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Which is Better for Weight Loss and MS Fatigue Prozac or Gilenya?

Updated on April 20, 2012

I have been taking Gilenya for over six months now. It is an important milestone for me because six months is usually how long it takes prescription medications to begin to lose their effectiveness with my MS symptoms. Gilenya is still working for me and I am still noticing improvements with my fatigue level. I am leaning towards believing that this small oral medication has just begun to work.

I am having less nerve pain in my right leg. Although I have not read any testimonials stating nerve pain is known to decrease while on Gilenya in my case it is actually occurring.

I stopped taking Prozac about a month ago. I decided to slowly wean myself off the drug to see what would happen. Recently I had a hectic schedule to keep, one that called for more energy than I was capable of producing on my own. I took the Prozac but noticed no real benefit. The Gilenya provided the same amount of power only without the hyper feeling I get from Prozac. That is when I made up my mind that I could continue weaning myself off the Prozac. My new neurologist said he was happy that I didn't feel I needed Prozac as it testified to Gilenya's usefulness.

Weight Loss: Prozac vs. Gilenya

I lost weight while on Prozac it made me feel energetic which made me anxious to do things once more. It reminded me of taking Solu-Medrol without the terrible crash. I was not as hyped up on Prozac but I definitely wanted to participate in more physical activities. That extra exertion enabled me to lose weight.

Gilenya has also given me energy although I would say the energy source feels different. I often complained to my family that MS fatigue made me feel as if I were always fighting a cold or the flu. I can compare it to having an allergic reaction to mold.

It was clear my body was working hard to contain something, but I could never figure out what it was. Now that I have taken Gilenya my body no longer feels it is waging war trying to keep out germs or fighting with my own white blood cells. The result is that I am not as worn out.

I am anxious to see what happens after a year has passed. Will I be even stronger? That would be more than I hoped for when I first started Gilenya. My weight is slowly going down as I take on activities for longer periods of time.

Comparing a Pill to a Needle

As a disease modifying drug (DMDs) Gilenya is easy to administer. Some water and down it slides. Compare that to an injectable drug and Gilenya comes out the winner every time. That is not to say that there aren't side effects to this oral medication. I am still suffering from eye-sight changes that make me uncomfortable driving. I have to wait until my ophthalmologist examines my eyes to identify the source of my problem.

Being more prone to infections in general is a concern I didn't have when I injected Copaxone once a day. I don't miss those injection-site reactions however. Hardened nodules right under my skin were painful. The stinging that occurred during and after the injections is another side effect I am glad to say good-bye to.

Everything considered so far, it seems like it is a case of six-of-one and half-a-dozen of another. I prefer the pill's downside to the Copaxone's downside. It is something everyone dealing with MS has to personally decide.

Gilenya is Best for MS Fatigue and Weight Loss

I had my first examination with my new family physician. He was not thrilled with my blood pressure which was high because I stopped the medications. He wrote me new prescriptions and adjusted the one blood pressure pill that was causing a side effect I could know longer tolerate.

I have to see him in a month so that he can take my blood pressure again to make sure it has lowered. I will be able to check my weight again which I hope shows another couple of pounds have vanished.

So in conclusion, I have found that Gilenya gives me as much if not more energy than Provigil, best of all I do not have to increase the dosage. One .5 Gilenya capsule is all I need. Provigil needs to be increased in order to get the same benefit and it is a stimulant. Gilenya works on a totally different level and to my knowledge is not addictive in any way.

Losing weight might be a benefit that others do not experience. I don't know why it has helped me shed pounds, I am just glad it has!


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    • JanTutor profile image

      Jan Thompson 

      6 years ago from London, England

      A really useful hub. Because my condition is fairly rare there are no dedicated drugs - instead I'm treated with many of the drugs MS suffers receive. I hadn't heard about either of these before but will research further. As usual a worthwhile hub from a considerate hubber.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      6 years ago from Delaware

      Paradise7, you always make me feel special and I truly thank you for building me up and reading about my experiences. Thank you very much my friend!

      Dar/Jen :-)

    • Paradise7 profile image


      6 years ago from Upstate New York

      Good for you, Jen. I can't say how pleased I am with your new meds. I know everyone is different and reacts differently to medications but I'm very sure people with MS will find this article VERY helpful.


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