Absolutely. I agree with FloraBeenRobison on SAD. Also, others made good points. Here is something that affects me. I live in Escondido CA, 15 miles from the coast. It is generally 10+ degrees hotter and drier. But, fall & spring coastal air moves in during the evening staying until mid-morning and my sinuses go crazy then accompanied with headaches.
When winter comes I like it, except for the darkness. It isn't the weather change that is difficult it is the lack of sunlight. My circadian rhythm goes bonkers. I dislike time changes because of this.