Does anyone have article about HbsAg & HbsAB negative and HbcAb positive?
During acute infection with hepatits B the B antigen is the first to rise (obviously as it is the infectious particle), and then the earliest antibody to form is the acute phase hepatitis B core antibody. This occurs at approximately 4-6 weeks and remains elevated indefinitely.
Next is the acute phase antibody (Ig-M) HBs-aby which rises then begins to drop in phase with the surface antigen.
There exists a window between 20-24 weeks post infection where screening tests will detect core antibody only as the surface antibdy (Ig-M) and surface antigen are declining and the chronic (Ig-G) antibody to the surface particle is not yet at detectable levels. Hence, HBs-ag and HBs-aby negative and HBc-aby positive.
If you request the acute and chronic phase antibodies to the surface particle it will likely be detected, but a simple screening test may miss it.
I hope this is helpful.
Dear Tiimarc,
Thank you for your help, but some people said that it is false positive of HBc. how do you think? It should be one of hep B is positive or the client is silent chronic Hep carrier that why the test can not detect for HBs Ag?
Respectful
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