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Top 5 Worst Drugs in the World

Updated on June 16, 2012

There are many drugs in the world. Some unheard of to people in certain regions of the world. Most people are blind to the fact that cigarettes are considered drugs and are very addictive, even though they are considered legal in the United States. Alcohol is also considered a drug, and is extremely addictive, but is also a legal substance around the world. This article is not gonna identify the most common and addictive substances that many people can get their hands on throughout a daily basis.

The following list comprises of the most dangerous drugs that can cause death via murders, suicides, and lost of free will. These addictions are so powerful that withdrawal symptoms can cause one's ultimate demise. All of the named products are in no particular order but they are the worst of the worst. Some are or were legal during some point in time.


Those who are using heroin are at the largest risk of having an overdose related death. When a person purchases heroin from a drug dealer on the streets, its impossible to tell the true purity of it. There are many accidental overdoses recorded every year because sometimes batches of pure heroin are released to the streets, which overwhelms the tolerance of regular users. While smoking or snorting it reduces the overdose risk compared to injecting it in your veins, it doesn't necessarily mean that it will prevent the inevitable results of this dangerous drug. To add insult to injury, it is extremely addictive.

Long term use may result in scarred or collapse veins. Bacterial infections are also associated with heroin use due to sharing syringes, which infect the blood vessels, heart valves, abscesses and other soft-tissue areas. Dangers also include liver and kidney diseases. Tuberculosis and pneumonia, miscarriages, premature birth, constipation, hemorrhoids, malnutrition, and weakened immune system can occur as well.

Bath Salts

Bath salts contain many dangerous chemicals that are known to result in psychotic episodes, murders, suicides, and deaths due to overdose on their own. When all of these chemicals are combined, it creates what is likely to be the most life-threatening drug in the world. People who use this are almost always likely to suffer a violent episode of psychosis, which has been reported on many occasions to lead the individual to commit murder/suicide.

The following chemicals are found in bath salts, which was legal at one point in time. Those ingredients are mephedrone, methylenedioxypyrovalerone (MDPV), and methylone.

Methylone is an entactogen/stimulant and is a relative to the cathinone, amphetamine, and phenethylamine classes. It was originally used as an antidepressant now is abused as a recreational drug, sometimes included in other substances like bath salts. Effects include anorexia, hyperthermia, hypertension, psychosis, mydriasis, and trismus. Sudden death is likely as well. The DEA banned it from use in bath salts and is individually banned in states including Florida, Louisiana, and Tennessee.

Mephedrone is another active ingredient once used in this synthetic drug. Dangers are similar to those of methylone and has resulted in casualties of its users.

MDPV is a psychoactive drug with stimulant properties. Effects of this is high blood pressure, digestive problems, pupil dilation, kidney pain, tinnitus, severe paranoia, suicidal thoughts and actions, respiratory failure, and seizures. More information can be found at the bath salts link above.

Angel's trumpet
Angel's trumpet


Scopolamine is a tropane alkaloid drug that is extracted from plants commonly in Columbia in the Solanaceae family of plants such as Angel's Trumpets and corkwood. When used for recreational and criminal purposes, this can be an extremely dangerous drug. If taken in large amounts, a person can die instantly of overdose. Although it can be a very dangerous drug, it also has some legitimate medical purposes in very little doses. An example of benefits include motion sickness, which is used in transdermal patches.

It is believed that this drug can make someone lose their free will, subject to control by others. In Columbia, people tell stories of being raped, beaten, and robbed with their consent when poisoned by this drug. They claim small amounts are blown into the face of victims and turn into mindless zombies. One in five emergency room admissions in Columbia are related to Scopolamine. It can also cause severe psychosis in individuals.

Methamphetamine (Crystal Meth)

Crystal Meth
Crystal Meth

Crystal meth, slang for methamphetamine, is a psycho-stimulant that falls in the phenethylamine and amphetamine classes of psychoactive drugs. In small doses it can increase alertness, concentration, and energy. In large amounts one may experience euphoria, enhanced self-esteem, and libido rises. When using it, meth activates what's known as the psychological reward system (PRS) which releases a large amount of dopamine in the brain, which can be very addictive. This drug is a lot worst than Crack Cocaine.

There are several dangerous side effects that can occur with crystal meth usage including convulsions, movement disorders, respiratory problems, anorexia, strokes, and mood swings. Another "physically visual" effect can be what some call "meth mouth," when the user has deterioration of the teeth and gums. If one decides not to use it, they may suffer post-withdrawal symdrome which can last for months or even a whole year. Withdrawal may lead to schizophrenia like psychosis and cardiovascular damage. Short term exposure to highly concentrated vapors of chemicals used in crystal meth can cause severe health problems and may result in a person dying.

Cigarette dipped in Phencyclidine (PCP)
Cigarette dipped in Phencyclidine (PCP)

PCP (Embalming Fluid)

PCP may affect one's behavior depending on the usage amount. Those who use a large amount may (more like will) be subjected to violent psychotic episodes, if they don't die of an overdose first. Low doses can result in numbness and intoxication, slurred speech, bloodshot eyes, and unbalance. Use of pcp may also result in convulsions. Changes in self image, loss of ego boundaries, paranoia, depersonalization, suicidal impulses, and aggressive actions are common in users. People who are under the influence of pcp will sometimes participate in self mutilation, feel less pain, and may seem "extremely strong" when having a psychotic episode.


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    • profile image

      Charles Dickins 

      4 years ago

      First off, LSD is one of the safest drugs out there, besides marijuana. Tobacco is the drug that kills more people than all of these drugs combined so get a grip! Secondly, angels trumpets arent illegal. That would be so stupid if they were. Jimson weed, another relative of the plant grows wild. Ive tripped on the seeds at a safe dose and that was enough to never wanna take them again. I will say heroin, crack cocaine, and krokodil are the worst drugs out there and if you have to do 5, add alcohol and bath salts though I know a ton of people who take bath salts and don't turn psycho like on the news. Ive done em and was completely fine, ur not supposed to snort a full gram or even a tenth of a gram of the stuff, that's comparable to drinking like 1000 alcoholic beverages.

    • profile image


      4 years ago

      it is interesting to have some angles' trumpet

    • profile image


      5 years ago

      Krokidil is the worst

    • kaiyan717 profile image


      6 years ago from West Virginia

      I used to grow and sell these plants at a nursery years ago, there is a beautiful double purple angel trumpet that has a pure white inside. Not too long after the summer of 06-07, the state of Mississippi had made them illegal because so many teens were dying from it. Deady yes, but it is a beautiful plant. Surprised to see so much use in Columbia, interesting.

    • bethperry profile image

      Beth Perry 

      6 years ago from Tennesee

      Interesting and useful, though I'm surprised not to see LSD on the list.


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