or male rats with tumors. His cancer is on the wall of the bladder with no incidence elsewhere. He underwent chemotherapy called BCG and has follow up checks every three months, then six months, and then yearly.

More history and indecision about action

In October 2009, a few spots showed up, and they were removed, and he underwent more chemotherapy It is now September 2010, and he is in remission and is on the three-month checkup period. Some physicians indicate that bladder cancer grows slowly and that older men who are victims usually live a normal life span.This may be speculation, but we hope it is true.I reordered the drug printout and found no notation of bladder cancer in male rats, so we were clueless about this fact. I did find a webpage entry on the Internet from 2009 which mentioned it, so this information eluded us..

Bladder cancer is not a disease that is prevalent in my husband's family, Heart disease runs in my side of the family, so this was a new experience. We thought it would never happen to us. The experience was very frightening. First, the surgery took place, and everybody sat in the waiting room hoping for the best. We have already been through open-heart surgery with my husband, and we survived that ordeal. However, the cancer word is a mystery word. The prognosis is unknown.

So what do we do now? Do we become angry with the drug company about inadequaate information about Actos or the FDA or the prescribing physician? Or do we just accept it as being a part of life?. Do we file a lawsuit? The answers are unknown. We may never know if the drug caused the bladder cancer. On September 25, 2010, he started a new drug Metformin, following a telephone call to his physician..

Innocent victims of drugs

Probably many people have found themselves in similar situations to ours, and deserve compassion for their ordeals. It may be another drug that caused their problems. I also feel sorry for the people who pay no attention to the news and barely make it on their own. Who tells them about situations like this? How do they handle their medications and side effects and all the compound problems that may occur?. It makes a person feel grateful to have the skills to handle situations.


What have we learned from this experience that might help others?. One, is to always read the drug brochure thoroughly and question anything that does not seem quite right. Also, we must pay attention to any changes in our bodies after beginning a new medication. We have a great pharmacist whom we call about any interactions, even with herbs, so being in touch with the important. We know now to check with the FDA website if questions arise, and to be inquisitive with physicians. If a brochure stated that bladder tumors were found in preclinical trials of a drug, we would not take the medicine. The most important lesson is that no matter what circumstances or crises arise, we need to take charge of our own health, because no one else will do it for us. We need to stay informed by reading and asking questions and insisting on answers without relying solely on physicians' advice or information about medication.. We need to be ready to challenge facts and think outside the box, to ensure better and safer lives for ourselves and others.

Actos Lawsuit Information

Video on Bladder Cancer Causes


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    • brakel2 profile image

      Audrey Selig 2 years ago from Oklahoma City, Oklahoma

      Hi Torrilyn Thanks for your first comment about the settlement of the lawsuit. The whole situation is sad about physicians pushing drugs and TV commercials pushing drugs. I don't know what is happening in the world of medication any more. My husband was enticed into taking this drug, and it does not seem fair. At least he is in remission. Thanks for stopping by. I sure do appreciate it. Blessings, Audrey

    • torrilynn profile image

      torrilynn 2 years ago

      I'm sorry for what happened to your husband. It is ridiculous how the drug companies come out with these new drugs and then a few days later you see a commercial on t.v. saying how you can sue if you used the drug. it's ridiculous the extent certain people would go to in order to make money. thanks for the hub. Best of wishes.

    • MissJamieD profile image

      MissJamieD 5 years ago from Minnes-O-ta

      Aaww, thanks Brakel, I appreciate that and I do feel for you and your husband. Although I have to give a big Amen for him being in remission. Best of luck to you both:)

    • brakel2 profile image

      Audrey Selig 5 years ago from Oklahoma City, Oklahoma

      Thank you for reading my hub Your comments encourage us. Luckily, the cancer has been in remission for some time, and we feel fortunate. He has a great doctor, and that means a lot. The FDA needs overhauling. His primary care physician talked him into trying this drug, which was not the preferred drug for diabetes. I hope drug companies and physicians see the light Anyway, we sure love your compassion.

    • MissJamieD profile image

      MissJamieD 5 years ago from Minnes-O-ta

      Wow this is very sad. I'm sorry to hear about your husband. I wish him a full recovery. It's so sickening how little testing they do on drugs and then leave humans to be the "gineau pigs". We are supposed to believe what our doctors tell us but so often they are working for the pharmaceutical companies and are wishy washy. Very sad. Great hub, very informative!

    • brakel2 profile image

      Audrey Selig 5 years ago from Oklahoma City, Oklahoma

      Hi HisMiss - I am very sorry about your husband's illness. Yes, we went through all that. He is still in remission, so I pray that your husband will go into remission also. Dick goes every six months now, and in the beginning it was three months. I hope he did not take Actos, but if so, good luck to you with that issue. Thanks for visiting this website, and come back again. Your comments and good luck mean a lot to us.

    • profile image

      HisMiss 5 years ago

      My husband's story is very close to yours. We go to the Urologist this week for his first 3 month check after surgery and chemo. We pray this report, and every other one he has to face, will be negative. Good luck and good health to all of you.

    • brakel2 profile image

      Audrey Selig 6 years ago from Oklahoma City, Oklahoma

      Thanks Carolinemoon for the nice comment about my hub and husband. He is still in remission but has filed a lawsuit as many are doing, due to the failure to warn patients of the possibility of bladder cancer. It has certainly been a learning experience. Thank you also for following me. I will definitely look for your hubs. Happy writing.

    • carolinemoon profile image

      carolinemoon 6 years ago

      Great to know he is in remission. Great hub.

    • gullfraz786 profile image

      gullfraz786 7 years ago

      nice hub

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Hi Bayoulady - Thanks for reading my hub. You are so good to read so many, and I appreciate the comments about my husband and the alert and links. You sure pay attention when you read a hub. Great! Good luck with your writing, and have a good evening.

    • bayoulady profile image

      bayoulady 7 years ago from Northern Louisiana,USA

      Sorry I'm late getting to this hub.Thanks for stopping by my new one as that reminded me to see if you had a new! I am so sorry for what your husband is enduring. I am glad you wrote this alert, and provided such great links as well.

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Amberrisme -thank you so much for your prayers and compassion and for reading the hub. They should have an informative button. Hold that thought! Good luck in your endeavors and all your writing. I will look for your hubs.

    • amberrisme profile image

      amberrisme 7 years ago

      They don't have an "informative" button or I would have clicked that. Praying for your family and h.r. borcich's as well.

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Hi and thank you for the information. He is in Stage 1, and I am sorry about your cancer. We wish you well. We will go to that webite. I hope that you will have a good result with your disease. I want to read your hubs and follow you. You are a very compassionate person. Good luck with your writing.

    • h.a.borcich profile image

      h.a.borcich 7 years ago

      Hi Brakel2,

      Sorry to hear your husband is dealing with bladder cancer after everything else. I too am fighting bladder cancer although mine was not caught early.

      Have you been to the American Bladder Cancer Society website? It is a very extensive site on bladder cancer, complete with survivors, medical info, access to very knowledgable researchers, and tons of support.

      Your husbands diagnosis sounds like a T1 and noninvasive which is one of the most treatable bladder cancers. He will need cystoscopes for life but the odds a low grade bladder cancer will progress are low.

      Thanks for the informative hub, and be well! Holly

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Hi bayoulady - Thanks so much for your comments on my hub. I wrote it as a service to others, but don't know how many will see it. Maybe I need to change the title to add that it is a personal story of a patient. I enjoy reading your hubs.

    • bayoulady profile image

      bayoulady 7 years ago from Northern Louisiana,USA

      brakel, I hope this hub gets tons of traffic, because this is an important service article. Thanks for all the information, phone numbers, and advice you gave. I hope your husband is doing well.~~Jackie~~

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Thank you John000 for reading my article and for your kind comments about the remission. It is so nice that people care. I read one of your hubs and enjoy your writing. Keep up the good work.

    • john000 profile image

      John R Wilsdon 7 years ago from Superior, Arizona

      It is so good to read that you took charge of your own health and that of your husband. So glad he is in remission. Nice article.

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Thank you doctor for reading my hub and noting my concerns and being willing to spread the word. I am now following you and will enjoy reading your hubs.

    • D.Virtual.Doctor profile image

      Funom Theophilus Makama 7 years ago from Europe

      hmmm! great awareness...

      It has been noted and the word would be duly shared.

    • brakel2 profile image

      Audrey Selig 7 years ago from Oklahoma City, Oklahoma

      Thank you Lisa. You give me encouragement. I appreciate all your comments in my hubs. Keep up the good work. I love your writing.

    • Lisa HW profile image

      Lisa HW 7 years ago from Massachusetts

      It sounds promising that he's in remission now. (My uncle had bladder cancer and was treated for it. My mother-in-law was treated for color cancer in her seventies. Both people went through the whole follow-up thing for the five years after treatment. Both died years later of unrelated conditions.)