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Tardive Diskenesia Caused by Anti Psychotics and Other Drugs

Updated on February 27, 2018
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Lori Colbo is a certified mental health peer counselor. She shares information found in research and personal experience.

Source

What is Tardive Dyskinesia?

Tardive Dyskinesia (TD) is a movement disorder most commonly caused by the use of neuroleptic drugs. TD usually manifests in involuntary, repetitive facial movements, mouth movements, and sometimes body movements. Here are the symptoms of TD:

  • lip smacking
  • chewing
  • sucking
  • facial movements
  • tongue protrusion
  • grimacing
  • extremity movements
  • rapid eye blinking or twitching

TD affects about 500,000 people in the United States.1 Women and people over the age of 65 are more sensitive to TD when on the offending medications. In older people the metabolism slows down and is not able to process the medication as effectively.2 Approximately 15-30% of persons who receive long-term treatment with neuroleptics are afflicted with TD.3

What Causes Tardive Dyskinisia?

TD usually occurs after longer-term use of antipsychotic and other medications as well (see list below). Often patients who take large doses of these medications are more at risk, especially with prolonged use. Tardive Dyskinesia has no cure and in many cases is a permanent condition. There are a few treatments available, but research shows they have a low success rate. In many cases, the best way to treat TD is to prevent it by monitoring the patient regularly, and keeping doses at a minimum. It is advised that at the first signs of TD, the medication should be discontinued (with doctor recommendation). With many of the neuroleptic medications, such as the antipshychotics, the discontinuance of the drug often does not guarantee that the TD will stop. In fact, in many cases the very offending medication may mask the condition, or only allow it to manifest mildly. TD may actually get worse or begin after going off antipsychotic medications. It's really a double edged sword.

Long-term use of Dopamine Antagonists can cause tardive dyskinesia. According to TD Center website, "These medications operate by blocking receptors in the dopamine pathway of the brain, which controls voluntary muscles and certain emotional response mechanisms (known as the nigrostriatal pathway)."

Source

Medications That Can Cause TD

Here is a list of medications that can cause Tardive Dyskinesia (this is not an exhaustive list):

Neuroleptic drugs

  • Abilify (Aripiprazole)
  • Clozaril (Clozapine) (may also treat the condition)
  • Geodon (Ziprasidone)
  • Haldol (Haloperidol)
  • Loxitane / Loxapac (Loxapine)
  • Mellaril (Thioridazine)
  • Navane (Thiothixine)
  • Orap (Pimozide)
  • Piportil (Pipotiazine)
  • Prolixin / Modecate (Fluphenazine)
  • Risperdal (Risperidone)
  • Serentil (Mesoridazine)
  • Seroquel (Quetiapine)
  • Stelazine (Trifluoperazine)
  • Thorazine (Chlorpromazine)
  • Trilafon (Perphenazine)
  • Zyprexa (Olanzapine)

Non-neuroleptic Drugs

  • Asendin (Amoxapine)
  • Cocaine and other street drugs
  • Elavil (Amitriptyline)
  • Lithium
  • Nardil (Phenelzine)
  • Prozac (Fluoxetine)
  • Sinequan (Doxepine)
  • Tofranil (Imipramine)
  • Zoloft (Sertraline)
  • Reglan (metoclopramide)
  • Compazine (prochlorperazine)
  • Phenergan (promethazine)

Treatment Options

As I said, there are few effective treatments of TD. According to brainandspinalcord.org, some doctors and practitioners suggest Vitamin E, however there is no scientific proof yet that it is effective.

There are a few drugs that may lessen the severity of TD. Tetrabenzine is one that reduces dopamine levels and sometimes has been known to calm symptoms down. Other medications sometimes helpful are:

  • Miraplex (an anti-parkinson's medication).
  • Benzodiazipines (tranquilizers) have had minimal success in reducing the symptoms
  • Propanolol
  • Clozapine
  • Botulinum toxin

There are side effects to some these medications, so caution is needed. Clozapine (not clonidine or clonazapam) has some serious side effects and requires a lot of monitoring and regular blood work.

In the last year, the FDA has approved two new drugs for treatment of TD.4 Here is a list:

Ingrezza (valbenazine). A clinical trial of 234 people suffering from TD, after six weeks there was a significant improvement.

Austedo (deutetrabenazine). Originally FDA approved for chorea associated with Huntington's Disease, It was shortly found to help with TD.

Ken Duckworth MD, President of NAMI, offers hope with these two new medications. "I have felt a bit helpless in the past when I see people who experience TD. We didn’t have any treatment options approved by the FDA. But now we have two new tools and I look forward to learning more about these medications from my patients’ experiences and scientific literature."

Source

What Should You Do If You Take a Medication That Causes TD?

If you take a drug that is known to cause TD, but you do not at this time have symptoms and it worries you, talk to your doctor right away, ask questions and let him know your concerns. He will be able to assess TD symptoms with something called the Abnormal Involuntary Movement Scale (AIMS) scale. This assessment should be done about every six months

Sources

1 Brainandspinalcord.org Tardive Dyskisia Treatment Options. http://www.brainandspinalcord.org/tardive-dyskinesia-treatment-options/

2 NAMI. Tardive Dyskinisia. https://www.nami.org/Learn-More/Mental-Health-Conditions/Related-Conditions/Tardive-Dyskinesia

3 Drugs.com Teva Announces FDA Approval of Austedo (deutetrabenazine) Tablets for the Treatment of Tardive Dyskinesia in Adults. Teva Pharmaceutical Industries Ltd. https://www.drugs.com/newdrugs/teva-announces-fda-approval-austedo-deutetrabenazine-tardive-dyskinesia-adults-4589.html

4 NAMI. FDA Approves Medications For Tardive Dyskinesia, Ken Duckworth. https://www.nami.org/Blogs/NAMI-Blog/September-2017/FDA-Approves-Medications-for-Tardive-Dyskinesia

© 2011 Lori Colbo

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    • lambservant profile image
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      Lori Colbo 5 years ago from Pacific Northwest

      Hey schoolgirl, glad to hear you are doing well. Been a little stress in my life the last several days, but I glorify the name of the Lord for he is the same yesterday, today, and forever, amen.

    • schoolgirlforreal profile image

      schoolgirlforreal 5 years ago

      Beautiful work, lambservant, how are you?

      I'm doing very well, and greatful!

    • Huntgoddess profile image

      Huntgoddess 5 years ago from Midwest U.S.A.

      Thanks so much for this. I love Dr. Breggin, also.

    • schoolgirlforreal profile image

      schoolgirlforreal 5 years ago

      Yes

      I give him credit for my recovery as well. Amen!!

    • lambservant profile image
      Author

      Lori Colbo 5 years ago from Pacific Northwest

      Blondey, Yes, I discovered that Dr. Breggin was no a hubber. I think I may have seen him on Youtube a long time ago but not sure. Regardless, Jesus is our Great Physician, and I give Him credit for my recovery. Do I hear and amen?

    • blondey profile image

      Blondey Hubpages 5 years ago

      Thank you dear.

      It's truly faith in God that is sorely needed for the "hopeless" Dr. Breggin speaks of that in his book (not a hub, a book by him) He's called the "conscience" of psychiatry, a most remarkable man. What a wonderful person to have in this mixed up world of psychiatry!!

    • lambservant profile image
      Author

      Lori Colbo 5 years ago from Pacific Northwest

      Schoolgirl, it is sad you were on medication for 20 years that made you feel that way. Certainly the doctors should have realized at some point along the way when more medications were being developed that you needed something else.

      I have also read a lot about the use of antidepressants not being good for those with bipolar. Don't know if that's been an issue for you. There is so much controversy over whether meds are bad or good, if the drug companies and medical professionals, who are always in bed together (as one hubber told me) are just trying to make money at our expense. All I Know is that I am currently doing well on medication combination as far as mental and emotional stability goes. I may have a very slight TD coming on so I'm watching it. I will read the hub you recommended and get back to you. Thanks for your comments.

      Blondey, It is disturbing. I hate watching it. It is a sad turn of events for such a sweet little girl. I'm glad it's more of the exception than the rule. Blessings.

    • blondey profile image

      Blondey Hubpages 5 years ago

      Just watched the video of the little girl.

      Can't even comment right now.

      Have a blessed night!

      +

    • schoolgirlforreal profile image

      schoolgirlforreal 5 years ago

      I go to a medication info group weekly run by counselors, (but I always end up contributing a lot) and it pisses me off! I'm stopping going.

      Medication makes me mad. I was on lithium for 20yrs; it made me angry and sucidal. I'm not anymore.

      Please God--

      Read "Your Drug May Be Your problem" by Peter Breggin, just a suggestion!

      :-)

      xo

    • gsidley profile image

      Dr. Gary L. Sidley 5 years ago from Lancashire, England

      An informative and well-written hub that highlights the risk of serious side-effects associated with anti-psychotic medication. Sadly, these risks are typically understated by psychiatrists.

      I've recently written a hub that includes reference to tardive dyskinesia (along with descriptions of historical psychiatric treatments that did far more harm than good). Feel free to drop by.

    • GarnetBird profile image

      Gloria Siess 6 years ago from Wrightwood, California

      GREAT Hub/I was on haldol over 20 yrs ago and had to stop taking it due to the dental problems it caused, plus the numbness.I am on Neurotin for nerve and spinal pain and have found out it can cause blindness. So many medications have horrific side affects--would love your comments on my Hub on Zetia, which nearly killed me. God bless You, Garnet (Gloria)

    • blondey profile image

      Blondey Hubpages 6 years ago

      Trilaphon is a very old medication I took about 15 years ago, it's also called perphanazine I think. Anyways it has the same effects of seroquel in so far as usage.

    • lambservant profile image
      Author

      Lori Colbo 6 years ago from Pacific Northwest

      Schoolgirl, I have never heard of trilaphon, what is that? I'm glad you have a good psychiatrist. Thanks for stopping by sister. God bless!

    • schoolgirlforreal profile image

      schoolgirlforreal 6 years ago

      Hi lambservant,

      I am glad you made this hub. I'm on abilify now for like a week....I grind my teeth but I know that's not a side effect. As for what you mentioned I don't think I have it, but it's good to be aware.

      I used to be on trilaphon which said caused it so I got off. I'm on seroquel too. But I"m on a lower dose now. My psychiatrist watches for symptoms, and I'm glad yours does too.

      This is a very useful hub!

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