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Gout and Uric Acid

Updated on October 6, 2014
Gout attacks can be painful and often debilitating for 3 to 7 days.
Gout attacks can be painful and often debilitating for 3 to 7 days. | Source
Left foot before using PURIXA
Left foot before using PURIXA | Source
Left foot after using  4 bottles of PURXIA
Left foot after using 4 bottles of PURXIA | Source
Right Foot after 4 bottles of PURIXA.  User reports that the tophi on this foot was the same as the left foot before starting PURIXA
Right Foot after 4 bottles of PURIXA. User reports that the tophi on this foot was the same as the left foot before starting PURIXA | Source
Right hand before PURIXA
Right hand before PURIXA | Source
Right hand after 4 bottles of PURIXA.  Uric acid dropped from 10.9 to 7.4 and included life style changes in addition to taking PURIXA.
Right hand after 4 bottles of PURIXA. Uric acid dropped from 10.9 to 7.4 and included life style changes in addition to taking PURIXA. | Source

Get Your Uric Acid Levels Measured, Now!

If you were a diabetic or had high cholesterol you would get regular blood tests to see if your cholesterol or blood sugar is below the target level.

Well, hyperuricemia, the medical term for high uric acid (UA) levels, is no different.

If you have gout or uric acid kidney stones, there are medical guidelines that recommend you keep your UA level below a specific target. This is because you are much less likely to suffer from gout attacks if your uric acid can be kept below these targets.

To help prevent gout attacks, physicians recommend that sUA (serum uric acid) be lowered and maintained to a target of less than 6 mg/dL. This is a simple blood test and can be done in conjunction with other route blood work in your annual physical or other occasions when your blood needs to be tested or monitored.

During a gout flare, UA levels can be normal because the uric acid is deposited and somewhat sationary as urate crystals in the joints, and the level in the bloodstream is reduced. This means that you will need to wait a few weeks after an attack has completely gone before having your sUA measured.

A raised UA levels in your blood does not completely prove that an attack of joint pain was gout. Most people with slightly raised blood UA levels do not develop gout. However, the higher the level, the more likely it is that gout will develop at some point in your life.

Remember, keeping your UA level below target levels will help to stop gout attacks in the long term.

It is not only gout that is brought on by high uric acid levels. High UA is not a medical condition in itself but it is associated with several diseases such as gout, Lesch Nyhan syndrome, cardiovascular diseases, diabetes, metabolic syndrome, and kidney stone formation.

In managing UA levels, it is important to avoid purine-rich food and large amounts of foods with even moderate concentration of purine. Beer, red meat and seafood rank high on the list of no-no's. A diet low in purine content (low-fat dairy products, fresh fruit, fresh vegetables, nuts and grains) can play an important role in managing these levels because purine can increase the amount of uric acid in the body and may trigger a gout attack.

It is also advisable to reduce the amount of fructose in your diet, an ingredient found in sugar-sweetened soft drinks and other processed foods. Foods heavy in fructose are also commonly cited for their role in contributing to the obesity epidemic.

However, if your diet and lifestyle changes alone are still not achieving proper UA levels, perhaps a dietary supplement like PURIXA can help.

Diet plays an important role in the production of purine and uric acid production.  Blocking uric acid production or promoting its excretion is the main objective of gout medications and natural supplements like Purixa.
Diet plays an important role in the production of purine and uric acid production. Blocking uric acid production or promoting its excretion is the main objective of gout medications and natural supplements like Purixa. | Source

Water Can Be a Gout Sufferer's Best Friend

Our blood contains a certain percentage of uric acid at any one time. This uric acid is usually filtered from the bloodstream by the kidneys then it is eliminated from our bodies through urine. That’s when very thing works normally.

The problem begins when there is a buildup of excessive amounts of uric acid in your system (either in blood or kidneys) or the rate at which it is being eliminated through urine is too little. The condition is known as hyperuricemia (the medical term for high uric acid levels in the blood).

The increase of UA in your system will encourage the formation of tiny uric acid crystals. These crystals usually start to accumulate mainly around joints and eventually cause a reaction with our immune system when the crystals precipitate and release from the joint. This reaction with the immune system triggers sudden attacks of pain and inflammation at the affected area, usually in the toes or fingers.

With patients at risk of developing gout, certain conditions /events can cause acute attacks of gout due to the buildup of uric acid. These conditions include dehydration, excessive eating of food high in purines and fructose as well as heavy alcohol intake, particularly beer and grain alcohol.

There are several natural or homeopathic ways to deal with gout but we’ll just focus on the role of hydration in this article.

When you don't drink enough water, your body gets dehydrated. Dehydration may lead to improper kidney functioning. When kidneys do not function properly it might lead to formation of kidney stones, kidney infection and cause uric acid build-up.

Dehydration does not result just from lack of drinking enough water. Your body can get dehydrated if you consume drinks like coffee, alcohol or carbonated drinks. So for gout prevention and treatment, the first step you need to take is to reduce the intake of these drinks and increase the consumption of water. Sometimes it can be hard to motivate yourself to drink a lot of water during the day. In such cases you can drink fruit or vegetable juices. But it is best to stay with water as much as possible.

Often gout sufferers can tell when an attack may occur. In such instances it’s recommended that you drink 8 oz of water, six to eight times a day.

This helps the kidneys promote excretion of uric acid build up. Ultimately, this may help in reducing the frequency of gout attacks or at least making them less severe.

Body Building, Gout and Casein…What’s the Connection?

For as long as body builders have been…well building bodies, they knew the value of the dairy-based protein, Casein. Casein makes up about 80% of the protein in cow’s milk. It contains many of the necessary amino acids for muscle formation. Today, Casein is taken in significant quantity by body builders and fitness gurus as part of a daily regimen. Their results cannot be disputed and the safety risks are extremely low. So, good for body builders…what does that have to do with gout and high uric acid levels?

Well as it turns out, Casein, a no-purine, protein has a dual action of both blocking the production of uric acid as well as the attribute to promote its excretion. This sounds like a gout sufferer’s dream…a supplement that attacks uric acid from two sides. OK, curb your enthusiasm! It’s not the end-all, be-all to UA reduction, but it is a great start to achieving healthy uric acid levels. In fact there were two large studies done to prove Casein’s wonderful uric acid busting abilities.

In 1991, "The American Journal of Clinical Nutrition" published one of the most comprehensive studies on the subject. It found that uric acid levels in the blood significantly decreased three hours after the ingestion of lactalbumin, a component of casein protein. This is due to the fact that dairy has a "uricosuric effect." In other words, it causes the excretion of uric acid from the body.

A more recent study in a 2005 issue of "Rheumatology and Arthritis” (Choi, et al), found that dairy products, specifically milk on a daily basis, reduce the risk of gout in men, who are at the greatest risk. The study included 14,800 subjects.

See the figure below to understand the effects of Casein and other uricosuric and xanthine oxidase inhibitors (XOI’s decrease uric acid production by interfering with xanthine oxidase).

PURIXA's Dual Action

Xanthine oxidase inhibitors decrease uric acid production by interfering with xanthine oxidase while the uricosurics induce uric acid excretion by reducing the reabsorption of uric acid once the kidneys filter it out of the blood.
Xanthine oxidase inhibitors decrease uric acid production by interfering with xanthine oxidase while the uricosurics induce uric acid excretion by reducing the reabsorption of uric acid once the kidneys filter it out of the blood. | Source

New findings of gout and kidney disease among US Veterans

A new study was released in May 2013 in abstract by Stanford University, Stanford, California that showed male veterans with gout and uric acid levels greater than 7 mg/dl had an increased risk of kidney disease. Normal levels are considered to be “6.8”. The study attempted to look at the relationship between uric acid levels and the risk of kidney disease among veterans with gout and tophi.

The study followed service personnel for an average of six and half years and found a direct correlation between higher risks of kidney disease and gout. The men in the study had a high prevalence of other co-morbidities like hypertension, hyperlipidemia and diabetes.

The full study is expected to be released in the July, 2013 issue of Journal of Rheumatology, but the bottom line is that with high uric acid levels and the signs and symptoms of gout there is a good chance of kidney disease occurring.

Also earlier this year in the Oxford Journals (February, 2013) another study of US veterans with gout and high uric acid levels showed a direct association between hyperuricemia and the excess risk for developing diabetes. The study revealed that approximately 1 in 11 new cases of diabetes were statistically attributed to hyperuricemia. That study followed 1923 patients for over 6 years. The risk of diabetes was dramatically increased when uric acid levels were greater than 9 mg/dl.

Just a little background to these studies before we ridiculously assume that serving in the armed forces will causes gout. The prevalence of gout in the general US population is about 1.4% to 2%. The Department of Veterans Affairs is the largest health care delivery system in the US providing care to 5.2 million veterans. Although no solid statistics or studies are known at this time regarding gout prevalence among US veterans, gout is estimated to be at least twice as common in veterans as in the general population. Why? Veterans are older, more likely to be male, and have greater prevalence of other co-morbidities like hypertension and diabetes. So there is a high concentration of hyperuricemic patients in the VA just by the group’s natural selection. Researches who study the effects of high uric acid are more likely to find the VA a good testing ground with application to the general population.

The main take away from these recent US veteran studies is hyperuricemia can be linked to diseases other than gout. Gout and its signs and symptoms like gout attacks, tender and swollen joints and tophi on the feet, hands, elbows and ears are just the result of observable effects of high uric acid. But as the acid builds and “pools” in the body, accumulating over long periods of time, perhaps decades in the form of urate crystals or kidney stones, other organs like the heart and liver can also become reservoirs for the urate material.

On a personal note, my uncle Howard is a war veteran, 85 years old and has always led a “clean” and good lifestyle; never a drinker or a smoker, likes a steak on occasion but certainly not a “meat and potatoes guy”, does not like seafood or shellfish and exercises regularly. You know what? He has gout. So sometimes the stereotype “gout guy” does not fit the profile.

Please, get your uric acid measure on a regular basis and know your UA number!

What’s the Connection between Temperatures and Gout Attacks?

Cold feet from a day spent out in the snow, followed by an attack of gout the next morning is an example of a commonly reported trigger of acute gout. In cooler temperatures urate crystals form more easily. For that same reason, tophi (deposit of monosodium urate crystals in people with longstanding high levels of uric acid in the blood) form in the feet, hands, knees, elbows and even helix of the ear (upper rim of outer ear). In these extremities, body temperature tends to be a bit lower. This aids in the development of tophus.

But to fully understand this we first need to understand a little science. Gout is a true crystal deposition disease in which all clinical signs are considered to be directly attributable to the presence of monosodium urate (MSU) crystals. At normal body temperatures (98.6oF / 37oC) urate crystals form when uric acid approaches and exceeds urate acid levels of 6.8mg/dL. At times then body extremities go down to 95oF /35oC it actually takes less urate acid to form crystals. Because uric acid has limited solubility in bodily fluids, monosodium urate crystal formation occurs. These crystals and the while blood cells that attack the MSU crystals form the tophi.

Reduced solubility of urate at lower temperatures has therefore been suggested to account for the occurrence of gout at cooler distal joints such as the foot-ankle complex.

Thus, one aim of gout attack prevention is to keep the hands and feet warm. But remember, it all starts with keeping your blood uric acid levels in check through diet, lifestyle changes and medications. If you are looking for a natural way to support healthy uric acid levels, PURIXA can help.

This is a terrific video. The holistic approach emphasized in Dr Choi's talk is extremely important.

Gout Factoid #1 Casein protein can reduce the risk of gout

Gout Factoid #2 Uric acid can form kidney stones

Gout Factoid #3: Fructose can cause gout

Gout Factoid #4: American College of Rheumatology guidelines for treating gout

Gout Factoid #5 - Measuring Uric Acid levels. High Uric Acid Causes Gout and Kidney Stones

See What Folks are Saying about PURIXA™

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    • profile image

      Tizawiza77 3 years ago

      Greetings all gout sufferers,

      I wanted to post an update about Purixa. So far this product is helping me so much. I started on 4/5 and started on one time a day for about a week. Wish that I had the date logged when I upped it up to twice a day, but I was busy and didn’t think about it. I’m going to have to get used to keeping a log of what I’m doing.

      But after about a week, I then started twice a day, and on Friday of last week, I upped it to three times a day. I had started feeling even better on twice a day, and then I considered my weight and thought, hey, I’ll do it three times per day. That was the charm for me. I was feeling much better on twice, but three is working good for me right now. I’m no longer aching at nighttime. Before I started on more of the product, I was aching at night like I had the flu, although I didn’t have the flu. It was this gout stuff. And some crystals were probably breaking up. I’m convinced 100 percent that the Purixa is a must for anyone if they are not allergic to milk. I have mixed it in nonfat milk, and it’s good. I’ve mixed it in my tart cherry juice concentrate, and it’s good. Mostly I just mix it in my water.

      Here’s a problem that I’m having, and it’s not with the Purixa. We had bought an EasyTouch UA monitor. Last Friday I had tried in the morning to do my UA reading, but it gave me a 14. I knew that was way too high because I was feeling so good. Then waiting five minutes, stuck in a new test strip, and it says 3.3. So we have some troubleshooting to do with it and just haven’t had the time to figure out what’s going on yet.

      Anyway, another thing about Purixa is this, and I’m so sure it has helped me with this. I’m now exercising. I haven’t been able to walk any distance for years. I think it was in 2007 or 2008 that I hurt my hip when I fell. If I’d walk even five minutes, it would stiffen up and just kill me. Now I can walk about 15 through 20 minutes and no problem. Then after our walk, I come in and work out on my elliptical for another five minutes and do a five-minute cooldown.

      One more thing if you guys should try this product. I notice only one strange comment at Amazon where someone said that theirs didn’t come with a scoop. Well, consider that when this product is mailed, the scoop may be at the bottom of the container. I knew that would probably happen, so I stuck a spoon in it and found my scoop. It’s just going to get jiggled around in the mailing process.

      Besides the Pruixa, I’m drinking my water, about four cups or a little more of nonfat milk per day, my cherry juice and cutting out most meat. I do occasionally eat a little bit of chicken. Sometimes I have a cup of green tea. Then I have two cups of coffee in the morning. I plan on giving blood as soon as I can find out the info that I need to know.

      Now if I can just get my monitor to work.

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      Gregory 3 years ago

      I am Gregory the chiropractor who started to use your product due to a gout attack in June of 2012. My original # after my attack was 7.8. I then began to modify my diet (less carbs, less processed red meat, increase water intake, etc..) and decreased my level to 7.4. After trying another product, I searched more and cam upon Purixa. I can't say why I switched but I did. I'm happy to say my latest blood work shows that the uric acid levels have dropped from 7.4 in October/November to 6.4 when taken last week.

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      Barbara Cisneros 3 years ago

      I have had gout flare ups but with a low uric acid level so I don't know why I have gout at all. Anyway in doing as much research as I could since my doctor only gave me pills that didn't completely take away the gout symptoms, I came across Purixa and my gout symptoms are less. I take it at night before I go to bed and can now sleep through the night whereas before my feet would feel like they were on fire. After reading the above comments I might try taking it morning and night to see if that is even better. My diet has always been low purine because I eat very little meat or shellfish. I think my gout stems from being arthritic to begin with. Arthritis runs rampant in my family. I have also passed my Purixa on to a tenant and she was very grateful.

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      Bob from Lebanon, CT 3 years ago

      I have been using Purixa three times a day in 1 % low fat milk for a year and a half and it has helped me. My bi-monthly medium attacks ( unable to walk for a day) and once yearly big attack (unable to walk for 5 to 9 days have stopped so far! I still have some minor pain in my ankles and feet and occasionally in my thumb once in a while but I think that could be due to residual crystals dissolving and getting back into my blood for a while. I have also reduced read meat to a once or twice a month. I don't drink hardly ever and no shellfish. I couldn't take Allopurinol because of a bad rash.

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      Bob Mcdaniel 3 years ago

      First off I do not normally endorse any product I use take.

      Why we all have different genes so what is great for me might not be for someone else. The most important thing I have learned about gout during my research and talking to others who suffer from gout is that everyone is different.

      I just though I would let you know how Purixa is working for me and my (RCG) Refractory Chronic Gout. I have the presence of tophi in my right thumb and my left toe next to the big toe both tophus developments are coming out of the outer skin. I had surgery on my right foot (same toe) 2 years ago to have it removed it is now coming back into that toe again and all places are swollen and very sore.

      With all of this I must say am probably the perfect person to try your Purixa product as of my last Doctor Appointment in July 20013 my uric acid levels were at 10.9 and tophi coming out thru the skin was a big problem and not getting any better as described above.

      I refuse to take Aliopurinol or Uloric because of there potentially dangerous side affects some life threatening. I was looking for an out of the ordinary cures that give one extraordinary healing.

      My reason being I only have one Kidney that works at 30 % so I can not afford to kill this kidney with either of these drugs plus all of the other bad things that they can do to ones body. I have always drank 6-8 . . .8 oz glasses of water a day for my kidney. I have made other dietary changes; I have cut out meat, and drink one glass of green tea with dinner, and avoiding risk factors as I see them trying to halt the progression of my gout and preventing potential joint damage.

      I have been seeking new alternatives other then Allopurinol and Uloric that cost much more then Allopurinol that are the standard medicines for gout. And both need higher doses to work properly/ if they work at all.

      I have been looking at out of the ordinary cures a natural approach to treatment of gout and my tophi. And think it will do more then just mask the systems. I know it can not be cured completely but one can certainly control it.

      After spending many hours looking over your web site and all of the information and my July Doctors appointment talking to her about trying Purixa I ordered a one month supply that's one can Started taking the Purixa on July, 16 2013 after taking almost this one month supply today August 07, 2013 1 can say nothing but good things about it

      I personally would highly recommend Purixa for its extraordinary healing for me, to anyone to try who needs to lower uric acid levels. I could see a great improvement in only 3 - 8oz glasses of this product. I can cleary see that this stuff worked for me as the tophi is no longer coming out thru the skin. The places are healing up very fast and the pain is also gone. It has helped my problem with this tophi coming out of my body.

      I can tell it is cleaning other parts of my body as lam now aching at night think it's the crystals are braking up. And I hope it is helping my only kidney stay clean of tophi.....I'll know more on this when I go in for my next kidney check-up.

      I already know drinking plenty of Water will help as it helps your kidney's flush more efficiently and it won't have to work as hard to get the uric acid out, and they will thank you if you have one or two kidneys.

      I have ordered a Uric Acid Meter. It came on August, 5 2013 and I took two tests hours apart 9.5 so I am also shedding the uric acid in my blood as well. Started with 10.9 uric acid level.

      I believe one can avoid a lot of problems by lowering uric acid naturally and eliminating gout problems with safe and effective alternatives with no side affects as I am doing with your Purixa..

      Thank you for a great product it has helped me in reaching my goals of lowering my uric acid and removing the tophi. Only wish I had found this two or more years ago.

      I also use oddball cures and diet for my Diabetes Aic is now at a 5, for the last 4-5 years Blood pressure is 118-67-68 on most days. With no medicines at all. Just supplements and exercise, and diet. just look at the numbers.

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      Leona 3 years ago

      I found PURIXA after trying another natural supplement that didn't work for me. I have tried Allopurinol and Uloric with success, but they had unacceptable side effects.

      I take PURIXA once a day, and it has brought my UA down from 11.2 to 6.5 and sometimes if I'm a good girl, lower than that.

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      Mark ok 3 years ago

      Purixa is simply the best natural remedy for gout relief! I have been using Purixa now for nearly the past year with outstanding results. Prior to this I had tried numerous gout reducing products which claimed or promised to eliminate or reduce my gout symptoms. Many spent and wasted dollars later, those products (pill variations) provided no relief for my gout related symptoms. Upon my first try of Purixa, the general aches, and pains caused by my gout had immediately subsided. I had the best night's rest in years and it continues today. I cannot stress this fact, that the results were impacted the same evening I used this product.(No placebo effect here.) Since that time with diet changes and continued use of Purixa, I continue to live gout free and my gout symptoms have not returned. Thank you Purixa. MarkO

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      Cory Shutts 3 years ago

      I have been using Purixa for about a month and there isn't any way to put into words how much better my feet feel. I'm not actually sure that the Purixa is lowering my uric acid, but I do know that it is helping me feel better!

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      The Boss 3 years ago

      Purixa is one of the best products on the market. I have been using it for about 3 months and haven't had any tingles or flare ups to mention!!! Great Product!!!

    • profile image

      Sweet Deal 3 years ago

      This truly is one of the greatest gout products ever! Have been using it for a few months and no flare ups and my toes are the least stiff in the longest time that I can remember.

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      Robert 3 years ago

      I am very pleased with the Purixa product. All the redness and swelling in the toe joint, and I mean all, has vanished in one week since taking it. I took a chance on the product when my podiatrist confirmed that caseine, which Purixa has, does eliminate uric acid buildup, and that studies existed writing about this. He showed me in his office this one site on the caseine study, which I submit below:

      tp://ajcn.nutrition.org/content/53/3/665.abstract

      I am encouraged that Purixa has no chemicals or drugs in it, because they can have liver and kidney side-effects. At my age, it's the last thing I need to worry about.

      Purixa does work. I am genuinely surprised at how quickly the redness in the toe joint disappeared, and have ordered three more bottles (discount pricing) from Purixa. I do not want to ever go through this gout pain again-- it hurts terribly. To ward off future attacks I am banking on Purixa.

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      Neil - UK 3 years ago

      I've now been using Purixa for 2 months and can honestly say that it works!

      My uric acid levels were 14 before I tried Purixa and now they're 7 and dropping!

      I contracted a rare, life threatening, tropical disease in Africa 7 years ago whilst volunteering at a primate rescue sanctuary and, although that is now gone I have been left with high uric acid and gout as a result.

      My gout flare ups have been sporadic but severe and appear in my knees, wrist, finger or elbow - I never know where it will be - and so I was constantly worrying about spending the rest of my life with the threat of flare ups hanging over me.

      It's such a relief that Purixa works and I can be confident that with continued use and a sensible diet I can enjoy life gout free.

      I'd also like to thank the Purixa team for their outstanding customer service - so rare these days!

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      yancey 3 years ago

      i have been taking purixa for three weeks and have not had a breakout ...i was having them almost constantly and taking indicin which seemed to stop working...thanks

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      vararp@hotmail.com 3 years ago

      I have pain on my left leg thumb yesterday on wards. Having difficult to walk. I hope it may be uric acid problem.

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      Matt 3 years ago

      I have been using Purixa for about 3 months now. I haven't had my uric acid tested lately, but I have not had a gout flare up since I started taking this product. I really did/do not want to take a prescription for the rest of my life so I have tried all of the home remedies to relieve gout and nothing even came close to working.

      I have had a few tingles now and then in joints that have had gout before, but that is where they stop. I firmly believe that would have resulted in a full blown attack if I weren't taking Purixa so I believe that it works. One drawback: I take 2 - 3 scoops per day so it is a little expensive when a bottle doesn't even last a month.

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      EDWIN ESCOBAR 3 years ago

      I have been using PURIXA for more than 3 months. Rapid response

      with low purine diet. Very effective in UA levels. No secondary effects.

      No residual joint pains or tenderness. I recommend this product.

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      Craig in Norwalk CT 3 years ago

      I had started using Purixa about one year ago. It has been effective for me. The first ten days of use , I had some discomfort in my left big toe joint. I was assuming this was the uric acid beginning to go into solution to leave the joint. It has since cut gout flares I would say 75% for me and when a flare happens it is much less severe. Mostly just a little soreness now compared to major pain in the past. I truly feel the Purixa has made a huge difference, or I would not have stuck with it for a year. Thank you Purixa.......

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      Ozzy Alex 2 years ago

      I have been using Purixa for about 2 months now at a dosage of about 1/2 a scoop a day. I haven't had any more gout attacks since then but still have occasional foot and ankle soreness. My uric acid and urea levels have dropped about 10% each and are now back in the normal range. I have also resumed eating red meat and drinking wine once a week.

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      Linda 2 years ago

      My husband has suffered from frequent cases of gout for the past ten years. He is heavy and often a beer drinker but since I came upon purixa he has not suffered any gout attacks . He is sold on your product and tells everyone he knows about it . Thank you Linda

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