ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

When to believe, when not to? When is enough, when it's not? - Dosing guide.

Updated on May 10, 2012

Speaking in name of those...

... Living in these days, make us to accept some things that weren't usually "normal" just a couple of years ago. Living in modern world, living an modern - open minded life, brought us some new things that we need to consider as "normal". An perfect example of EX-taboo subject to talk about is "drug addiction" , in a meaning of heroin addiction - AND, sadly, newly produced taboo made by stigmatic behavior of society is substitution treatment of heroin or opiate addicts....

Questioning = Gambling ?

Have you ever been in situation that you HAVE TO question yourself, twice, before you believe in a words of an ex heroin addict, that is currently on substitution treatment ? Have you ever caught in situation when you need to think about whether or not, someone close, is just abusing the trust of the specialized doctor for prescribing an opiate substitute ? Well, all of you are on RIGHT PLACE. We are here to discuss of all these topics that, I bet, are bothering you so much - in some cases over AN DECADE... Yes, some of us, can live in a DECADE of not-reliable, and questioning kind of relation with son,cousin,wife,or husband when it is about something important, and crucial, like: "Is he/she lying me now? Does he/she really need a higher dose,or all he/she wants is to try to get high?" or " Is the dose that my ... is receiving enough for him? Is it too high/low ... ? - The questioning, itself, brings gambling with someones life and getting back him on "old track" - on heroin.

Dosage of "substitute" that's used in opiate based substitution treatment is crucial and INDIVIDUAL.
Dosage of "substitute" that's used in opiate based substitution treatment is crucial and INDIVIDUAL.


Do you think that someone, person that's on Methadone, is abusing it's dosage to be "high" ? Do you think that the dosage is too high ? Well, we will discuss here little bit about when "enough" is actually "enough".

Usually, those "Methadone Guides" are telling us that dosage between 60-120mg is usually enough for stabilizing the patients condition.The dosage under 60mg is considered insufficient because of lacking in "blockade" effect of heroin's euphoria.Consider this sentence like this: dosages upper than 60mg are considered enough, because there is enough methadone to "cover" all opioid receptors with it's molecules - so the heroin which has little bit less affinity to the mu receptors, and kappa - will not leave ANY effect if it's administrated on any way. So imagine your receptors as an some "wholes" ... And methadone molecules as an "big rocks"... Bigger rocks have a greater speed of rolling to the "whole",and th

ey will came first to the "whole" taking it's full size and not letting anything to pass in to the "whole". Now you have to understand that those "big rocks" also effect on those "wholes", penetrating them - stimulating - to "give" more dopamine. So the "big rocks" were the molecules of methadone,small ones were the heroin molecules,morphine - and the "wholes" were mu-opioid receptors.I think, I've really explained you now how the things are going. Now, the thing is - how many "big rocks" do the person need and when it's enough ?

  • It is obvious from the text that 60mg of methadone hydrochloride is enough to reach the point where, generally, people get the "block" effect of the methadone. NOTE : DO NOT MIX METHADONE,FROM TEXT ABOVE AND THE WAY OF FUNCTIONING, WITH OPIATE ANTAGONISTS.METHADONE IS PURE SYNTHETIC OPIATE AGONIST. But, as the maintenance therapies with opiate substitutes are specified, THE INDIVIDUALIZATION IS NEEDED AND CRUCIAL - THERAPY AND THE THERAPEUTIC EFFECT IS DIFFERENT FROM PERSON TO PERSON.

Because of individualization, and different types of reactions to methadone, specialized personnel - that should be approved for prescribing methadone - is adjusting the dosage by several things that are different from person to person.The obvious example is that first dose, that patients get...Someone will be "covered" ,and satisfied, with 20mg ; while the other one wouldn't be able to "handle" his withdrawal symptoms with 40mg even tho he/she is younger than him/her. The factors that affect to the methadone's effect mechanism could be: metabolism,liver state,developing/delivering liver enzymes...and many other factors could be crucial when it is about "the right dosage" for different person. Usually, the dosage between 75-150mg are enough for those who are more than six months in M.M.T (Methadone Maintenance Treatment), and tried to adjust the dosage AND them-self's to lower ones but from some reason - they found them difficult to coup with.

Don't kill the hope. Hope for better tomorrow and maybe some day"drug free" is something that keeps patients on maintenance pushing forward.
Don't kill the hope. Hope for better tomorrow and maybe some day"drug free" is something that keeps patients on maintenance pushing forward.

Pressure on the patient, believe or not ?

Pressure on the patient in a meaning of questioning him:"Is the rising of dosage really necessary?" brings nothing but negative effect.The person will feel himself like...Like he did nothing, he gained nothing good while treatment - he gained not a bit of trust back from his closest persons, whether that persons are his parents,his grand-parents,close friends,cow-workers - generally, persons close to him. There is enough stigma in society, in general, attached to the opiate maintenance way of treating, and adding some more pressure and misunderstood facts about opiate that he/her is maintaining on ; will done no good to him.

Understanding the fact that everyone is reacting different on opiate maintaining is really crucial. The worst thing you can do is to NOT BELIEVE to the patient, on opiate maintenance treatment, about his needs for rising and additional (maybe) medications. You, or close friends (not to mention his supervised doctor) will notice if the dose is too high, but generally - patients just want to feel "all right" - trough the all day.They want, generally, to avoid withdrawal effects during day. Imagine them, on work, having withdrawal symptoms in front of their colleagues (not to mention boss or the situation on some meeting where concentration and spiritual "feeling good/normal" are CRUCIAL indeed)

What is maybe even worse than "not believing" to the stable patient( patient that is regular on his appointments and negative on drug tests) , is blackmailing person with "head under the roof" if he/she rises his/her dose. Blackmail, or whatever, in a sense of connecting the dosage with life existence (residential question) - is something that can be a trigger for getting back to heroin and potential death. Do we want our close person to see death? In coma? Generally, in near death experience ?! Well, think about it. I think that non of us want any of that to the closest persons.


List of side effects that CAN (not necessarily) occur during treatment.
List of side effects that CAN (not necessarily) occur during treatment.
Cast your vote for THIS HUB


    0 of 8192 characters used
    Post Comment
    • lafamillia profile imageAUTHOR


      7 years ago from Soutcentral Europe


      -The best way to quit Tramadol, and to kick the WHOLE addiction to it is the "Serbian Revers Pyramid" method.

      If you follow NEXT STEPS, precisely, you'll get of...

      It is about ten day of detoxing yourself with the medication that you're actually already using...:

      The dosages, in following therapy, should be taken exactly as written AT : 8am ; 2pm ; 8pm NOTICE: Additional doses of specific medications, like "midozolam" ; should be considered and/or taken exactly as prescribed !!



      = DAY ONE =

      Tramadol {GENERIC} 50mg 4+4+4 , Diazepam[5mg] 2+1+2 ; Rivotril{clonazepin]2mg 0+1+1 , Flormidal {midozolam} 0+0+2

      = DAY TWO =

      Tramadol {GENERIC} 50mg 4+4+4 , Diazepam[5mg] 2+1+2 ; Rivotril{clonazepin]2mg 0+1+1 , Flormidal {midozolam} 0+0+2

      = DAY THREE =

      Tramadol {GENERIC} 50mg 4+3+4 , Diazepam[5mg] 1+1+2 ; Rivotril{clonazepin]2mg 0+1+1 , Flormidal {midozolam} 0+0+2

      = DAY FOUR =

      Tramadol {GENERIC} 50mg 3+4+3 , Diazepam[5mg] 2+1+2 ; Rivotril{clonazepin]2mg 0+1+1 , Flormidal {midozolam} 0+0+2

      = DAY FIVE =

      Tramadol {GENERIC} 50mg 3+3+3 , Diazepam[5mg] 1+1+2 ; Rivotril{clonazepin]2mg 0+1+1 , Flormidal {midozolam} 0+0+2

      = DAY SIX =

      Tramadol {GENERIC} 50mg 3+2+3 , Diazepam[5mg] 0+1+1 ; Rivotril{clonazepin]2mg 0+1/2+1 , Flormidal {midozolam} 0+0+2

      = DAY SEVEN =

      Tramadol {GENERIC} 50mg 2+2+3 , Diazepam[5mg] 0+1+1 ; Rivotril{clonazepin]2mg 0+1/2+1 , Flormidal {midozolam} 0+0+2

      = DAY EIGHT =

      Tramadol {GENERIC} 50mg 1+1+2 , Diazepam[5mg] 0+1+1 ; Rivotril{clonazepin]2mg 0+1/2+1 , Flormidal {midozolam} 0+0+2

      = DAY NINE =

      Tramadol {GENERIC} 50mg 0+0+1 , Diazepam[5mg] 0+1+1 ; Rivotril{clonazepin]2mg 0+1/2+1 , Flormidal {midozolam} 0+0+2

      = DAY TEN =

      Tramadol {GENERIC} 50mg 0+0+0 , Diazepam[5mg] 0+1+1 ; Rivotril{clonazepin]2mg 0+0+1/2 , Flormidal {midozolam} 0+0+2


      MANY MANY SWEETENERS { candies, chocolate...etc } and MANY MANY salted food . These two, will replace intra-medical way of infusion bags from 0.5l x 2 of NaHCL , and 0.5l of ..hmm...i can't remeber now the name ... it's "basic" sugar infusion ...

    • jesusmyjoy profile image

      Betty Bolden 

      8 years ago from Bucyrus Ohio

      I know addiction..I have fibromyalgai and joint problems and thinning of the bones..i stay in constant pain..I have been addicted to all kinds of perscribed pain pills. please follow my blog at the link and learn about me..God bless you will enjoy my posts..

    • profile image


      8 years ago

      I am an huge addict from Tramadol,in combination with diazepam... I really wanna quit my adiction in order to fix my life and get with my wife and child back good again.can someone, you help me? Thank you a lot.


    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at:

    Show Details
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the or domains, for performance and efficiency reasons. (Privacy Policy)
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
    ClickscoThis is a data management platform studying reader behavior (Privacy Policy)