Good list of side effects by Mezo in his hub. I would add a few. As an occupational therapist working with hand/upper extremity and other orthopedic surgeons, my experience has been primarily with steroid injections for various musculoskeletal problems such as shoulder pain, elbow pain, trigger finger etc. Some people experience bleaching of the skin around the injection site which may not resolve. I have had African American women clients who were very distressed about this. I have known ortho docs who will do cortisone injections on diabetic clients only as a last resort. It destabilizes the blood sugar, and not just for a day or 2. Discuss injections with your internal med or family doc before considering cortizone injections.