Scientific Benefits of CBD Oil
Scientific Benefits of CBD Oil
I found out about CBD oil from a friend. The friend mentioned that they bought CBD oil online and that it was supposed to be administered sublingually (under the tongue) through a few drops. They didn't like the taste or the way it made them feel. I was immediately on alert, as I thought that maybe CBD oil was perhaps not permitted, as it was a derivative of hemp. I did a bit more analysis and found out that CBD oil, while a legal derivative known as hemp, has scientific, therapeutic evidence. The friend was taking it for depression, but I was surprised to know that CBD oil had many other scientific benefits as well. I chose to only use peer-reviewed, scientific journals as the basis of any CBD health claim. I also ensured that the scientific journals and peer-reviewed articles were recent, at least within the last five to ten years.
What is CBD oil?
CBD oil is usually known as 'hemp.' CBD is the shortened version of the word 'Cannabidiol.' It is one of the eighty-five chemical components that are commonly referred to as cannabinoids, which are located within the plant itself. Cannabidiol is abundantly found in hemp, being the second highest chemical component found in hemp.
CBD Oil and Cervical Cancer
In 2016, there was a study done that noted how CBD oil extract inhibited the growth of cervical cancer cells. The article went on to mention how cervical cancer is a significant issue for women, especially in women from Sub-Saharan Africa. About twenty-five percent of the women have been dying of cervical cancer every year. The study found that cannabidiol prevented cervical cancer cell growth, and it also induced the death of cervical cancer cells. The study mentioned that cannabidiol also was a great tool to fight against many disorders of a neurodegenerative nature, and also against diseases of the autoimmune order. (Lukhele, 2016)
CBD Oil, Drug Addiction, and Hepatic Toxicity
This study wanted to see if they can use CBD oil extract as a kind of treatment for those who are suffering from certain drug addiction. It's been quite a topic in the news, as drug dependence is reaching new heights for many reasons. Whatever the reasons, it leaves devastating effects on the patient and the patient's families. It appears that various chemicals called phytocannabinoids have an interesting effect on one's sensitivity to drugs. CBD oil extract (or cannabidiol) seems to lessen behavior that is considered 'habit seeking,' and it also has a lower potential for abuse. CBD oil extract has anxiolytic properties, and also a low incidence of side effects. Anxiolytic means that CBD oil helps to reduce anxiety. This paper used animal and human subjects for the clinical investigations and ultimately showed that CBD oil showed strong evidence for preventing certain drug relapse, so it should be further researched as a therapeutic intervention method. (Hurd, 2015) Certain drugs produce heart attacks, seizures, and liver injury. The liver injury causes intense inflammation within the organ. CBD oil helps protect against this kind of toxicity. It also prevents associated seizures related to liver inflammation. (Vilela, 2015) CBD oil has also lessened the duration of the drug in mice. In the animals laced with certain drugs, it was shown that the substance increased glutamate release, while CBD oil extract has quite the opposite effect. Glutamate is a powerful neurotransmitter that is released by the brain's nerve cells.
CBD Oil and Psychiatric Disorders
CBD has a high safety profile and may be able to treat psychosis, anxiety, and depression. Animals, such as rats, were used to test the anti-anxiety effects of CBD oil extract. It was noted that the rats had lessened defense behaviors when exposed to a predatory creature. Usually, exposure to such a predator would create panic attacks in the rats and even induce PTSD, or post-traumatic stress disorder. Many mice are prone to what is known as 'marble-burying.' CBD oil extracts less this behavior, which shows that it may have a positive effect in lowering OCD behavior in humans. The CBD oil was also seen to block particular learning and memory of events that are negative, which has been associated with pathophysiology regarding PTSD. According to the study, the mental impairment to fear was long lasting, and in the study of the rats, it lasted twenty-two days. (Campos, 2012)
CBD Oil and Epilepsy
The study began with mentioning that CBD has been used to treat many disorders ever since ancient times. Evidence has been seen where the CBD plant was used in Chinese medicine ever since 2700 BCE for several disorders, including inflammation, pain, and nausea. The CBD oil's extract may have anticonvulsant properties. This may be because CBD oil has anti-inflammatory properties, and is considered a 'neuroprotective.' CBD oil acts as a 'blocker of the equilibrated nucleoside transporter. It also 'enhances the activity of the 5-HT1A Receptor. It even 'activates the nuclear peroxisome proliferator-activated receptor,' and finally, it has a polyphenolic nature, which marks CBD oil as a potent antioxidant. Polyphenols are found in vegetables, fruits, wine, and even chocolate. Items high in polyphenols fight cell damage on a molecular level. (Devinsky, 2014)
CBD Oil on Oxidative Stress
Oxidative stress has everything to do with antioxidant properties. Oxidant stress is the balance amidst the oxygen in the blood and the free radicals. Free radicles may cause tissue damage, cell death and cell mutation within the human body. Free radicals are unstable, and much like air turns an apple brown, human cells can 'rust' when one breathes in air, especially foul air. When the body goes for long periods of time in oxidative stress, organs can become damaged, and they may start to dysfunction over time. It appears that CBD oil extract may activate the immune system and fight off oxidative stress. The paper mentions that CBD oil is a resorcinol based compound that has antioxidant effects due to its cyclic voltammetry nature. Unlike BHT or butylated hydroxytoluene, CBD oil did not promote any kind of tumors. CBD oil also prevented cell death that happened due to a deprivation of serum in human and mouse cells. (Booz, 2011)
CBD Oil and Disc Degeneration
This paper studied the effects of CBD oil on Lesion Induced Disc Degeneration of an intervertebral nature. It mentioned that disc generation is a process that involves inflammation, reduction in glycosaminoglycan, and even hypoxia. Hypoxia is when less amount of oxygen reaches the tissues. In a study, Wistar rats with tail disc injury were given CBD injections, and the results were looked at with an MRI or magnetic resonance imaging. It appeared that those rats injected with CBD oil weakened the disc injury effects induced by the puncture of the needle. The injection site was inspected fifteen days after the CBD oil injection. CBD oil may have a future for use within the realm of disc regeneration treatment. (Silveira, 2014)
Many rumors are circulating many different kinds of essential oils. CBD oils are becoming more popular, due to the loopholes surrounding its legality and usage. Ultimately, CBD oil is an excellent anti-inflammatory tool, as well as an anti-convulsant. It's also used as an antioxidant, anxiolytic (to fight anxiety, and even an antipsychotic. It may even help fight cancer and recover from an hard substance addiction while protecting the liver after heavy strong substance use. It has been shown to reduce PTSD symptoms as well. Regardless of its controversial nature, CBD oil has scientifically proved to be an innovative medicinal plant, derived from nature that could make a huge difference, when used correctly, in the therapeutic world.
Booz, G. W. (2011). CBD as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress. Free Radical Biology & Medicine, 51(5), 1054–1061. http://doi.org/10.1016/j.freeradbiomed.2011.01.007
Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S. (2012). Multiple mechanisms involved in the large-spectrum therapeutic potential of CBD in psychiatric disorders. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1607), 3364–3378. http://doi.org/10.1098/rstb.2011.0389
Devinsky, O., Cilio, M. R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., … Friedman, D. (2014). CBD : Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791–802. http://doi.org/10.1111/epi.12631
Hurd, Y. L., Yoon, M., Manini, A. F., Hernandez, S., Olmedo, R., Ostman, M., & Jutras-Aswad, D. (2015). Early Phase in the Development of CBD as a Treatment for Addiction: Hard Substance Relapse Takes Initial Center Stage. Neurotherapeutics, 12(4), 807–815. http://doi.org/10.1007/s13311-015-0373-7
Lukhele, S. T., & Motadi, L. R. (2016). CBDrather than CBD sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complementary and Alternative Medicine, 16(1), 335. http://doi.org/10.1186/s12906-016-1280-0
Silveira, J. W., Issy, A. C., Castania, V. A., Salmon, C. E. G., Nogueira-Barbosa, M. H., Guimarães, F. S., … Bel, E. D. (2014). Protective Effects of CBD on Lesion-Induced Intervertebral Disc Degeneration. PLoS ONE, 9(12), e113161. http://doi.org/10.1371/journal.pone.0113161
Vilela, L. R., Gomides, L. F., David, B. A., Antunes, M. M., Diniz, A. B., Moreira, F. de A., & Menezes, G. B. (2015). CBD Rescues Acute Hepatic Toxicity and Seizure Induced by Hard Substances. Mediators of Inflammation, 2015, 523418. http://doi.org/10.1155/2015/523418
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