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Stem Cell Transplant is not Dangerous - Save a life
Stem Cell Collection Machine
The Donor of Stem Cells - Self
Bone Marrow Transplant - Serious Anti-Cancer Therapy
Patient's guide to Leukemia
Cell Transplant Awareness - My experience
My family were shocked when we heard that my sister is suffering from leukemia. Just few hours before she was confirmed cancerous,she spoke to us. She went with persistent general pains all over the body, and occasional fever and thorough medical tests resulted in the deadly disease leukemia.
My mother is an 80 years old went in tears and but gained courage only to boost my sisters morale and confidence.
The hospital experts administered chemotherapy for 2 months and in the mean time my sister lost all her charm, lost heir,weight but she was mentally strong. She proved that mental strength and positive thinking will help patients a long way. The doctors at Hackensack Medical center in New Jersey, United States of America (ranked number 4 in cancer treatment in New Jersey) suggested chemo followed by bone marrow transplant or stem cell transplant for longer life. They preferred siblings for the stem cell transplant.
while continuing initial treatment followed by chemo in the hospital , my sister started a donor awareness campaign in the local temple premises at New Jersey. The campaign was partially successful. Many are reluctant to donate and few of them were ready for swap test also called human leukocyte antigen (HLA) test. In this test they collect saliva sample and conduct a series of tests for matching parameters with the patient. Surprisingly in stem cell transplant treatment (unlike kidney transplant) there is no need for a blood group match. From around 40 samples collected for the swap test the HLA results did not match with my sisters HLA parameters. Then they look around for siblings and I am informed to go for swap test.
I stay in India and in India there is no diagnostic center for high resolution swap test and with great difficulty sent the swap samples to USA for the tests. I was little confused about this new treatment even though I am more than willing to offer this little help to my sister.
When my swap samples matched hers, the chief doctor was very happy and sent a letter inviting me to USA and help my sister. before I went to USA as a donor I had hectic search for details on bone marrow and cell transplant the pros and cons and post transplant effects. Even though I understood the details through net I am not fully convinced and worried about the consequences. The following details I noted on Bone Marrow and Stem Cell Transplant methods of collection.
But after I met the team of doctors at the hospital I understand that
1. Bone Marrow transplant is a tedious process but Stem Cell transplant is fairly simple one. In stem cell transplant they collect the blood and through a process separate the stem cells and send the blood back into the donor body. It all will be in one sitting and for 4 to 5 hours.
To increase the stem cells in the donor's body they give 3 shots of Neupogen ( an injection that increase the stem cells for three days. These injections have some effects. You have lower back pain, bone pain, vomiting, weakness for few days to few months depending on the donor body condition.
The stem cells then will be transplanted into the patients body. The stem cell reach the bone marrow in a normal way and start producing blood cells. Before this stem cell transplant they do a final chemo and remove all cancerous cells from the patient's body. Now the new blood cells collected from donor will be cancer free cells and produce cancer free blood. That is all..
The stem cell transplant is just like blood collection and not painful nor dangerous. for more details contact me at my email. wish this page increase the awareness and my objective is met
How to become a stem cell donor?
- BMDW: Become a stem cell donor
BMDW is a project for the collection of the HLA phenotypes of volunteer bone marrow donors and cord blood units, and for the coordination of their worldwide distribution.
Hackensack University Medical Center for acute myeloid leukemia
- Hackensack University Medical Center, New Jersey - About Us | Hackensack University Medical Center
Ranked No 4 in USA medical Centers in USA , New Jersey Hackensack Hospital is an articulated and dedicated group. My sister is cured of acute myeloid leukemia in this hospital an year ago.
Chronic Myeloid Leukemia - A patient's Journey
Methods of Stem Cell Collection
The details below are extract from http://www.nhlcyberfamily.org/treatments/collection.htm
Method of collection
There are two methods for collecting enough Stem Cells for a transplant. Both methods apply equally to autologous or allogeneic donations.
Originally the collection was done by putting the donor under a general anesthetic, and using a series of needles to extract bone marrow directly from the large bones, usually the pelvis. This was a relatively simple procedure but still has the same risks as any procedure which uses a general anesthetic. The donor would feel no pain during the procedure, but would usually experience moderate pain for a few days after. This is the procedure they are referring to when you hear the term "Bone Marrow" harvest. (Harvest referring to the product collected from the donor)
The second type of harvest is the Peripheral Blood Stem Cell harvest. Bone Marrow collections have largely been abandoned in favour of this safer and better procedure. In a Peripheral Blood Stem Cell harvest, the donor is seated comfortably in an easy chair. An IV is placed into each arm. Blood is drawn out of one arm, sent to the aphaeresis machine where the CD34+ stem cells are separated, the the remaining blood is sent back into the IV in the other arm. In some cases a central venous catheter will be put in place if the patient does not appear to have veins capable of accepting the IV needles.
Peripheral Blood harvests have several advantages. The biggest and most important advantage is that the patient recovers faster, and with fewer major complications, when they receive a peripheral blood stem cell transplant, than if they receive a bone marrow transplant. Obviously anything that offers a survival and recovery benefit is of prime importance. Some other advantages are:
- No general anaesthetic is required for the donor
- The procedure can be repeated if enough are not collected the first time
- There is little or no pain to the donor during the collection procedure, although the Neupogen to mobilize the stem cells usually causes mild to severe bone pain as the marrow goes into overdrive producing more blood and stem cells. This bone pain can be quite severe for some, but is usually managed quite well with Tylenol or other OTC pain medications for most.
- There is a lower risk of collecting cancerous cells in an autologous harvest.
Because of these advantages, bone marrow harvests are not used very often. They are still used when the donor cannot harvest enough peripheral blood stem cells.
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Popular Hospitals in New Jersey for acute Myelogenous Leukemia Treatment
There are many more hospitals in USA taking care of cancer patients. There is real research break through in cancer treatment resulted in bone marrow transplant - A tedious procedure to much simpler stem cell transplant. Thanks to science advancement.