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The Sinclair Method: a revolutionary treatment for alcohol abuse

Updated on June 11, 2012

Sobriety without abstinence

The Sinclair Method is a unique treatment for problem drinking. It does not rely on enforced abstinence maintained by willpower, 12-step programs, aversion therapy with Antabuse and/or behavioral therapy. It does not involve a period of detox and there are no withdrawal symptoms. The Sinclair Method is also not a method to achieve controlled drinking through willpower. It uses a drug called naltrexone, which is used to treat other forms of addiction. Naltrexone cancels out the patterns established in the brain of an alcoholic by an extended period of alcohol abuse. These patterns are responsible for the cravings that are experienced and provide positive reinforcement each time alcohol is consumed. When naltrexone is used, with time, the desire to drink excessively becomes extinguished. Some people who succeed with the Sinclair Method ultimately decide to become abstinent. Others continue to drink alcohol periodically, but remain within the generally accepted safe limits for drinking.

Conventional alcohol treatment programs and their results are described below. This is followed by an account of different approach taken by the Sinclair Method and the advantages this brings. Finally, possible reasons why the Sinclair Method has not become more widely accepted are discussed.

Pattern of conventional alcohol treatment programs

Mainstream alcohol dependency treatment takes the following course. The alcoholic is asked to stop drinking immediately and abruptly. This is the period of “drying-out” (detoxification), during which alcohol is eliminated from the body. Many people experience unpleasant and even dangerous withdrawal symptoms during the detox phase, which may last for up to two weeks. Patients frequently stay in detox centers during this first phase. They are monitored and, if necessary, are given barbiturates, benzodiazepines or both types of drugs together to help them through the process.

After this, the person is told to remain abstinent for the rest of his or her life. Cognitive behavioral interventions or other psychosocial support, such as the 12 step program of Alcoholics Anonymous is used to support abstinence. Medication is frequently prescribed as well.

The three main types of medication, which can be used to assist abstinence, either alone or in combination, are:

Disulfiram (Antabuse) is taken for its deterrent effect. Alcohol is metabolized to acetaldehyde. A liver enzyme called aldehyde dehydrogenase breaks down the acetaldehyde further so that it can be excreted from the body. Disulfiram works by inhibiting the activity of aldehyde dehydrogenase. As a result, high levels of acetaldehyde accumulate in the blood. The acetaldehyde dilates the blood vessels and acts on heart, which leads to a number of unpleasant symptoms. The person becomes flushed and nauseous, feels his heart race, experiences dizziness, headache, palpitations and shortness of breath. A severe reaction may include vomiting and even unconsciousness and can be life-threatening.

Acamprosate (Campral) is used to relieve withdrawal symptoms and craving. Alcohol increases the action of a neurotransmitter in the brain called GABA and decreases the effects of excitatory amino acids such as glutamate. The net result is a depressant effect. Over time, the body adapts by increasing the activity of the glutamate system and decreasing that of the GABA-ergic system. When alcohol is withdrawn, the depressant effect stops, but the neurons keep on being hyperexcitable. On its own, the brain needs many months to readapt. Acamprosate helps to restore the activity of these two systems to normal levels.

Naltrexone is used in the treatment of drug addiction as well as alcoholism. It blocks opioid receptors in the brain, but its mechanism of action has not yet been fully clarified. It is thought that naltrexone decreases the reward effect felt after consuming alcohol.

Results of conventional alcohol treatment programs

There is certainly no doubt that the strategies involved above can be successful in some cases. However, the level of success is fairly limited.

Success rates for the 12-step program of Alcoholics Anonymous are hotly disputed. Critics estimate that as few as 5% of all people starting with AA achieve long-term abstinence. What is evident from personal testimonies on the Internet is that while many are strong supporters, the structure of the organization does not appeal to all, with some considering it to resemble a cult.

The drastic effects provoked by drinking while on disulfiram result in a high drop-out rate. Some alcoholics, under pressure from medical professionals or families to take the medication, resort to elaborate measures of deception to avoid swallowing the tablets while feigning to do so.

Acamprosate and naltrexone produce a modest level of success when abstinence is used as the criterion of success.

A meta-analysis by Srisurapanont and Jarusuraisin comparing the results of 24 studies on a total of 2861 subjects showed that in the short-term, naltrexone gave a 36% decrease in the relapse rate. After 12 weeks, naltrexone was superior to placebo only in the time to the first drink and intensity of craving. Furthermore, 36% of subjects stopped taking the drug in the first 12 weeks. All subjects were also receiving some form of psychosocial support during the studies.

A meta-analysis by Rösner and colleagues compared the effect of acamprosate with that of naltrexone. The authors concluded that while acamprosate was better in preventing a lapse (having a first drink), naltrexone was better in preventing a lapse from turning into full relapse (resumption of the drinking habit).

Kiefer and colleagues found that the rate of success in maintaining abstinence was slightly increased in subjects who received combined therapy with acamprosate and naltrexone.

Roy Eskapa: The Cure for Alcoholism

The Cure for Alcoholism: Drink Your Way Sober Without Willpower, Abstinence or Discomfort
The Cure for Alcoholism: Drink Your Way Sober Without Willpower, Abstinence or Discomfort

A detailed description of the Sinclair method and how to apply it.


The Sinclair Method: how does it differ from conventional alcohol treatment programs?

The Sinclair Method is fully described in a book by Dr Roy Eskapa, The Cure for Alcoholism.

David Sinclair developed his method following observations that when rats with experimentally-induced alcoholism were given opioid antagonists together with alcohol, they showed a progressive decrease in alcohol consumption. Giving an opioid antagonist during enforced abstinence not only did not reduce subsequent drinking but tended to increase it.

Interview with David Sinclair - Part 1

He hypothesized that drinking alcohol at the same time as taking an opioid antagonist will block the reinforcement that a drinker gets from alcohol. This reinforcement is something that has been learned over a prolonged period of alcohol abuse (no one becomes addicted to alcohol after a single drink). Over time, both drinking and the craving for drink will become extinguished and the pattern of excess drinking will be unlearned.

The Sinclair method is based on the subject taking naltrexone only on days when he or she intends to drink. One tablet is taken approximately one hour before drinking. In this way, an alcoholic can be helped to regain sufficient control to continue drinking within safe limits, even if he or she does not choose to move to full abstinence.

Sinclair is currently claiming that the results of 76 studies have shown a 78% success rate over 3-4 months. One extended study gave a 50% success rate after 3 years. Success is defined as a subject reaching a level of controlled drinking within safe limits or choosing to progress to full abstinence.

Sinclair is adamant that continued success of the method is dependent on naltrexone being taken each time the subject wishes to drink, no matter how infrequently this might occur. Drinking without naltrexone would result in an even greater level of reinforcement than previously experienced and restore the previous pattern of alcohol abuse and dependence.

Interview with David Sinclair - Part 2

Advantages of the Sinclair Method

Drinking is not stopped abruptly. The gradual decrease in drinking that sets in as a result of the extinction process means that subjects do not experience withdrawal symptoms. Costly stays in detox centers are therefore avoided. In addition, there is no requirement for supportive treatment with barbiturates and benzodiazepines, which can themselves cause addiction.

Sinclair believes the method may possibly succeed without reliance on psychosocial interventions. Some practitioners still choose to use them, however the cost of rehab treatment may potentially also be avoided. The reason for this is that the method does not rely on forced conscious changes in behavior, but on pharmacologically-driven unlearning of behaviour at the same physiological level where the pattern of alcohol abuse was established.

Naltrexone is no longer under patent protection. Cheaper generic formulations are available. With time, many people find that they no longer with to drink daily. Since naltrexone is only taken on drinking days, this further reduces the cost of their medication.

Interview with David Sinclair - Part 3

The subject alone decides if and when to drink. No compulsion is exerted at any stage and abstinence is seen as a matter of free choice. Autonomy and dignity are therefore supported by the Sinclair method. People are finding it possible to drink socially in a controlled manner. One participant on an Internet forum describes his relief at being able to attend social functions without drawing attention to himself either by forced abstinence or by drinking to excess.

An article in The Times (UK) cites the experiences of two people on the program:

“Oh yes, I still enjoy good wine. I savour wine. But there's no craving.”

“With naltrexone, it's weird. You drink and you feel the effect of the alcohol but it doesn't have the magic.”

Interview with David Sinclair - Part 4

Why is the Sinclair Method not in widespread use?

Following Sinclair’s move to Finland, his method has found widespread use there among mainstream practitioners. Elsewhere, it has gained little acceptance. Paradoxically, its advantages may be among the factors contributing to its limited uptake.

Since naltrexone is no longer under patent and since it use gradually decreases over time, there is no major drug company that would find championing the Sinclair method particularly advantageous to its profits.

Elimination of the need for detox, and possibly also the need for rehab, is a threat to the highly profitable alcoholism industry.

The autonomy of people on the Sinclair method, and the fact they are left with a free choice when and how much to drink rather than compelled to full abstinence does not fit with the philosophy of Alcoholics Anonymous and other 12-step proponents.

Nevertheless, the success reported by Sinclair raises the question of why his method is not being investigated more widely. A quick review of alcoholism forums on the Internet showed that many, for whom mainstream methods have failed, are desperate to find a practitioner willing to let them try this controversial method. Where such help is not forthcoming, some people are deciding to go it alone. They are buying naltrexone on-line, despite the risks of self-medication and the further risks of purchasing from potentially dubious suppliers. They should be given the opportunity to try in the safest possible way a method that may help them to find freedom from the prison of alcoholism.

References and acknowledgements

M. Srisurapanont and N. Jarusuraisin
Naltrexone for the treatment of alcoholism: a meta-analysis of randomized controlled trials
International Journal of Neuropsychopharmacology Vol. 8, pp. 1–14, 2005 full text

S. Rösner et al
Acamprosate supports abstinence, Naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
Journal of Psychopharmacology, Vol. 22, No. 1, pp. 11-23, 2008 abstract

F. Kiefer et al
Comparing and Combining Naltrexone and Acamprosate in Relapse Prevention of Alcoholism : A Double-blind, Placebo-Controlled Study
Archives of General Psychiatry, Vol. 60, pp. 92-99, 2003 abstract

P. Wark
Naltrexone: can a pill cure alcoholism?
The Times, January 12, 2009

J. D. Sinclair
Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism
Alcohol and Alcoholism, Vol. 36, No. 1, pp. 2-10, 2001 full text

Illustrations by:

vipin09 on Deviant Art (prisoner)

yanivba on Flickr (whisky)


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    • WriteAngled profile imageAUTHOR


      6 years ago from Abertawe, Cymru

      Wish you all the best!

      There are a number of forums on the Net, the members of which include people using the Sinclair method. They do sometimes share the names of sympathetic doctors, who may be willing to help if a person't own doctor is not interested.

    • profile image


      6 years ago

      OK , I am going to try this. I drink 3 pints of Vodka each day ! Yeah pretty bad...My doctor would not order this prescription for me (not enough info from his colleges) so I ordered it thru Canada (very expensive) . I will let you know - I had it overnighted so should start June 21

    • WriteAngled profile imageAUTHOR


      6 years ago from Abertawe, Cymru

      Thank you Larry!

      I keep a fairly strict tally of average consumption. Living on my own I find it easy to work through a bottle of wine in an evening, especially if I am working late. If I do, then I do not allow myself any more alcohol for at least a week, which means I've kept to an average of just under a glass a day.

    • Larry Fields profile image

      Larry Fields 

      6 years ago from Northern California

      Hi WriteAngled,

      Fascinating hub! Voted up and shared.

      My alcohol tolerance has been all over the map. Several years ago, I enjoyed a glass of red wine with supper. Then it was two glasses, then half a bottle. My inner voice said:

      Hey, wait a minute! That's way out of the healthful range.

      These days, alcohol is not part of my daily routine. However I may have a drink on special occasions.

      I'm not an alcoholic, and I'm not on any kind of wagon. But I do consider myself to be at risk.

    • Hollie Thomas profile image

      Hollie Thomas 

      7 years ago from United Kingdom

      Hi WriteAngled,

      When I worked with heroin/crack users Naltrexone was sometimes (cost was always the issue) prescribed, with some success I might add. The only issue was that those users who lapsed (despite being warned of the dangers) would use on top of their treatment, and because of the lack of "effect" would use far more than their bodies could handle (resulting in OD's and sometimes death) But that's a completely different issue for those with alcohol problems. This sounds really positive.

      Subutex (a blocker and substitute) was also used fairly often, I wonder if that's now used for alcohol issues? I can see that both medications would be much safer for alcohol misusers than substance misusers. Progress!

    • WriteAngled profile imageAUTHOR


      7 years ago from Abertawe, Cymru

      I'm sorry, Moonwater, I really don't know. You need to contact a doctor who uses the Sinclair method with patients and who could give further guidance.

    • profile image


      7 years ago

      My husband took Naltrexone as advised and it worked great in a very short less than a month. He no longer had drinking binges every few days! He did not crave it, but would only have a little each time he took the medicine. This lasted over a year. Then he went on a vacation with a big..drinking..friend for 4 days. He refused to take Naltrexone with him saying he is fine now. Well..that drinking binge brought him back to where he was before. My question is, does anyone know if Naltrexone will help again? Would he now need a higer dose? It does not seem to be helping like it did before. HELP!!

    • profile image

      Bryan S. 

      7 years ago

      The 5% success rate attatched to A.A. is, as I see it, deceiving. The # of people court ordered or pressured to try A.A is great. The true success rate could be better related to those who truly want a solution and work the program as it is designed. In other words, working all the steps as they are laid out. This is not to say that I think AA is the only way to become sober. I am intrigued by the sinclair treatment and would consider it myself if AA was not improving my life beyond just not drinking. I feel for anyone battling alcohlism and addiction, wishing recovery to all who seek it. My fear is that those who want to continue drinking and think a pill is all they need to drink rationally may sell themselves short. I personally know someone who has just begun this treatment and hope it works for him. He is a great guy with a fatal disease.

    • profile image


      8 years ago

      It is a crime that so many alcoholics are suffering worldwide when this method could help them. As with everything in the US, it's all about money. Naltrexone is generic, and what would the multi-billion dollar rehab industry do?

    • WriteAngled profile imageAUTHOR


      8 years ago from Abertawe, Cymru

      Thank you DrRoy.

    • profile image


      8 years ago

      Thank you for presenting TSM so well.

    • Mighty Mom profile image

      Susan Reid 

      9 years ago from Where Left is Right, CA

      When I think of the MILLIONS of dollars spent each MONTH on detox and rehabs (the average person goes through the revolving doors at least 3x) that could be saved -- especially the taxpayer dollars -- I don't know whether to scream or pull out my gun. I have long felt that alcoholism is big business -- DUI "schools" are a cottage industry unto themselves.

      I do hope to be reading more about this alternative and seeing it offered in CA.

      I've had this conversation with many friends in AA. Those who are honest admit that if they could drink without the cravings (and all that goes with them -- ugh) they definitely would!

      Thanks for this excellent hub. MM

    • Dale Mazurek profile image

      Dale Mazurek 

      9 years ago from Canada

      Without this hub I never would have known about the Sinclair Method.

      One of the most interesting hubs I have read in a while.

      It definetly gets a spot on my blog

      Great work


    • WriteAngled profile imageAUTHOR


      9 years ago from Abertawe, Cymru

      Thank you, Pamela. I really hope this hub can contribute a little to spreading knowledge about this method. It deserves to be far better known.

    • Pamela99 profile image

      Pamela Oglesby 

      9 years ago from Sunny Florida

      This is a very interesting article and Nailtrexone sounds like a great drug for help with alcoholism. It sounds like this is helpful because you don't have the problems associated with abrupt withdrawal which are usually gone in a few days but the habit of dealing with life in a particular way persists for a longer period of time. My father was alcoholic but died sober after 35 years of sobriety. He never took antibuse or any drugs as they weren't available back then. He was in and out of AA a few times and then it was like he just got it. He had a great support group with many friends and for him it was the answer at a time in history when there were not other answers. Street drugs had not yet become popular which certainly complicates recovery for many people. I am glad to know there is a product available for a smoother transition from alcoholism into a more normal life. Great hub.

    • Lynda Gary profile image

      Lynda Gary 

      9 years ago

      Wow. This is literally the best hub I've read since I joined. Professional, accurate, extraordinarily well written and documented. I'm curious: Did HP flag this for anything? A similar hub of mine was flagged for being "overly promotional" due to my reference links. I had to remove them. (Maybe if I'd used your formatting?)

      I was drawn to this hub because of having so many clients who struggle with alcohol and drug addiction. Def going to bookmark this and research further. Thank you!

    • wyanjen profile image

      Jen King 

      9 years ago from Wyandotte Michigan

      Outstanding information. Thanks for this hub!

      Addressing alcoholism without abstinence... statistically, the Sinclair Method blows AA out of the water but I have a sense that there is even more to it.

      As a smoker who is trying to quit but doesn't want to, I'm finding that the switch to e-Cigs has been amazing. I don't have panicky pressure filled moments where I'm fighting against the "all or nothing" cold turkey method.

      I have to think that without forcing abstinence, this method must be attracting people who would otherwise not attempt to deal with alcoholism in the first place.

      AA's 95% flunk rate is a is a deterrent to people I know personally; they think that if the "best and only" cure for drinking problems is a program that doesn't help, that must mean there is no hope. :(

      Thanks again for this valuable hub. I will be referring folks to you!


    • Niteriter profile image


      9 years ago from Canada

      I set aside some time to digest the meaning of your word "discombobulated". It's delightful word to be sure and I will doubtless be on the lookout for opportunities to use it in my own work. Thank you for the gift.

      As a return gift to you, I offer a word I hope will relieve you of any guesswork concerning motives in whatever future encounters you may have with me: "farceur".

      Best wishes.

    • Niteriter profile image


      9 years ago from Canada

      After reading this Hub I am much encouraged. Surrounded as I am by oodles of evangelical Christians, I had been under tremendous pressure to dismantle my moonshine still.

      With this soul-stirring information from you, I'm now able to tell all the good folks trying to rescue me from the eternal flames that I've started to retreat from my bibulous ways. I'll be sure to add that I'm using the Sinclair Method. I figure it shouldn't take me more than... oh... 30 years?

      I have to run along now and pick up some new tubing for my still. This was a great Hub. Yes sir... a great Hub!

    • profile image


      9 years ago

      impressive hub. i applaud your meticulous research and lucid writing on such a bold topic. rating you UP.

    • Highvoltagewriter profile image

      William Benner 

      9 years ago from Savannah GA.

      Great hub well researched! I will read more of your hubs!Welcome to hubpages!

    • emohealer profile image

      Sioux Ramos 

      9 years ago from South Carolina

      Extremely informative! I found myself drawn to every word on the page, no speed reading here! The information you presented makes so much sense, there should be ways to utilize this treatment method everywhere. Truthfully though I must say I think it has less to do with money than it does with control and ego. The mainstream systems abstain from empowering choice, while Sinclair's method empowers with personal choice. The mainstream believes that given a choice we will all fail, so we must be dictated and forced to do what they deem appropriate, therefore giving themselves the big pat on the back on what a good job they are doing saving humanity. Thank You for sharing this information on choice as many have plenty to gain from it! Bravo,,,write on!

    • janiek13 profile image

      Mary Krenz 

      9 years ago from Florida's Space Coast

      Interesting hub. It makes a lot of sense. I believe that cocaine abusers could be helped by certain types of ssri's, due to the similar effect on the brain. You are right, Mr. Sinclair will find it difficult to find funding among the rich and useless.


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