ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Management And Special Types Of Acute Nephritic Syndrome (Goodpasture’s Syndrome)

Updated on February 6, 2014

Special Types Of Acute Nephritic Syndromes

The hypertension occurring in acute nephritic syndrome is often self-limiting and in most cases does not require any special treatment. If the blood pressure is high (diastolic above 110-120) and hypertensive complications are imminent,
The hypertension occurring in acute nephritic syndrome is often self-limiting and in most cases does not require any special treatment. If the blood pressure is high (diastolic above 110-120) and hypertensive complications are imminent, | Source

A General Overview

Complications arising during the course of the disease, such as hypertensive encephalopathy, cardiac failure with pulmonary edema, hyperkalemia and uremia demand active intervention.

The hypertension occurring in acute nephritic syndrome is often self-limiting and in most cases does not require any special treatment. If the blood pressure is high (diastolic above 110-120) and hypertensive complications are imminent, hydrallazine, methyl dopa or propranolol have to be used in adequate doses. If blood pressure rises rapidly or hypertensive encephalopathy occurs, parenteral reserpine 0.5- 1mg intramuscularly or diazoxide 100-200mg intramuscularly may be given. If convulsions continue in spite of antihypertensive therapy, lumbar puncture to release a small quantity of CSF may help in controlling seizures. This procedure is seldom resorted to these days.

Pulmonary edema is to be treated on the usual lines of left ventricular failure. Sedation with diazepam 10mg given intramuscularly or intravenously, oxygen inhalation, furosemide in large doses (often 100-200mg given intravenously) and slow intravenous injection of aminophylline may be helpful. If the diuretic does not bring about dieresis, pulmonary congestion can be effectively relieved by physiological venesection by applying tourniquets to the proximal parts of the limbs to prevent venous return. Open venesection in which 250-400ml of blood is removed from the antecubital vein can also be tried if facilities for more effective therapy are not available. Dialysis or ultrafiltration may be employed to removed the excess of fluid in these cases. Digitalisation has to be determined, based on the individual case. A course of penicillin is indicated if there is active infection by streptococcus.

Good Pasture's Syndrome In Diagram

This is a typical example of anti-GBM-antibody mediated glomerulonephritis. Antibodies against the glomerular basement membrane (GBM) and pulmonary capillary basement membrane are produced. These attach to the respective basement membranes and set up
This is a typical example of anti-GBM-antibody mediated glomerulonephritis. Antibodies against the glomerular basement membrane (GBM) and pulmonary capillary basement membrane are produced. These attach to the respective basement membranes and set up | Source

Goodpasture’s Syndrome

This is a typical example of anti-GBM-antibody mediated glomerulonephritis. Antibodies against the glomerular basement membrane (GBM) and pulmonary capillary basement membrane are produced. These attach to the respective basement membranes and set up inflammatory reaction. In the glomerular capillary basement membrane, the antibody appears as a linear deposit on immunofluoresence microscopy. This stands out in sharp contrast to the granular deposit of immune complexes seen in post-streptococcal acute glomerulonephritis. Renal histology shows proliferation of the epithelial cells of the Bowman’s capsule giving rise to the appearance of crescents. The disease presents with pulmonary symptoms such as hemoptysis and features of acute glomerulonephritis. The prognosis is generally unfavourable. Large doses of corticosteroids and immunosuppressive drugs have been tried but the results are not uniformly good.

Other conditions

Systemic lupus erythematosus, polyarteritis nodosa, Henoch-Schonlein syndrome, and infective endocarditis may give rise to acute nephritic syndrome during their course. Other evidence of the underlying disease is generally present. Treatment is for the primary disorder. Renal manifestations usually subside with the underlying condition.

© 2014 Funom Theophilus Makama

Comments

    0 of 8192 characters used
    Post Comment

    No comments yet.

    working

    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://hubpages.com/privacy-policy#gdpr

    Show Details
    Necessary
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
    Features
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Marketing
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Statistics
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)