The first true bristled toothbrush originated in China at around 1600 AD. At around 1780, the first toothbrush was made by William Addis of Clerkenald, England. Addis, and later, his descendants, manufactured the finest English brushes, where the handles were carved out of the bone of cattle and the heads of the natural bristles were placed in the bored holes made in the bone and kept in place by thin wire. The natural bristles were obtained from the necks and shoulders of swine, especially from pigs living in colder climates like Siberia and China.
By the early 1800s the bristled brushes were in general use in Europe and Japan. In 1857, H. N. Wadsworth was credited as the first American to receive a toothbrush patent as America entered the growing toothbrush market. In 1844, the first toothbrush was manufactured by hand and patented as a 3-row brush of serrated bristles with larger tufts by Dr. Meyer L. Rhein.