Yes, I can. I know because I have. I've done it voluntarily by going on meditation retreat for 8 days. I've done it without having a choice by living through illness and high fever. And I mean giving up *all* of my favorite things. It is harder to give up just some of them, which I'm doing right now. For health and financial reasons, I'm giving up some things I like right in the middle of an ordinary, busy life. That is hardest of all, but I can do it.
And the value is great. We learn unconditional happiness - happiness that does not arise from having anything at all, but from being truly who we are, and giving what we have to give.