Alzheimer's disease; funny tips for a global dementia epidemic with no cure; but coffee and Vitamin B12, may help?
Weird facts about coffee and Alzheimers
Alzheimer disease (AD), or Dementia of the Alzheimer type (DAT)
It seems expresso coffee and Vitamin B12 and gut-bugs are all linked to the global Alzheimers epidemic among people over 60. You also stay safer if you have a lot of leisure activities. Also a new idea based on refined human urine to make stem cells promises a solution.
May start near age of 60: Alzheimers forms the most common cause of dementia in the elderly. A survey of epidemiologic studies reports a range of up to 50 of each 1000 older people over about 60 with Dementia of the Alzheimer type: Incidence increases with age with up to 40 percent of those over the age of 85 years, with the condition.
- advanced age;
- female gender;
- carrying the apolipoprotein E (APOE) ε4 allele;
- current smoking;
- family history of DAT or other dementia;
- fewer years of formal education, lower income, and
- lower occupational status
The burden on the caregiver and the economy is high: Issues related to the care of persons with dementia of the Alzheimer type, including caregiver burden, long-term care, and the proliferation of dementia special care units. Increasing dependency, personality changes, and neuropsychiatric symptoms such as aggression/agitation and depression are also highly distressing to the caregiver.
Caregiver needs care: Providing assistance to a loved one afflicted with DAT comes at a considerable emotional, psychological, and physical cost to the caregiver.
The cost to the informal caregiver: Informal caregivers report:
- higher levels of depression and anxiety;
- lower overall life satisfaction;
- engaging in fewer preventive health behaviors;
- face increased risk of illness;
- higher risk of mortality;
- social isolation;
- financial strain; - employment complications: and
- disruption of relationships.
Institutionalized before death: Caregiver exhaustion, and the increased need for patient supervision lead to 90 percent of patients with dementia institutionalized before death. Among new admissions to nursing homes, the prevalence of dementia is nearly 70 percent.
In appears as progressive neurodegenerative disorder that gradually robs the patient of cognitive function and eventually causes death.
How long to death; In a study that followed persons with Alzheimer disease (AD), or Dementia of the Alzheimer type (DAT) for an average of 4 years, 54 percent were institutionalized and 49 percent died.;
- median survival is estimated at 11.8 years;
- mortality is strongly related to rate of cognitive decline
This starts with losing your house keys? And forgetting names and may leads to "behavioral and psychological symptoms of dementia, such as aggression/agitation, depression, apathy, anxiety, delusions, and hallucinations". In the early clinical stage, deficits occur in episodic memory, verbal abilities, visuospatial functions, attention, and executive function. Neuropsychiatric symptoms include such as forgetfulness and emotional and impulsive behaviors
More women get AD than men: Alzheimer disease accounts for 60 per cent to 70 per cent of cases of progressive cognitive impairment in elderly patients. About twice as many women get Alzheimers
Well-educated people may decline faster: High educational attainment was also associated with an accelerated rate of cognitive deterioration in DAT patients.
An interdisciplinary team of scientists at the University of Newcastle has developed a discovery of a simple blood-based test to identify people in the early stages of Alzheimer's disease.
The study was said to makes a considerable step towards cheap, non-invasive testing by identifying a blood protein panel to predict Alzheimer's disease in its early stages.
The test was not yet available. Alzheimer's disease was related to low blood pressure. That is persons with low blood pressure were more likely to end up with Alzheimers disease.
For example Chicago Health and Aging Project (CHAP), a study of 6,162 residents at age about 65 years, used a stratified random sample of 729 participants for clinical evaluation; of these
- 709 had blood pressures measured, and
- 243 were diagnosed with AD.
Low low systolic pressure (<130 mmHg) an Alzheimers risk: In the logistic regression models adjusted for age, sex, education, and race there was no association between blood pressure measured as a continuous variable and Alzheimer's disease. But - prevalence of Alzheimer's disease was significantly higher:
- among persons with low systolic pressure (<130 mmHg) compared
- with the referent group of 130–139 mmHg.
High systolic and diastolic categories were not statistically different from the referent group, although there was some evidence that the associations differed by race.
Vitamin B12 reduces Alzheimer disease symptoms
Vitamin B12 increases blood flow to the brain.
Blood–brain barrier (BBB) impairment is a stable characteristic over 1 year and present in an important subgroup of patients with Alzheimer disease. Vitamin B12 aids the blood–brain barrier
Alzheimer disease risk inherited: The APOE ε4 allele, a strong genetic risk factor for DAT, is associated with a greater risk of developing DAT.
Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, causes progressive cognitive decline and degeneration of synapses and neurons
Alzheimer'sdisease is characterized by deposition of amyloid β (Aβ) in cortical and leptomeningeal vessel walls.
Aβ accumulates five times more frequently around arteries than around veins, with selective involvement of smaller arteries.
Initial deposits of Aβ occur at the periphery of arteries at the site of the putative interstitial fluid drainage pathways.
These observations support the hypothesis that Aβ is deposited in periarterial interstitial fluid drainage pathways of the brain and contributes significantly to cerebral amyloid angiopathy in Alzheimer's disease.
Some people inherit potential for Alzheimer'sdisease: Excessive Aβ-CAA formation can be caused by several mutations in the Aβ precursor protein and presenilin genes.
The case for Vitamin B12
What happens when you run short of Vitamin B-12: You forget names and get confused and repeat yourself and lose the ability to plan.
Why? " Vitamin B-12 deficiency, such as macrocytic anemia and neurological complications affecting sensory and motor function, more subtle effects have also been described, including osteopenia, neurocognitive impairment, and increased vascular disease risk associated with elevated homocysteine".
Cause of low B12: "There is mounting evidence that Helicobacter pylori plays a role in diseases that lead ultimately to vitamin B-12 malabsorption and deficiency, from chronic atrophic gastritis to possibly even pernicious anemia..".
How to avoid Alzheimer’s disease
- Drink wine and take aspirin? Reduced risk of Alzheimer’s disease was linked to:
- use of nonsteroidal anti-inflammatory drugs;
- wine consumption;
- coffee consumption; and
- regular physical activity;
- lots of leisure interests;
Exercise and avoid pollution and pesticides and alcohol: Regular physical activity could be an important component of a preventive strategy against Alzheimer’s disease and many other conditions.
Defoliants and fumigants: AD was also connected with a history of migraines and occupational exposure to defoliants and fumigants. In Japan moderate physical activity had a statistically significant preventive effect. As did a stroke, systolic blood pressure, and alcohol consumption.
Hobbies a protection; Engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease. As risk of dementia was decreased in subjects with high leisure activities.
Electromagnetic field exposure increases risk: A survey of Swedish twins reared apart showed Electromagnetic field exposure increased risk of old age dementia. This was found to have an effect from the last occupation of the demented twin. It was suggested this was some kind of trigger effect or compound effect, which increased likelihood of dementia on retirement.
Four cups of coffee a day for women: It appears while ground coffee make you smarter in tests, it does not protect against Alzheimer’s disease.
At first it appeared ground coffee was a protection against Alzheimer’s disease but it was then found that a higher IQ and a higher social class at age 11 tended to lead to better health and a lower incidence of Alzheimer’s disease. So it was not coffee. Just that smarter, better educated people made different diet and lifestyle choices.
In a large prospective study, in the UK women who drank more than three cups of coffee per day showed less decline in verbal cognitive functioning and visuospatial memory over a 4-year period than women who had low or no consumption of coffee However, no effect was observed in men.
Burt how much coffee was measured? One cup of instant coffee can contain between 21 mg and 120 mg of caffeine, whereas the equivalent serving size of ground coffee (filter, espresso, etc.) can contain up to 254 mg ..
Further study showed ground coffee made you smarter: In the UK, ground coffee intake had a positive effect on verbal intelligence performance. Tea consumption was higher in the “lower” social classes, whereas those who drink coffee were more likely to belong to the “higher” social classes. The age 11 IQ was also predictive of tea or total coffee intake in late life; higher- IQ children were more likely to drink coffee, whereas poorer performance on the age 11 test was linked with a preference for tea, some 60 years later.
The caffeine effect: Men and women with the highest consumption of caffeine were less likely to have ever had diabetes, high blood pressure, and high cholesterol than those drinking less caffeine.
Ground coffee drinkers start out with a higher IQ and social class; "Second, the only indication that caffeine consumption exerts a protective influence on cognitive performance was that drinkers of ground (filter and espresso type-) coffee performed better on tests of verbal intelligence (NART and WTAR) than nondrinkers of ground coffee, even when controlling for age 11 IQ and social class".