ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Lou Gehrig’s Disease - Amyotrophic Lateral Sclerosis

Updated on April 19, 2020
Pamela99 profile image

After 22 years as an RN, I now write about medical issues and new medical advances. Diet, exercise, treatment, and lifestyle are important.

Source

Facts about Lou Gehrig’s Disease

Fifteen new cases of Lou Gehrig’s disease, which is Amyotrophic Lateral Sclerosis (ALS), is diagnosed daily in the US. ALS is a progressive neurodegenerative disease, and it affects the nerve cells of the brain and spinal cord. This disease causes patients to slowly lose the ability to move, speak, eat or even breathe. The average life expectancy after this diagnosis is from 2 to 4 years, although 10% may live 20 or more years.

The motor neurons begin in the brain, then reach the spinal cord before reaching the muscles. The motor neurons progressively degenerate with ALS. When the motor neurons die, the brain is no longer able to initiate or control muscle, so there is no voluntary movement in the arms and legs. There is no cure for ALS.

MRI with the Diagnosis of ALS

MRI with increased signal in the posterior part of the internal capsule that can be tracked to the motor cortex, consistent with the diagnosis of ALS
MRI with increased signal in the posterior part of the internal capsule that can be tracked to the motor cortex, consistent with the diagnosis of ALS | Source

Types of ALS

There is no known cause of this disease for 90-95% of the people. Scientists believe that genetic and environmental factors are involved. The remaining 5-10% of cases are familial, which means inherited. The children that are born from parents that have this disease have a 50% chance of inherited the gene mutation and may develop ALS.

ALS can occur at any age but typically does not occur until ages 40 to 70. The familial disease may occur at age 50. More white people are affected than blacks. In Europe, this disease affects 2-3 people per 100,000 annually. Numbers are unclear for much of the world. Military vets also develop ALS at a higher rate regardless of the branch of the military where they served, and it does not matter whether they served during a war or during or peacetime.

Lou Gehrig - New York Yankees

Source

History of Lou Gehrig’s Disease

Charles Bell described this disease in 1824. Jean-Martin Charcot, a French neurologist, discovered the disease in 1869. He was the first one to call this disease amyotrophic lateral sclerosis as he noted the connection between the symptoms and neurological problems.

This disease became known in the United States when Lou Gehrig developed this disease in 1939. Since Lou Gehrig was a well-known first baseman for the NY Yankees with an excellent hitting record, and he was known as ‘The Iron Horse’ so people knew him and cared about his life. He was diagnosed at 36 and died at age 38. Then, Stephen Hawking developed this disease in 1963.

Lou Gehrig Disease

Source

I might have had a tough break, but I have an awful lot to live for.

-- Lou Gehrig

Symptoms and Treatment of ALS

Initially, symptoms of ALS are barely detectable. The initial characteristics are stiff muscles, muscle twitching, then, a gradually worsening muscle weakness. This is a difficult disease to diagnose and may take several months or even years.

While there is no cure, there are treatments to improve the symptoms, which is the goal at this time even though advances have been achieved. Riluzole is a medication used to extend the life of the patient by a few months.

Early symptoms of ALS:

  • Coordination and strength of the arms and legs may be the first symptoms.
  • Fatigue and weakness in the feet and ankles is another early symptom.
  • The muscles of the arms, tongue, and the shoulders may twitch or cramp.
  • Speaking, swallowing and breathing may become strained.

The patient may end up on non-invasive ventilation that will extend life for a period of time and have a feeding tube for nutrition. While these things may help the disease will continue to progress. Ultimately, most patients die of respiratory failure.

The Mayo Clinic lists the following possible symptoms:

  • Muscle cramps and spasms
  • Spasticity
  • Constipation
  • Fatigue
  • Excessive salivation
  • Excessive phlegm
  • Pain
  • Depression
  • Sleep problems
  • Uncontrolled outbursts of laughing or crying

Diagnosis and Treatment of ALS - Mayo Clinic

Studies Used to Reach a Diagnosis

Various medical tests may be conducted to differentiate this disease with other neurological diseases:

  • Electromyogram (EMG) - a test to check for electrical activity in the muscles
  • Nerve conduction test, which checks for the nerve's ability to send messages to the muscles
  • MRI to get detailed images of the brain and spinal cord
  • Urine and blood tests to look for abnormalities
  • Spinal tap to get a laboratory analysis
  • Muscle biopsy to rule out other diseases

Breathing care is a concern, and some people end up with a tracheostomy, Physical, occupational and speech therapy are treatments that may help the patient. Psychological and social support can help with financial problems, insurance issues, getting the appropriate equipment and emotional support may all be provided.

Slowing the advancement of this disease with medications is the only treatment at this time, but there is a vast amount of research ongoing, which hopefully will find a cure.

Treatment and Research News

Whie riluzole slows the progress of the disease, it is expensive. Spasticity may be controlled with baclofen and diazepam, but the available treatments for this disease does not reverse the damage.

Scientists seek to understand the exact mechanism that causes the motor neurons to degenerate. Research at this time have found a variety of cellular defects, which depend on the exact gene mutation. Another recent discovery shows the cells of the nervous system (glial support cells and inflammation cells) also play an important role in ALS. The ALS Association is support stem cell research using blood and skin cells.

Jingsong Zhou, a professor of kinesiology at the University of Texas, is investigating a new approach to ALS. Recently, she was awarded a $2.88 million award from the NIH to support her work that preserves the mitochondria, the way it works or dysfunctions in a diseased cell. She believes this disease affects the physiology of the whole body. Zhou is searching for the reason cells are damaged, then she hopes to test potential therapies or compounds.

Lou Gehrig's Disease (ALS): Progress and Promise in Stem Cell Disease

How to Cope with ALS

There are a few things you can do as a patient to help accept this diagnosis and live the life you have to the fullest extent.

  1. Time to Grieve - The news that you have ALS, which is a fatal disease, if very difficult for you and your family. A period of mourning is appropriate.

  2. Try to think beyond the physical changes as you can still lead a rewarding life despite the limitations.

  3. Remain hopeful - Having a healthcare team will help you focus on healthy living throughout the course of this disease. Patients sometimes live 10 or more years, so maintain an optimistic outlook to improve the quality of your life.

  4. Join an ALS support group as talking with others that have ALS can relieve some of the anxiety. There are also support groups for family members.

ALS is a difficult disease, and it is difficult to hear you have a disease that is so debilitating and has no cure. The research is ongoing throughout the world, and many researchers are looking for a cure. They have made progress.

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.

© 2019 Pamela Oglesby

working

This website uses cookies

As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://corp.maven.io/privacy-policy

Show Details
Necessary
HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
LoginThis is necessary to sign in to the HubPages Service.
Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
AkismetThis is used to detect comment spam. (Privacy Policy)
HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
Features
Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
MavenThis supports the Maven widget and search functionality. (Privacy Policy)
Marketing
Google AdSenseThis is an ad network. (Privacy Policy)
Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
Index ExchangeThis is an ad network. (Privacy Policy)
SovrnThis is an ad network. (Privacy Policy)
Facebook AdsThis is an ad network. (Privacy Policy)
Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
AppNexusThis is an ad network. (Privacy Policy)
OpenxThis is an ad network. (Privacy Policy)
Rubicon ProjectThis is an ad network. (Privacy Policy)
TripleLiftThis is an ad network. (Privacy Policy)
Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
Statistics
Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
ClickscoThis is a data management platform studying reader behavior (Privacy Policy)