It depends on what the dream job requires ... In my own case my dream "job" is getting the opportunity to write inspirational books that can change people's life.
This would mean coming out of my comfort zone, and doing a lot of things differently. It might mean giving up my positions as executive member of the PTA, community, and church organizations.
Things that I certainly would not give up are the nurturing relationships that I have especially with family members, my church family, and most of all my continuing fellowship with God.