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Phosphatidylserine Supplement for Brain Health

Updated on December 26, 2012

Phosphatidylserine is sometimes spelled "Phosphatidyl Serine" or "PS" (for short).

Phosphatidylserine along with phosphatidylcholine (PC) are fatty substances that are known as phospholipids. They are the building blocks for your cell membranes. As such, phosphatidyl serine is found in every cell of your body. But it is most abundant in the brain. Perhaps this is because the brain has 100 billion brain cells and because phosphatidyl serine is especially abundant in the cell membranes of neurons. When your cell membranes breakdown, the cell dies. As such, cell membranes are very important to keep healthy.

Phosphatidyl serine helps to move nutrients into the cells and to eliminate waste from the cells. Your body can make phosphatidylserine and can get phosphatidylserine from foods. Although there are not that many foods that contain phosphatidyl serine.

There are also phosphatidylserine supplement available. Sometimes they comes as a "complex" with other ingredients. But do not confuse it with another supplement called "phosphorylated serine". They are not the same. Phosphatidylserine is the one you want.

Many PS supplements are derived from soy or other plant sources. These are preferred over those derived from cow brains for fear of transmission of animal diseases.

Phosphatidyl Serine supplements

Dr. Mark Hyman writes ...

"Using PS supplements have been proven effective in improving memory and cognitive function, boosting mood and stress reduction, improving attention and reducing aggression in children with ADHD. And it has no side effects!" [page 92 of The UltraMind Solution]

Paper by Parris Kidd PhD reports on some studies that showed ...

"that PS can help slow the mental decline associated with aging. ... that PS is a promising and safe dietary supplement, and a premier candidate for inclusion in any program aimed at the support of cognitive functions."

the paper also mentions phosphatidyl serine's "unblemished safety record" and "remarkable lack of side effects."

PS have been shown even to slow the mental deterioration of Alzheimer's and dementia patients.

Book: "Brain Longevity"

You do not have to wait until you show memory impairment in order to take phosphatidyl serine.

Dr. Khalsa calls phosphatidyl serine "an extremely beneficial brain tonic" and says ...

"Many studies indicate that PS is helpful for people with age-associated memory impairment. It also helps to optimize cognition in people who have no cognitive impairment." [page 257 of Brain Longevity]

In the book Why Do I Still Have Thyroid Symptoms? When My Lab Tests are Normal, Datis Kharrazian writes that Phosphatidylserine can help lower elevated cortisol and that ...

"Supplementing with PS has been shown to enhance cellular metabolism and communication; protect cells from oxidation damage; decrease anxiety; improve mood, motivation and depression; and enhance memory and cognition." [page 152]

More info on Phosphatidylserine says that doses over 300 mg can produce insomnia and upset stomach and that ...

"Not enough is known about the use of phosphatidylserine during pregnancy and breast-feeding. Be on the safe side and avoid use."

Phosphatidylserine may have drug interactions with Alzheimer drugs, glaucoma drugs, blood-thinning drug (warfarin/Coumadin), and drying medications (Anticholinergic drugs). So check with your doctor first.

Life Extension Magazine writes that phosphatidylserine should be taken with meals but not right before bedtime. This helps prevent any nausea from taking it on an empty stomach. Phasphatidylserine readily crosses the blood-brain barrier and some of the neurotransmitters it releases may make it harder to fall asleep.

Phosphatidylserine can help reduce high cortisol levels. But not recommended for those with already low cortisol levels.


Author is not a medical professional and may receive revenues from the display ads and links within article.


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