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Gastric Ulcer or Peptic Ulcer

Updated on December 2, 2013

Peptic Ulcer- An ulcer in the lower esophagus, stomach or duodenum can be commonly called peptic ulcers. Duodenal ulcers are not malignant, but about 5% gastric ulcers are cancerous.

The exact reason for the production of ulcer is unknown, but the various factors that can lead to ulcer:

  • Gastric hypersecretion: can be one among the reasons for the causation of peptic ulceration. Severe intractable peptic ulceration is found in patients having very high acid secretion. Reduction in gastric acid secretion by drugs helps in ulcer healing.
  • Acid Pepsin: Peptic ulcer is produced when the aggressive effects of gastric or duodenal mucosal resistance; as a result acid and pepsin of gastric juice digest the mucosa of stomach and duodenum.
  • Heredity: Ulcer patients often have a family history of the disease. Incidence of gastric ulcer in relatives is 2 times that of incidence in common population.
  • Mucosal Resistance: Gastric mucus, secreted by gastric mucus cells, coats the mucosal surface of the stomach. This mucosal barrier is broken by various agents like, alcohol, AIDS, acid reflux, aspirin, weak organic acids and decreased mucosal blood flow.

Difference between Gastric and Duodenal ulcer

Gastric Ulcer
Duodenal Ulcer
Usually single
May be multiple
After meals
In between meals
Gastric acid
Low or normal
Not relived by food
Relived by food
Commonly seen
In lower socioeconomic class
Equal prevalence
Chronic forms
May be benign or malignant
Usually benign

How to know that a gastric ulcer is malignant

  • Symptoms; Anorexia and weight loss, dysphagia, epigastric pain not related to food.
  • Signs

Epigastric mass

Metastasis indicated by; supra clavicular nodes, large irregular hepatomegaly, ascites, tumor of the ovary, deep vein thrombosis of leg.

  • Radiological showing: filling defect and failure of peristalsis in a site other than middle 2/3 of lesser curvature.

Very large ulcer anywhere in the stomach. Leather bottle stomach.

  • Gastroscopy and gastric cytology showing malignancy.
  • Gastric endoscopic US shows degree and extent of infiltration.


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    • dinkan53 profile image

      dinkan53 5 years ago from India

      @beingwell Maintaining a diet that promotes an alkaline pH within the body is important for proper health. Thanks for the share and comment.

    • beingwell profile image

      beingwell 5 years ago from Bangkok

      Shared this one.

      I'm acidic this really helps.

    • dinkan53 profile image

      dinkan53 5 years ago from India

      @remaniki Thanks for your valuble comment and special thanks for sharing my hub.

    • remaniki profile image

      Rema T V 5 years ago from Chennai, India

      Hi dinkan53,

      As a person who is very much interested in health articles such as this one,I think everyone must get to read it. Great hub!Thanks for the knowledge. Socially shared.



    • dinkan53 profile image

      dinkan53 5 years ago from India

      @BlossomSB Thanks as you found my hub as an useful one. What about your gastroscopy, hope every thing is fine and wish you good health.

    • BlossomSB profile image

      Bronwen Scott-Branagan 5 years ago from Victoria, Australia

      Thank you for an interesting hub. I'm off today for a gastroscopy, so it is timely! Voted up and interesting.

    • Injured lamb profile image

      Injured lamb 6 years ago

      Appreciate much for this informative hub that you have put your effort on the I have a clear picture of what a gastric ulcer is...shhhh...I have a gastric problem that always seem love to kill me...