ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Marfan's Syndrome

Updated on June 12, 2011

What is it?

  • A genetically inherited disease that affects the connective tissues of the body. It is an autosomal dominant condition, so even if only one parent has the gene for Marfan’s, the child can still inherit it. Only around a quarter of cases are completely new spontaneous cases in families.
  • The chemical composition of the connective tissue is not normal, causing problems throughout the body.
  • Causes the joints to be more flexible than they should be and the bones to grow longer and thinner than is usual.
  • It ranges from mild to very severe, depending on the person affected.
  • Is relatively rare, with only one in 5000 people being affected, men and women equally.
  • Caused by a defect in the FBN1 gene coding for fibrillin and elastic fibres, meaning that not enough fibrillin is made in the body, so parts of the body may stretch more than normal.


  • Symptoms mostly in the bones, eyes and cardiovascular system. They tend to get worse with increasing age.
  • Skeletal symptoms include being abnormally tall due to very long limbs with loose joints, overcrowded teeth, a protruding breastbone and a small bottom jaw. It can also cause further conditions such as scoliosis or spondylolisthesis.
  • Eye symptoms include short sight, lens dislocations, retina detachment, glaucoma and cataracts.
  • Cardiovascular symptoms include an enlarged aorta, as it will have weak walls (aortic aneurysm) or a prolapse of some valves such as the mitral valve (leading to blood leakage and therefore inefficient pumping of the blood).
  • Can also find stretch marks due to the weakened tissue underneath being stretched during growth, and lung tissue changes making the lungs more susceptible to problems like asthma.


  • Symptoms will be compared to the Ghent criteria. This is a list of symptoms that allows a GP to differentiate between this and other similar conditions.
  • Hospital tests like an echocardiogram or an MRI scan can also help to confirm some of the symptoms that cannot be seen, e.g. problems with the aorta.
  • Prenatal testing can be done to determine if a child from a Marfan’s Syndrome parent will also have the condition. This can be done via amniocentesis or chorionic villus sampling.

Treating Marfan's

  • There is no cure currently for this syndrome. There are however treatments to ease the symptoms of the condition.
  • Back braces or surgery to help with scoliosis.
  • Physiotherapy to help develop a wider range of movements.
  • Beta blockers to prevent heart damage.
  • Surgery for concaved chests.
  • Glasses or contact lenses to correct vision problems, and the removal of cataracts.


    0 of 8192 characters used
    Post Comment

    No comments yet.


    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at:

    Show Details
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the or domains, for performance and efficiency reasons. (Privacy Policy)
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)