Panhypopituitarism is a pituitary disorder caused by any condition that compresses or damages to the pituitary gland.
Examples of condition that damages the pituitary gland includes:
Tumors like meningioma, craniopharyngioma or lymphoma
Trauma and radiations can cause damage to pituitary gland
Autoimmune diseases like hemochromatosis, sarcoidosis, histiocytosis x.
Infections like fungi and parasites.
Causes of panhypopituitarism includes tumor, trauma, radiation, autoimmune diseases
How does panhypopituitarism presents itself?
The symptoms are based on which hormone is deficient
Men: This deficiency has no symptoms in men
Women: They will not be able to breastfeed after childbirth because lactation is inhibited.
2)Follicle-stimulating hormone FSH and Luteinizing hormone (LH)
Men: They will not be able to make testosterone and sperm. They will also experience erectile dysfunction and decreased muscle mass.
Women: This presents as amenorrhea; they will not be able to ovulate or menstruate.
Both men and women experience decreased libido, infertility and decrease in body hair, axillary hair and pubic hair.
An associated disorder here is a disorder called Kallmann syndrome which is characterized by:
decreased FSH and LH with adequate GnRH number
Anosmia which is a loss of the sense of smell
Renal agenesis in 50%
-Decreased FSH and LH
3)Growth hormone (GH) deficiency
Children: presents with short stature and dwarfism
Adults: have few subtle symptoms because they have hormones like cortisol, glucagon and catecholamines as stress hormones to cushion the effect.
The subtle symptoms include:
Increase in LDL and cholesterol levels
Reduced lean muscle mass
Now let’s talk about the diagnostic tests involved.
Hyponatremia: is a condition in which there is a decrease in the level of sodium (Na) in the body.This is common in secondary hypothyroidism and isolate underproduction of glucocorticoid. Potassium level is unaffected here because it’s an isolated even and aldosterone isn’t affected.
MRI detects compressed muscle Lesions on the pituitary gland.
Specific Diagnostic Tests For Each Hormone
Standard Blood Tests
Abnormality Confirmed With
Low thyroid-stimulating hormone (TSH) and low thyroxine levels.
Decreased TSH response to thyrotropin-releasing hormone (TRH)
Decreased adrenocorticotropic hormone (ACTH) and decreased cortisol level.
Normal response to cosyntropin stimulation of the adrenal.Cortisol will rise (adrenal is normal) in recent disease, but abnormal in chronic disease because of adrenal atrophy.An elevated baseline cortisol level excludes pituitary insufficiency.
Decreased luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels.Decreased testosterone level
No confirmatory test
Growth hormone (GH) levels low, but this finding is not helpful because GH is pulsatile and maximum at night.
No response to arginine stimulation. No response to GH releasing hormone (GHRH).
Prolactin level low, but not helpful.
No response to thyrotropin-releasing hormone (TRH)
Older and less useful tests
Insulin stimulation: Insulin converts glucose to glucagon, therefore, an increase in insulin leads to a decrease in the levels of glucose and an increase in the level of growth hormone (GH). Failure of GH to rise in response to insulin administration indicates pituitary insufficiency.
Metyrapone: Metyrapone inhibits 11 beta hydroxylase which decreases the adrenal gland output. This then increases the adrenocorticotropic hormone (ACTH) level in response to the decrease in cortisol. So, if the ACTH levels still remains low on administration of metyrapone, this indicates pituitary disorder.
In treating these disorders, you basically have to replace the deficient hormone.
Cortisone: in the case of cortisol deficiency
Thyroxine: in the case of thyroid hormone deficiency
Testosterone and estrogen
Recombinant human growth hormone: in the case of growth hormone deficiency.
Replace cortisone before starting thyroxine
The 2 hormones produced by the posterior pituitary gland are antidiuretic hormone (ADH) and oxytocin.
Oxytocin: This hormone helps in uterine contraction during delivery, but delivery will still occur even if it is absent because of the presence of other hormones like progesterone. There is no deficiency disease associated with oxytocin
Antidiuretic hormone (ADH): Deficiency of this hormone leads to central diabetes insipidus (CDI) characterised by decrease in the volume of urine, decreased blood concentration and increased urine concentration.
We talked about the definition, causes and signs and symptoms of Panhypopituitarism. We also looked at the different specific diagnostic tests and treatments available.
If you have any experience related to this condition that you will love to share, please feel free to.
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This content is for informational purposes only and does not substitute for formal and individualized diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed medical professional. Do not stop or alter your current course of treatment. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.
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