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Indole 3 Carbinol Benefits: Thyroid And More

Updated on July 31, 2012

Indole 3 carbinol is a compound found in cruciferous vegetables such as cabbage, broccoli, kale and cauliflower. It has powerful antioxidant properties and the ability to increase the body’s anti-toxin enzyme activity. Studies have shown that it has been effective in the treatment of breast, ovarian and cervical cancers. Indole-3-carbinol has the ability to break down cancer causing estrogen and dioxin (a pesticide) rendering them harmless. In comparison with the popular anti-estrogen drug tamoxifen which is sixty percent effective against estrogen promoted cancer cells, indole-3-carbinol is ninety percent effective. When put to the test at the National Cancer Institute, indole-3-carbinol was found to be the most effective anti-cancer agent among eighty substances that were tested.

Treatment for non estrogen cancers have also shown promise such a Human Papilloma Virus (HPV) and its vocal cord related cancer papillomatosis, prostate cancer and lung cancer. Research has also shown that indole-3-carbinol may be valuable in the treatment of auto-immune disease such as multiple sclerosis, lupus and rheumatoid arthritis. In order benefit from the cancer fighting power of indole-3-carbinol, experts recommend a daily intake of between 200 and 400 mg, which is the range used in clinical trial for cancer prevention. Obtaining this amount from your diet may prove to be challenging.

Cooking cruciferous vegetables destroys a good percentage of the nutrients. If you consumed large amounts of raw broccoli, cauliflower, kale and cabbage for breakfast, lunch and dinner every day you would most likely get enough indol-3-carbinol. Making these vegetables a regular part of our diet is essential, but eating them all day just isn’t practical or desirable. The alternative is to add an effective supplement from a reputable company. To obtain maximum results from Indole-3-Carbinol it is important to eliminate estrogen promoting foods such as processed foods, simple carbohydrate foods and beverages and foods and beverages that contain toxic fats. Avoid personal and home care products containing chemicals that can be absorbed through the skin or inhaled.


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    • healthwriterbob profile image


      6 years ago from United States

      Hi Stevemark122000

      I was intrigued by your hub on indole-3-carbinol. Such a simple compound has so many potentially useful biological effects. It is available as a supplement from several suppliers, and there have been human clinical trials done with it for prostate cancer, breast cancer, endometrial cancer in obese women and other things. Thanks for the interesting information. I voted up your hub.

    • profile image


      8 years ago

      I'm reading up on this supplement... question, for someone who has ovarian cancer and has already had "everything down there" removed and done chemo (although unfortunately found more), can this still be helpful?(obviously not during chemo) Any particular brands that are considered "better"? Any other reputable literature on this topic? Thanks so much!

    • The Good Cook profile image

      The Good Cook 

      9 years ago

      I love cruciferous vegetables -- if I could think of a nice, tasty but quick way to have it for breakfast I would. Thanks.

    • gpetrou85 profile image


      9 years ago from greece

      very nice,good hub.

    • stevemark122000 profile imageAUTHOR


      9 years ago from Southern California

      Thanks for the great comments everyone! Hot dorkage you're hilarious.

    • hot dorkage profile image

      hot dorkage 

      9 years ago from Oregon, USA

      OMG the consequences of eating three large helpings of raw crucifers a day every day! I maybe would prevent the cancer but what good would that be because I would have no friends. Everybody would have to stay within the methane free zone which the police would delineate with crime scene tape around our house. And if someone lit a match within six feet of me it would be all over. I would be a walking biohazard!

    • profile image


      9 years ago

      Again you have given , pun intended, food for thought and done so well

    • frogyfish profile image


      9 years ago from Central United States of America

      Great info.  But help...the same veggies eaten raw tend to decrease the thyroid activity in hypothyroid people.   If you run across a 'neutralizer' for this I'd like to know.  Thanks!

    • RooBee profile image

      Arby Bourne 

      9 years ago from USA

      This is great! So refreshing to see this simple, intelligently assembled information on the healing powers of the flora of earth.

      I am intrigued by the Indole-3-Carbinol cancer studies and thanks to you will pursue this subject further.


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