ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

The Clinical Manifestations Of Goitre: Simple Goitre, Endemic Goitre And Sporadic Goitre

Updated on February 9, 2014

Parenchymatous goiter

Iodine deficiency, iodine excess, dyshormonogenesis and the presence of goitrogens cause thyroid enlargement.
Iodine deficiency, iodine excess, dyshormonogenesis and the presence of goitrogens cause thyroid enlargement. | Source

Physiological Goitre

This is simple enlargement of the thyroid in puberty and pregnancy. It generally subsides when the physiological stress is over, or it may persist.
This is simple enlargement of the thyroid in puberty and pregnancy. It generally subsides when the physiological stress is over, or it may persist. | Source

Simple Goitre

Enlargement of the thyroid gland is known as goiter. A benign diffuse enlargement is called “simple goiter” or nontoxic diffuse goiter (NTCG).

Simple goiters: May occur due to different causes:

  1. Physiological goiter: This is simple enlargement of the thyroid in puberty and pregnancy. It generally subsides when the physiological stress is over, or it may persist.
  2. Parenchymatous goiter: Iodine deficiency, iodine excess, dyshormonogenesis and the presence of goitrogens cause thyroid enlargement.
  3. Colloid goiter: The acini are filled with colloid.

Nodular goiters and Toxi goiters- Primary (Grave’s disease) or secondary (Plummer’s disease).

Simple Goitre

This may be endemic or sporadic. Puberty goiter, colloid goiter and parenchymatous goiter are included in this group. The thyroid gland is diffusely enlarge, painless and non tender. It may be soft or firm in consistency.

Etiology: Simple goiter is the result of relative iodine deficiency which occurs during periods of increased demand for thyroid hormones, such as menarche and pregnancy. The gland enlarges due to hyperplasia and hypertrophy. When the stress is over or it is corrected, the cells undergo hyperinvolution and this leads to the formation of colloid goiter. These subjects are euthyroid (normal thyroid function). Thyroid function is preserved by the preferential production of excess of T3.

It is possible that repeated cycles of hyperplasia and hyperinvolution may lead to the formation of multinodular goiter later. Diffuse colloid goiters are common in younger subjects and are unusual above the age of 40 years. By the age of 35 to 40 years, the diffuse goiter becomes multinodular.

Treatment: Administration of thyroxine (up to 0.3 mg/day) brings about a favourable response in 60% of subjects. The gland shrinks within 3 months of starting treatment. Treatment has to be continued for 1-2 years or more. Complete regression of the goiter is rare. Abrupt withdrawal of the drug causes exacerbation.


Endemic Goitre

This is a very common public health problem all over the world, especially in Africa and India. Iodine deficiency manifests in various ways and goiter is the most easily recognized form.
This is a very common public health problem all over the world, especially in Africa and India. Iodine deficiency manifests in various ways and goiter is the most easily recognized form. | Source

Endemic Goitre

This is a very common public health problem all over the world, especially in Africa and India. Iodine deficiency manifests in various ways and goiter is the most easily recognized form. Endemic cretinism, which is also common, leads to severe morbidity in these zones. More than 9 million persons live in the endemic goiter belt in India. An area is termed endemic for goiter when 10% or more of the population is affected. Important among the well recognized goiter belts of the world are the high mountain regions of Andes, Alps and Himalayas, region of the great lakes of USA, and several pockets in Africa (Zaire). The broad belt covering the mountain ranges of Afghanistan to the sub-Himalayan regions of India, Pakistan, Nepal, Bangladesh and Burma extens up to Malaysian archipelago and Indonesian islands. Apart from these well recognized regions, many other states in India, such as Haryana, Rajasthan, Uttar Pradesh, Orissa, Madhya Pradesh, Tamil Nadu and Kerala also show wide areas of iodine deficiency. In these endemic belts, the daily iodine intake is generally less than 50 mg. The drinking water is very low in its iodine content.

Other dietary sources of iodine such as sea fish, milk and eggs may be absent in the diet.

Pathology: The thyroid gland is enlarged with hypertrophy and hyperplasia of the cells. The euthyroid state is maintained in many subjects because of the increased production of T3. The plasma inorganic iodide levels are low. The absolute iodine uptake by the thyroid is maintained normal by increasing the plasma clearance rate of iodide. PBI is also normal. Urinary iodide excretion is low. Plasma T4 is normal but T3 may be high. Correction of iodide deficiency leads to resolution of the goiter. Alternatively, the cells may undergo hyperinvolution. In this case, the acini become filled with colloid and diffuse colloid goiter may develop. With repeated episodes of iodine depletion and repletion, multinodular goiter may develop.

Preventive measures: Several strategies have been tried on a national and international basis for correcting widespread iodine deficiency.

Fortification of common salt with iodide (1 part to 100,000 parts) and distribution in endemic areas has been partially successful in many regions.

Injection of 3-4 ml of iodised oil containing 540 mg iodine per ml once in 2 years affords effective personal prophylaxis. Substitution of iodide promptly reduced the goiter rate ad incidence of cretinism in endemic areas. An adverse effect of iodine supplementation is the development of acute hyperthyroidism (Jod Basedow Phenomenon) in a few subjects.

Sporadic Goitre

Source

Sporadic Goitre

The etiology of sporadic goiter is not fully clear. The possible causes include increased iodine demand during pregnancy or puberty, presence of goitrogens in the diet and genetic factors. Exogenous goitrogens include common drugs, such as thiocarbamides (antithyroid drugs), chlorpropamide, PAS, iodine on a long-term basis, reserpine, phenylbutazone and lithium carbonate. Items of food like cabbage, turnips, soyabean flour, and cassava may act as goitrogens. Cabbage contains thiocyanates which inhibit iodine uptake. Cassave (tapioca) containes cyanogenic glycosides which are converted into thiocyanate.

Goitre may be the result of defective hormone synthesis. Such defects may involve pathways like oxidation, organification, coupling of iodine or proteolysis. The condition manifests as large goiters which show increased iodine uptake. Features of hypothyroidism or cretinism may be evident in some cases. Depending on the enzymopathy, monoiodotyrosines or di-iodotyrosines may be elevated in blood. In many cases, the goiter is familial.

© 2014 Funom Theophilus Makama

Comments

    0 of 8192 characters used
    Post Comment

    No comments yet.

    working

    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://hubpages.com/privacy-policy#gdpr

    Show Details
    Necessary
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
    Features
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Marketing
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Statistics
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)