ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Link Between Helicobacter Pylori and Parkinson's Disease

Updated on July 24, 2013
Helicobacter pylori under the microscope
Helicobacter pylori under the microscope | Source

US scientists have discovered a link between Helicobacter pylori and Parkinson's Disease.

Middle-aged laboratory mice were infected with the bacterium H.Pylori and they went on to develop symptoms similar to Parkinson's.

This exciting breakthrough could herald a new era of treatment of Parkinson's Disease which blights so many lives, similar to how the discovery of Helicobacter Pylori changed the lives of so many suffering from stomach ulcers.

The problem, however, with Parkinson's, is that by the time a patient is showing symptoms, neurons have been irreversibly damaged and cannot be repaired.

What are Neurons?

Neurons are nerve cells. We depend on neurons to transmit signals between the brain and the body.

If you want to pick up that pencil sitting in front of you, neurons send signals to your arms and hands, and you reach out and pick up the pencil.

People with neuron damage may find picking up the pencil an impossibility, even thought they want to.

H. Pylori and Parkinson's Disease - What the experts say

It is unclear at the moment how scientists can use this new discovery for the benefit of sufferers of Parkinson's Disease, but Dr Traci Testerman of the Louisiana State University Health Sciences Center is quoted as telling the BBC:

"Our findings suggest that H. pylori infection could play a significant role in the development of Parkinson's disease in humans.The results were far more dramatic in aged mice than in young mice, demonstrating that normal ageing increases susceptibility to Parkinsonian changes in mice, as is seen in humans".

She went on to elaborate "H. pylori eradication in late stage Parkinson's disease is unlikely to result in significant improvement.

"Certain neurons are killed before symptoms begin, and more are killed as the disease progresses. Those neurons will not grow back."

Meanwhile Dr. Kieren Breen, the director of research at Parkinson's Disease UK is reported to have told the BBC that while there is evidence that the presence of H.pylori can actually prevent the body's absorption of Levodopa, which is the main drug used to treat Parkinson's, there is no evidence to suggest that those people with H.pylori will go on to develop Parkinson's.

He went on to add: "The current study is interesting and suggests that the bacteria may release a toxin that could kill nerve cells.

However, the results should be treated with caution. The research was carried out in mice that were infected with relatively high doses of the bacterium or its extract.

While they developed movement problems, we don't know whether this was actually due to the death of nerve cells. Further research needs to be carried out".

H. pylori
H. pylori

What is Helicobacter Pylori?

Helicobacter pylori, often referrred to as simply H.pylori, is a bacterium that lives in the lower part of the stomach in humans. It does not exist in any other organism in the world. Many of us are infected with it from birth, and carry it in our stomachs throughout life with no apparent complication.

First discovered in 1982, by two Australian doctors, Robert Warren and Barry Marshall, the noted presence of H. pylori heralded a major breakthrough in the treatment of peptic and duodenal ulcers.

Up until then, those ulcers were responsible for years of misery for sufferers and the only treatment recommended was to take acid-inhibiting drugs to protect the stomach lining, and a change of diet and lifestyle.

Despite everything, those ulcers kept flaring up, bleeding and hospitalizing many patients, resulting in many cases in an untimely early death as well as precipitating stomach cancer, heart disease and many other inflammatory diseases such as osteoarthritis and Crohn's disease.

Like all bacteria, H.pylori can be eradicated with a simple course of antibiotics.

The breakthrough made by those two doctors that re-classified peptic ulcers as an infectious disease has revolutionized medicine, resulting in both doctors receiving the Nobel Prize for Medicine in 2005.

How heliocbacter pylori causes peptic ulcers
How heliocbacter pylori causes peptic ulcers | Source

What is Parkinson's Disease?

Parkinson's Disease is a degenerative disease of the nervous system characterized by shaking, rigidity, slowness of movement and difficulty walking.

It can strike any (adult) age-group, but tends to affect those over 50 more often.

Parkinson's occurs as a result of the death of dopamine cells in the brain, and the only treatment so far has been to replace that dopamine with the drug Levadopa and similar.

There is no cure, and the disease steadily progresses until the patient can no longer walk and loses cognitive power (the ability to recognise people and things around them).

The number of people diagnosed with Parkinson's Disease has been steadily increasing year in year out, and several famous people have been struck down with this horrific disease, notably among them Hollywood actor Michael J Foxand boxer Muhammad Ali.

Laboratory research
Laboratory research

Possible new cures soon with future research?

It is the link between dopamine and H. pylori which is exciting scientists.

Obviously the laboratory mice suffered a decrease or death of the dopamine cells in their brains with the introduction of H. pylori into their bodies - and remember as said above, H. pylori is a uniquely human bacteria - it does not exist elsewhere, so rats would have no immunity.

If H. pylori is inhibiting the absorption of Levadopa in patients with Parkinson's Disease, then a course of antibiotics should kill off the bacteria allowing those patients to live a normal life, with continuing treatment.

This breakthrough, discovering a link between Parkinson's Disease and Helicobacter pylori is tremendously exciting and we may indeed find some new wonder cures coming out inside the next 10 years, with further research.


    0 of 8192 characters used
    Post Comment
    • IzzyM profile imageAUTHOR


      8 years ago from UK

      Wouldn't that be something! I,too, have friends who are suffering from Parkinson's - it seems to have gone from being a rare disease to a relatively common one which ruins a lot of lives.

    • MPG Narratives profile image

      Marie Giunta 

      8 years ago from Sydney, Australia

      This is very interesting as H. pylori is quite common but often not diagnosed, many people don't even realise they have it. Look forward to further research in this and hopefully a cure for Parkinsons.

    • IzzyM profile imageAUTHOR


      8 years ago from UK

      I am fascinated with this latest finding. I remember when H.pylori was first discovered - the Reader's Digest carried a story about it. I wrote an article around it at the time, which of course I have lost now. But really, it was a major, major finding, and this latest one looks like it could be too.

    • Golfgal profile image


      8 years ago from McKinney, Texas

      So many illnesses come from the microscopic community. thanks for the info.


    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at:

    Show Details
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the or domains, for performance and efficiency reasons. (Privacy Policy)
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
    ClickscoThis is a data management platform studying reader behavior (Privacy Policy)