I take Tahitian Noni Juice at a level of 30 mls/2 x day (1 tablespoon 2xday) as the phytoceuticals in the juice look after what is called the endocrine cascade. That is, the effect starts at the pineal gland, then down to the pituitary, the thyroid, the thymus, the pancreas, the adrenals, the sex glands and so forth. I have been drinking it for 11 years and have Hashimoto's Disease (a form of hypothyroid) and take thyroxine T3/T4. I have found that my levels of thyroxine medication remained the same over a long period of time.My friend however,who has the same condition wouldn't drink the Tahitian Noni Juice and had to have her levels of medication increased substantially over that period. I felt that the juice was the difference between us. It works for lots of other things too. If you want to know more then go to my blog http://fibromyalgiaremedies.blogspot.com and sign up for my free ebook which will give you info about Tahitian Noni Juice. Hope this helps as it has helped me.