I'm not sure I accept the premise of a clear divide between "artificial" and "genuine."
For example, someone might be miserable because of a hormonal imbalance--that is, because of chemicals circulating in their bloodstream. Does it really make a significant difference that the source of the chemicals lies within the body rather than in a pharmaceutical company plant?
How about someone whose misery is due to their acceptance of an erroneous idea (say, "I am fated to be miserable due to the curse of a Gypsy fortuneteller?")
On the other side of the question, if someone has success in treating their depression with medicinal support, why pillory that choice as "artificial?" That person may be highly authentic and honest in facing their own life, and the world around them. Isn't that the important thing?