- Mental Health
Treatment of cancer with Ibuprofen, Aspirin, and Cyclohexi
A clinical study conducted by the London Metropolitan University, United Kingdom established that ibuprofen, aspirin and cycloheximide had the ability to reduce the risk of contracting cancer. The authors went on to note that these types of medications reduced the risk of contacting ovarian cancer by 45%, oesophageal cancer by 75% and stomach cancer by 62%. The study went on to confirm that the use of cycloheximide, aspirin, and ibuprofen was quite beneficial in the case of mismatch repair genes particularly when employed in prevention or treatment of the risks related with cancer. The efficiency of Ibuprofen was derived from the fact that it harbored a high amount of anti-cancer effects which were more effective when compared with aspirin and cycloheximide more especially against lung and breast cancer.
The report by the London Metropolitan University was found to have been backed by various other studies such as those of Aggarwal et al (2006), which established that the use of CHM, aspirin and ibuprofen were of great essence in reducing the mortality rates for risks associated with cancer by almost 22%. According to the authors, aspirin and ibuprofen constitute chemical compounds that work in suppressing cancerous cells that could be found in the body. On his part, Simmons (2004), explains that ibuprofen and aspirin work in suppressing cancer in different stages. They suppress the activities of two enzymes COX-2, COX-1 as a means of responding to the body inflammation. On the other hand, cyloheximide treats cancer by inhibiting protein synthesis, thus reducing the cytoxicity which is generated by the nitrogen mustard, arabinofuranosylcytosine or 1-B-D X-radiation in cells which do not have a problem such as the cells of the bone marrow or intestines
A 2013 study by the Bath University department of Pharmacology and Pharmacy noted that there were a possibility for ibuprofen which is an anti-inflammatory drug to stop specific cancers from developing. Evidence generated from this study indicated that long term users of Ibuprofen are better protected from such type of cancers as colon cancer, prostate cancer among others. Ibuprofen differs from other form of drugs in the sense that it exists in two forms, S- and R-. However, the R-form is inactive while the S-form has anti-inflammatory features. Nonetheless, the body is able to convert the R-form of ibuprofen into the S-ibuprofen through a chiral inversion process, which is scientifically believed to have benefits of suppressing cancer. This owes to the fact that the enzyme which is involved in the chiral inversion and which is identified as alpha-methylacyl-CoA racemase (AMACR), raises the level of some colon cancers, prostate cancers and other types of cancers. The study hypothesizes that how the processing of the drug by the body reduces the normal operations of the enzyme subsequently stopping cancer from developing (Lloyd et al, 2013).
An analysis undertaken by the University Of Cardiff School Of Medicine on the effects of aspirin on cancer treatment established that the medication had cancer fighting properties despite the inherent limitation and side effects. This study which was mainly qualitative analyzed 47 high quality journals related to aspirin and prostate cander, bowel cancer, and breast cancer. Among these studies, there were those whereby the authors followed the participants for more than five years, while others compared the efficacy of aspirin with placebo treatments. Furthermore, there were those which compared the use of aspirin with treatment of cancer. The general finding from this study was that aspirin had a potential of reducing cancer deaths alongside the spread of many types of cancers. Nonetheless, the researchers observed a need for a more in-depth research to establish the effectiveness of faspirin with certain types of cancers or tumors related to particular genetic markers.
Sanchez et al, (1997) on their part found out that Cyclohexi worked by preventing Apoptosi which was induced by by TGF-Induced by the principal culture. Further, cycloheximide also inhibits the mechanisms which activate the production of ROS in fetal hepatocyte in the principal culture. This capability helps in inhibiting the protein synthesis in the body thus propagating the death of cells that could be considered as cancerous.