I have written an Article on this particular subject. http://artist101.hubpages.com/hub/menapause-the-mi... It can have many physical causes, from meno, to poor health, to nutrition. Many times it isn't life circumstances that cause depression, there are many physical causes that can predispose you to this condition. Much like diabetes, or any other illness. Stress, can also be a contributing factor. Wether it is a current or past stress, it is a factor to consider. B complex vitamins help us to cope with life stresses, we require them daily. Either in our diet, or as a supplement. The more stress, the more b vitamins we require. Depression may be your body bottoming out, because it has depleted its store of nutrients. Your body is a wonderful, miraculous machine, that requires the fuel to maintain its health and well being. If you do not give it the required nutrients it cannot perform. Prayer, sunshine and fresh air are also helpful. I hope this helps.