There is no one best answer. It's like asking which is better... eating oranges or eating apples, or whether Hyundai is better than Mazda. It all depends on the individual... whether he is career-centered or family-centered.
When work affects health and family, then you know you have cross the limit. Some spouses, however, are more supportive of their husband than others. But when it comes to health, there's no compromise.