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Most Essentially Potent Psychotropic Medication

Updated on October 5, 2019

Some of the most essentially potent psychotropic drugs encompass the following: Ambien, Lithium, Clozaril, Lexapro, Ativan, Valium, Latuda, and Adderall.

Some of the most essentially potent psychotropic drugs encompass the following: antidepressants, such as Lexapro (escitalopram), Zoloft (sertraline), Paxil (paroxetine), Valdoxan (agomelatine), Trintellix (vortioxetine), and Remeron (mirtazapine); antipsychotics, including Clozaril (clozapine), Latuda (lurasidone), Abilify (aripiprazole), Zyprexa (olanzapine), Risperdal (risperidone), and Seroquel (quetiapine); mood stabilizers, such as Lithium (lithium carbonate); anxiolytics, including Ativan (lorazepam) and Valium (diazepam); sedatives, such as Ambien (zolpidem); antihypertensives, including Tenex/Intuniv (guanfacine) and Kapvay (clonidine); and stimulant medications, such as Adderall (dextroamphetamine and levoamphetamine mixed salts), Vyvanse (lisdexamfetamine), and Ritalin/Concerta (methylphenidate).

The reason why the antipsychotics Abilify, Zyprexa, Seroquel, and Risperdal are ranked below the antidepressants is because, in the treatment of Bipolar Disorder, antipsychotics are typically only beneficial when augmented to enhance the effectiveness of the SSRI antidepressant (particularly with Zoloft, Prozac, Paxil, or Luvox).

This is the ranking of the most essentially potent psychotropic drugs:

1. Ambien (zolpidem) - insomnia (treatment resistant)

2. Lithium (lithium carbonate) - bipolar disorder (treatment resistant)

3. Clozaril (clozapine) - schizophrenia (treatment resistant)

4. Lexapro (escitalopram) - depression (severe/profound), anxiety

5. Ativan (lorazepam) - anxiety (treatment resistant), panic disorder

6. Valium (diazepam) - anxiety (treatment resistant), panic disorder

7. Latuda (lurasidone) - depression (treatment resistant)

8. Adderall (dextroamphetamine and levoamphetamine) - ADHD-PI (formerly ADD)

9. Vyvanse (lisdexamfetamine) - ADHD-PI (formerly ADD), binge eating disorder (BED)

10. Ritalin/Concerta (methylphenidate) - ADHD-PI (formerly ADD)

11. Zoloft (sertraline) - anxiety, OCD, depression, PTSD

12. Paxil (paroxetine) - anxiety, OCD, depression, PTSD

13. Valdoxan (agomelatine) - depression

14. Trintellix (vortioxetine) - depression

15. Remeron (mirtazapine) - depression

16. Effexor (venlafaxine) - depression, anxiety

17. Elavil (amitriptyline) - depression, anxiety

18. Wellbutrin (bupropion) - depression, seasonal affective disorder (SAD)

19. Prozac (fluoxetine) - depression, anxiety, OCD

20. Luvox (fluvoxamine) - depression, anxiety, OCD, PTSD

21. Abilify (aripiprazole) - schizophrenia, bipolar disorder

22. Seroquel (quetiapine) - schizophrenia, bipolar disorder, depression

23. Zyprexa (olanzapine) - schizophrenia, bipolar disorder

24. Risperdal (risperidone) - schizophernia, bipolar disorder

25. Haldol (haloperidol) - schizophrenia, bipolar disorder

26. Thorazine (chlorpromazine) - schizophrenia

27. Lamictal (lamotrigine) - bipolar disorder

28. Kapvay (clonidine) - ADHD-HI (formerly ADHD)

29. Tenex/Intuniv (guanfacine) - ADHD-HI (formerly ADHD)

30. Depakote (divalproex) - bipolar disorder

31. Cymbalta (duloxetine) - depression, anxiety

32. Celexa (citalopram) - depression

33. Desyrel (trazadone) - depression, anxiety

34. Strattera (atomoxetine) - ADHD-HI (formerly ADHD)


My opinion of what should be the most prescribed psychotropic drugs:

1. Zoloft (sertraline) - For Anxiety, OCD, & Depression

2. Paxil (paroxetine) - For Anxiety, OCD, Depression, & Co-Morbid Insomnia

3. Lexapro (escitalopram) - For Severe/Profound Depression

4. Latuda (lurasidone) - For Depression, & Co-Morbid Insomnia

5. Valdoxan (agomelatine) - For Depression

6. Trintellix (vortioxetine) - For Depression

7. Prozac (fluoxetine) - For Anxiety, & OCD

8. Luvox (fluvoxamine) - For Anxiety, & OCD

9. Wellbutrin (bupropion) - For Depression, & Seasonal Affective Disorder

10. Lamictal (lamotrigine) - For Bipolar Disorder

11. Vyvanse (lisdexamfetamine) - For ADHD-PI (formerly ADD), & Narcolepsy

12. Tenex/Intuniv (guanfacine) - For ADHD-HI (formerly ADHD), & Co-Morbid Insomnia

13. Kapvay (clonidine) - For ADHD-HI (formerly ADHD), & Co-Morbid Insomnia

14. Rexulti (brexpiprazole) - For Depression

15. Seroquel (quetiapine) - For Bipolar Disorder, & Co-Morbid Insomnia

16. Abilify (aripiprazole) - For Bipolar Disorder, & Co-Morbid Insomnia

17. Zyprexa (olanzapine) - For Schizophrenia, & Bipolar Disorder

18. Risperdal (risperidone) - For Schizophrenia, Bipolar Disorder, & Co-Morbid Insomnia

19. Adderall (dextroamphetamine and levoamphetamine) - For ADHD-PI (formerly ADD), & Narcolepsy

20. Ritalin/Concerta (methylphenidate) - For ADHD-PI (formerly ADD), & Narcolepsy

21. Desyrel (trazadone) - For Anxiety, & Co-Morbid Insomnia

22. Effexor (venlafaxine) - For Depression, & Anxiety

23. Elavil (amitriptyline) - For Depression, Anxiety, & Co-Morbid Insomnia

24. Remeron (mirtazapine) - For Depression

25. Spravato (esketamine) - For Treatment-Resistant Depression

26. Lithium (lithium carbonate) - For Treatment-Resistant Bipolar Disorder

27. Ambien (zolpidem) - For Treatment-Resistant Insomnia

28. Ativan (lorazepam) - For Treatment-Resistant Anxiety, Panic Disorder, & Co-Morbid Insomnia

29. Valium (diazepam) - For Treatment-Resistant Anxiety, Panic Disorder, & Co-Morbid Insomnia

30. Cymbalta (duloxetine) - For Depression, & Anxiety

31. Celexa (citalopram) - For Anxiety, OCD, Depression, & Co-Morbid Insomnia

32. Depakote (divalproex) - For Bipolar Disorder, & Co-Morbid Insomnia

33. Strattera (atomoxetine) - For ADHD-HI (formerly ADHD) with Co-Morbid Depression

34. Clozaril (clozapine) - For Treatment-Resistant Schizophrenia, & Co-Morbid Insomnia

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