ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Provigil and Nuvigil - My Latest MS Fatigue Drug Experiment

Updated on March 6, 2019
Jen's Solitude profile image

I've been living with MS for 25+ years and have tried almost every medication available. I have also been evaluated and tested extensively.

Nuvigil, the offshoot of Provigil, is one of the "new" drugs being touted as a weapon to help combat MS-fatigue. Provagil is the most common way Provigil is searched by Google users. Seemed only fitting, therefore, that this misspelling be included. Just for the record however, it is Provigil not Provagil.

Having had no positive effects from a past attempt at using Provigil, I am now experimenting with its successor, Nuvigil and decided it might be beneficial to write about my experience and the drug itself. I dare to hope it will resurrected me back to active status no longer being controlled by an exhaustion so severe it leaves me bedridden too much of the time.

4-Day Trial Results

Nuvigil did not fulfill my hopes. My experiment with the drug has now come to a disappointing end. The side effects were trumped by an apparent allergic reaction to the formula used to produce the drug.

My hoped for fatigue-reducer ended up increasing my fatigue which brings me to one of the ironies of some drugs. They produce the exact effect you are trying to avoid. Nuvigil lists as two of its possible side effects, tiredness and insomnia. So, the drug I hoped would rid me of mind numbing chronic fatigue, could give me insomnia, which of course would make me tired and dare I say it, FATIGUED. How then is Nuvigil useful to me? The answer - it isn't.

Of course, they were not the only side effects I tried to endure. First came the dizziness, followed by diarrhea, nausea and headaches. I was willing to put up with the early side effects in the hope that they would subside after a couple of days. Unfortunately, in my case the side effects intensified. It became clear on day 4 that this was not going to be a match I would be able to live with. Just as my husband and I discussed and concluded I would quit taking the drug, later that night I began to break out with terrible itching. Itching and/or hives is listed as one of the side effects that would cause immediate discontinuation.

HOPES DASHED

In the beginning of this short-lived experiment, I was very excited because I could feel a slight energy increase. By day 2 I was sure of the improvement. I anxiously, but optimistically awaited day 3, which for reasons still unknown to me, found the drug no longer providing anything but negative side effects. As my energy level returned to its previous mark, the side effects of the drug became more intense and what were occasional waves of discomfort became rolling tides of nausea and dizziness and diarrhea. I went from excited and enthusiastic, to disappointed and forlorn, feeling deserted and left to fend for myself by this drug I hoped would be my ally against the fatigue.

In Recovery Mode

Apparently, all I managed to achieve with my Nuvigil experiment, was to make myself more tired and more physically ill than had I left Nuvigil alone. My system is ridding itself of the drug and I do feel better as it leaves my system.

I must handle the increased fatigue, which will not relent just because the drug has left my building. It takes total bed rest to build my system back up to sheer exhaustion, so I am in the process of doing this as I type

I know other people with MS have had success with either Provigil or Nuvigil. I don't know why my body won't respond. I no doubt ask the same questions other MSers ask, who can't find the right drug to fight their fatigue.

Meanwhile, I will continue with my supplements and am considering one last try with one last known drug that has been successful in helping fatigue. That decision isn't final, as I find myself in recuperation mode, not ready to put my system through anything else just yet.

A Final Note

In conclusion, I should mention that it has been purported that shift workers benefit from Nuvigil as well as some who have narcolepsy or other sleeping disorders. So while the drug was not a success with me, it is being used successfully by others.

No doubt the manufacturers are happy that this new version of an old drug is being tried and even recommended by so many professionals. Their patent is about to expire and if Nuvigil is accepted, their profits will continue.

For those of us who just want relief not profits, this type of process can be depleting on one's sense of hope. Hope is best suited when it springs eternal, but when met with continued failure, one can't help but wonder if acceptance wouldn't provide a better fit.

I guess we all have to do some serious soul searching on an individual basis to come with the answer. Right now I am leaning towards acceptance as my best fit. Maybe that is only because the present failure is still very fresh in my mind. Perhaps, given some time and improved health, I will find my hope again and dare to dream once more that there is a drug out there for MS-related fatigue, with my name on it. 

working

This website uses cookies

As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://corp.maven.io/privacy-policy

Show Details
Necessary
HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
LoginThis is necessary to sign in to the HubPages Service.
Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
AkismetThis is used to detect comment spam. (Privacy Policy)
HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
Features
Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
MavenThis supports the Maven widget and search functionality. (Privacy Policy)
Marketing
Google AdSenseThis is an ad network. (Privacy Policy)
Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
Index ExchangeThis is an ad network. (Privacy Policy)
SovrnThis is an ad network. (Privacy Policy)
Facebook AdsThis is an ad network. (Privacy Policy)
Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
AppNexusThis is an ad network. (Privacy Policy)
OpenxThis is an ad network. (Privacy Policy)
Rubicon ProjectThis is an ad network. (Privacy Policy)
TripleLiftThis is an ad network. (Privacy Policy)
Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
Statistics
Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
ClickscoThis is a data management platform studying reader behavior (Privacy Policy)