Kratom, The Wonder Plant
Kratom, scientifically known as Mitragyna speciosa is a tropical evergreen deciduous plant under the coffee family which is predominant in the Southeast Asia in Malesia floristic regions and Indochina. People from the Southeast Asia have a long history of using Kratom leaves for herbal medicine. The leaves have some analgesic effect and have been used as pain killers in treatment of acute and chronic pain.The plant has also been used to treat cases of diarrhea and in treatment of opiate addiction.
In Thailand, Kratom leaves are chewed fresh after the removal of the central vein. Though chewing dried leaves produce similar effect, most people prefer chewing fresh ones as the former are tough. They are therefore crushed to make them easy to swallow with ease as powdered kratom can be easily mixed with water before consumption. Apart from mixing it with drinking water, you can as well make tea using the dried powder as the more appealing to consume as opposed to mixing it with water. The mixture can as well be converted into a paste and stored for future use. This is by evaporating the liquid in the mixture to obtain a paste.The stored paste can the be dissolved in hot water before intake. It is also practical to mix kratom with sugar or honey as this process acts to sweeten it and make it easily consumable.
There have been a lot of research going on the metabolism, pharmacokinetics and pharmacodynamics of kratom. Studies on the pharmacokinetics of mitragynine, the active compound in kratom have led to a great revelation of great importance in drug discovery and design.
Research has indicated that kratom has similar effect as opiate drugs. These is because it contains alkaloids that act as agonist against opiate pain receptors.The most fascinating aspect of kratom unlike other opiates is that it is lacks the addictive components hence can be used by patients without producing the addiction effect. These compound was exhibited some analgesic effect hence it is a promising compound for use in design of pain killers and as a replacement of the opiods which have a long history of use in clinical management of chronic pains.
It is important to note that because kratom has similar mechanism of action as opiates and that it also lacks the addiction effect, t can be used in treatment of patients withdrawing from opiates. This is based on the principle that kratom produces similar effect as opiates but does not make an individual dependent on it. Kratom is an opiate receptor agonist thus binds to the opiate receptors just like other opiates. The pharmacological effect of kratom however differs from opiates in an important and useful manner hence its use in opiate addiction cases.Patients who are exhibiting opiate withdrawal symptoms are subjected to a kratom dosage to manage the withdrawal symptoms before they fully withdraw. Most opiate addicts have reported that the usage of kratom has enable them withdraw from opiates without exhibiting withdrawal symptoms and that the withdrawal from kratom itself has no side effects.
Thailand as a country has placed a burn on the use of kratom in the country. This has made the research on Kratom using human subjects unethical and therefore most of the research work is done using model organisms.In the united states, several states have placed a ban on its usage however, it is still legal in a few states within the U.S. It is illegal to consume kratom in states such as Indiana and Ohio. States such as Arizona, Alabama, California and Colorado allow the usage of kratom at this time. Its usage in future in this states is however not promised as most states have in the recent past banned the usage of kratom. It would be of importance that research is quickly carried out of the substance using human subjects to create evidence that the policy makers can use in making decisions on matters concerning its usage.
In summary, it is worth noting that kratom is not a drug but it is a medicinal plant that has been in use since time immemorial more often in Southeast Asia. Its demand is increasing across the world and more research needs to be done to inform policy makers about its beneficial effects. Based in studies using model organisms, it is evident that the plant is more useful in management of pain and has less side effects as opposed to opiates. Clinical studies using human subjects should therefore be carried out to prove the efficacy of the plant.