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Importance of Progesterone in women health

Updated on November 11, 2010

Progesterone which sometime called the "hormone of pregnancy, is a major naturally occurring hormone. It is produced in women ovaries during ovulate and it’s main function to supporting pregenency.But it supports overall reproductive system relating to the development of the fetus (developing human).

Actually it seems to that only progesterone has all human development responsibility when discussing its role in human body and specially women reproductive system. Here some main functions are-

Primary Effects

  • Progesterone converts the endometrium (three layered membrane lining the uterus) to its relating stage to prepare the uterus for entrenching.
  • Progesterone affects the vaginal epithelium (a membranous cellular tissue that covers a free surface or lines a tube or cavity to enclose and protect the other parts of the body) and cervical secretion, making it thick and impermeable to sperm.
  • If pregnancy does not occur, progesterone levels will decrease, thus leading in the human, to menstruation. Normal menstrual bleeding is infecting progesterone-withdrawal bleeding.
  • During implantation and development, progesterone helps to decrease the maternal resistant response to allow for the acceptance of the pregnancy.
  • Progesterone decreases contractility of the uterine smooth muscle.
  • Progesterone prevents lactation (breastfeeding) during pregnancy. After pregnancy progesterone levels fall and helps to triggers for milk production.
  • Drop of progesterone levels is one step that accelerates the start of labor.
  • Progesterone also has potential to improve memory and perceptive ability.
  • Progesterone affects regulation of apoptotic genetic factor.
  • It acts as an anti-inflammatory agent and corrects the resistant response.
  • It regulates blood thickening and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy.
  • It may affect gum health, increasing risk of gum inflammation and tooth fall-off.
  • Helps to prevent endometrial cancer (uterine lining) by regulating the effects of estrogen
  • Progesterone supports the normal development of neurons in the brain, and that it has a protective effect on damaged brain tissue.
  • Progesterone is starting to use in the treatment of the skin condition.

Specific Use

  • Progesterone is used to control ovulatory bleeding. It is also used to prepare uterine lining in infertility therapy and to support early pregnancy. Women who suffer immature pregnancy loss caused by insufficient progesterone production can receive progesterone to get that support.
  • Progesterone helps prevent preterm birth in women with a history of preterm birth.
  • Progesterone is used in hormone therapy for transsexual women and women with intersex conditions.
  • Progesterone can correct breast shape when both estrogen and progesterone are combined even after years of insufficient hormonal treatment.
  • Progesterone also has a role in skin elasticity and bone strength.
  • In inhalation, in nerve tissue and in female sexuality, and the presence of progesterone in certain muscle and fat tissue.

Side Effects

Whereas balance is most important in both natural and artificial measures, when ever something exceeds from certain points inadequacy occurs. So progesterone also has number of side effects-

  • It can cause increased fluid retention which can result in epilepsy, migraine, asthma, cardiac or renal dysfunction (kidney failure).
  • Blood clots may develop resulting strokes and heart attacks which may lead to death or long-term disability.
  • Breast cancer can also develop as a result of progesterone therapy.
  • Current research shows that progesterone plays an important role in insulin releasing and pancreatic (gland produce hormones including insulin) function, and may affect the exposure to diabetes. It has been studied that women with high levels of progesterone during pregnancy are high at risks to develop glucose irregularities.

Common effects

Cramps, abdominal pain, skeletal pain, perineal pain, headache, arthralgia, constipation, , diarrhea, nausea, vomiting, breast enlargement, joint pain, flatulence, hot flushes, decreased libido, dehydration, increased appetite, drowsiness, excessive urination at night. Depression , mood swings, emotional uncertainty, aggression, abnormal crying, insomnia, poor memory, sleep disorders.

Less common

Opposing effects include;

allergy, anemia, bloating, fatigue, tremor, pain, dizziness, vomiting, myalgia, back pain, breast pain, genital itching, genital yeast infection, upper respiratory tract infection, premenstrual tension, urinary tract infection, vaginal discharge, sweating, hyperventilation, vaginal dryness, fever, flu-like symptoms, dry mouth, rhinitis, leg pain, skin discoloration, skin disorders, sinusitis, acne.

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      rebeccaprogesteroneuser 7 years ago

      Many doctors believe the synthetics are real progesterone because of theirtraining. They are not purposely unaware. If you were to look up in thePhysicians Desk Reference you would in fact see under medroxyprogesterone acetate (thename for progestins - Provera - the most common, pregesterone, gestagens, progestogens andothers) a lengthy list of side effects including: Increased risk of birth defects if takenin the first 4 months of pregnancy, depression, miscarriages or congenial deformities in the fetus, breakthrough bleeding, cervical erosion, nausea, malignant mammary nodules inanimals, sudden loss of partial vision and many more.