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The Flab Jab - Vaccination Against Obesity

Updated on July 11, 2012

The Flab Jab - The Future of Weight Control


Straight Out of the Movies

The "flab jab" would seem to be the stuff of which sci fi movies are made, but could future generations really be vaccinated against obesity in the same way as we currently vaccinate against other illnesses such as polio, diphtheria and tetanus.

Well if recently released results of trials held are any indication, the answer would have to be that it could be a definite possibility!

Could this vaccination be signalling the death knell of the multi-billion dollar weight loss and diet industry.

More importantly could this vaccination be the magic bullet that can turn around the obesity health time bomb, that is ticking in many countries across the world.

How Does the "Flab Jab" Work

The vaccination works by introducing modified somatostatin to the body so that it is encouraged to produce antibodies to somatostatin.

Building an immunity to somatostatin, a peptide hormone, helps to treat obesity because somatostatin inhibits the action of two chemicals in the body, growth hormone (GH) and insulin-like growth factor (IGF-1), which act to increase metabolic rate thereby increasing the number of calories burned.

How Were the Trials Carried Out

The research was carried out using three groups of ten diet-induced obese male mice. Two groups received slightly differing variations of the vaccine, while the control group received injections of saline solution.

The mice in all three groups were fed a high fat diet for eight weeks before the study started and they continued with the same diet for the whole of the six week study.

The vaccination took place on day 1 with a booster being administered on day 22.

Could a Simple "Flab Jab" Prevent This Happening


This article provides details of research published in the Journal of Animal Science and Biotechnology on 9 July 2012.

What Were the Results of the Trials

Four days into the trial the mice vaccinated with the modified somatostatin showed a 10 per cent drop in body weight which was not seen in the control group.

The reduced body weight was maintained through the period of the study and test showed that both variations of the vaccine had caused the production of somatostatin antibodies without any changes of the growth hormones or insulin.

What Next

Well there is information which indicates that a similar type of study carried out using pigs showed that the vaccine was effective in much lower doses that given to the mice.

But there is a great deal more research needed and clinical trials to be carried out on other animals before testing can begin will real people. All of this means that we are likely to be very many years away from this treatment reaching the market, assuming of course that all runs smoothly along the way.


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    • Amber Allen profile imageAUTHOR

      Amber Allen 

      6 years ago

      Thank you Rastamermaid, Dale Hyde and jpcmc for taking the time and trouble to read and comment on my hub. Obesity is such a huge problem. My concern is that if this jab did prove successful in the short term but it had serious long term health effects the cure could be worse than the condition it is trying to cure.


    • jpcmc profile image

      JP Carlos 

      6 years ago from Quezon CIty, Phlippines

      Exercise and proper eating is the first choice. Many people with a weight problem can be solved with proper lifestyle.

    • Dale Hyde profile image

      Dale Hyde 

      6 years ago from Tropical Paradise on Planet X

      Most interesting. I had not heard of this particular vaccination. It would probably be a good thing if further testing reveals no terrible side-effects. Thanks for an informative hub. Voted up, interesting and useful.

    • Rastamermaid profile image


      6 years ago from Universe

      Nice hub,very informative,good info.

      I'll stay posted for updates.



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