ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Chronic Relapsing Pancreatic Disease Of The Tropic Or Pancreatic Diabetes As The Main Cause Of Mellituria

Updated on February 18, 2014

Mellituria Affects More of Childre

The disease affects children and young adults in the age groups of 15 to 35 years. Both sexes are equally affected. In one third cases, previous history of painful episodes of recurrent pancreatitis may be available.
The disease affects children and young adults in the age groups of 15 to 35 years. Both sexes are equally affected. In one third cases, previous history of painful episodes of recurrent pancreatitis may be available. | Source

Geographical Distribution

Chronic relapsing pancreatitis is confined almost exclusively to the tropics, mainly in Africa, India, Indonesia and Malaysia. In India for instance, most of the cases have been reported from the midland and the hilly tracts of the southern districts of Kerala and Tamil Nadu. Smaller numbers have been reported from many other parts, especially Karnataka and Orissa.

Etiology And Pathogenesis: Almost all cases belong to the poor socio-economic groups which consume cassava as their staple food, and in whom protein caloric malnutrition, helminothiasis, and frequent viral infections are common. The established causes of pancreatitis such as alcoholism, gall bladder disease, hyperparathyroidism and hyperlipidemias are absent in these cases. The disease may affecte several members in the same household.

Pathology: The pancreas shows intra and inter acinar fibrosis with moderate round cell infiltration. The acini and islets undergo total atrophy and replacement by fat. The ducts are dilated and numerous intraductal calculi made up of calcium in the itnerstices. The beta cells of the islets are reduced and this accounts for the diabetic state. The liver shows mainly glycogen infiltration and rarely fatty change and cirrhosis. In long-standing cases, the kidneys, retina and peripheral nerves show lesions similar to those seen in maturity- onset diabetes. The parotid glands are prominent and they show ductal dialatation and round cell infiltration.

Epigastric Pain Is A Major Sign

The pain is of a colicky or gnawing nature felt over the epigastrium. This differs from that of peptic ulcers in having no relation to food and not being relieved by antacids. Pressure over the episgatrium gives prompt relief. The physical appearance
The pain is of a colicky or gnawing nature felt over the epigastrium. This differs from that of peptic ulcers in having no relation to food and not being relieved by antacids. Pressure over the episgatrium gives prompt relief. The physical appearance | Source

Clinical Presentations

The disease affects children and young adults in the age groups of 15 to 35 years. Both sexes are equally affected. In one third cases, previous history of painful episodes of recurrent pancreatitis may be available. The pain is of a colicky or gnawing nature felt over the epigastrium. This differs from that of peptic ulcers in having no relation to food and not being relieved by antacids. Pressure over the episgatrium gives prompt relief. The physical appearance of these subjects is diagnostic. They show extreme emaciation, distention of the upper abdomen, cyanotic hue of the lips, and bilateral painless parotid enlargement. Growth and development are retarded. Women develop secondary amenorrhea. Urinary bladder is grossly distended and atonic. The patients generally seek treatment for diabetes or its complications.

The diabetic state is often severe, requiring high doses of soluble insulin for control. In the majority of cases, the fasting and postprandal blood glucose levels are high. With the passage of time, the diabetes becomes brittle in many cases.

Laboratory features: Fasting and postpandial blood glucose levels are very high. Pancreatic enzymes are lowered. Plasma immunoreactive insulin is reduced.

Comments

    0 of 8192 characters used
    Post Comment

    No comments yet.

    working

    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://hubpages.com/privacy-policy#gdpr

    Show Details
    Necessary
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
    Features
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Marketing
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Statistics
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)