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My Iron Infusions - Switching from Dextran to Venofer

Updated on September 6, 2014
photo of "Hospital Hand" by Kim McLeod used with permission.
photo of "Hospital Hand" by Kim McLeod used with permission.

My Infusions

Hi. I'm Kay. For the last ten years or so, I've been struggling with iron deficiency anemia.

When I say iron deficiency anemia, I mean that I just have no iron in my body and diets and supplements do not seem to help much. I've been undergoing infusions for more than awhile now and would like to share a bit of my own experiences in hopes that it helps somebody else with their own infusions. During my second round of infusions, I had a bad reaction to the Dextran, For the next set of infusions, my hematologist swithced me to Venofer. While I've written about my Dextran reactions, this page details my experience, so far, with the Venofer.

What is an Iron Infusion?

I know that not everybody who reads this page will be familiar with iron infusions so let me *introduce* you to the infusion process.

Once it has been determined that you are anemic, doctors may prescribe iron pills and recommend changing your eating habits. If these things don't work or cause side effects and your iron levels are dangerously low, they may then order a series of infusions.

An infusion is iron in liquid form and it is given through an IV. Each infusion may take one to three (or so) hours depending upon the type of iron and dosage. This is given in a doctor's office or hospital setting and you are monitored during the procedure.

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Which Brings Us to My Venofer Infusions:

After my severe reaction to Dextran, my doctor decided to wait until it was absolutely necessary to have another infusion. Four months later, it was necessary. I had only had one infusion during that round before I had the side effects so my ferritin never got really high. I knew it was about time. Again, I was just tired all the time.

Near the end of November, we discovered that, again, my ferritin levels were below five. I was a mite nervous about scheduling another infusion but they told me they'd switch to Venofer which is better tolerated and has far fewer side effects.

So, I suppose, like me, you are wondering, if it has fewer side effects, WHY DIDN'T THEY START WITH THAT ONE? Well, I asked that question. I was told that Venofer is more expensive and insurance companies prefer to start with the cheaper Dextran.

I was told that rather than two infusions with Dextran, I would now have five infusions (one each week) and they would be shorter in duration.

Have you had an iron infusion? (would love to hear about your experience)

See results
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My First Venofer Infusion

I was scheduled for my first Venofer infusion toward the end of November. I had been given Benadryl prior to my other infusions so I was prepared. I had my pillow and was even looking forward to a little nap. The nurse brought over my Venofer bag and I didn't see the Benadryl. I was a bit concerned because I really did not want to have another bad reaction. She assured me that she has never seen a bad reaction to Venofer and it really is better tolerated than Dextran. I'm skeptical but made sure I was sitting close to the nurse's station. Once the bag was hooked up, it took about an hour and fifteen minutes to finish. The only side effect I had at that time was a bit of itchiness around the IV site. I didn't even have the usual stomach pains that I had with the Dextran. I wasn't groggy a bit because I hadn't had Benadryl. I spent the time conversing with another gal who had had the Benedryl. She was slurring her words and really tired but we had a good conversation about our upcoming Christmas plans.

I drove myself home and for the next hour or so just felt like cleaning, so I did. Several hours later, though, I became really, really, really tired. Far more than I usually am with my anemia and I started getting the flu-like achiness. By that evening, my fever was about 100 and, after taking some Motrin, I was in bed for the night by about 7pm. For the next two days, I would feel fine and then I'd start getting a slight fever with achiness. During those times, I'd nap and wake up feeling better again. All in all, this was much easier than with the other infusions I had had.

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My Second Infusion

We had to reschedule my appointment so I ended up having my second infusion two weeks after the first. This time, I left the pillow at home and brought my laptop. Again, the only side effect that I recall having is itchiness around the IV site. Maybe it isn't the iron and just the IV? Who knows. Anyhow, the time went quickly. I was in and out within an hour and a half.

I was prepared that evening to feel fluish but never happened. I was tired. Yes, I was really tired later that afternoon but that was the only side effect. This one was by far the easier infusion I had had. Maybe my body is adjusting?


My Third Infusion

I arrived for my third infusion and, for the first time, felt no nervousness at all! The nurse hooked up my IV and I spent the next hour or so sending emails and playing Settlers of Catan on my computer. I spoke with a couple chemo patients and, again, we talked about Christmas. There was a gal next to me with an iron IV but she slept the entire time. It was clear she had the Dextran. I arrived well after her bag was started and left before it finished. She slept the entire time I was there. Again, I had a little itchiness around the IV site. About 15 minutes before the bag finished, I did start to get a headache but it wasn't too bad.

This time, when I arrived home, I had to take some Motrin for the headache and just slept for about an hour. I was really exhausted again and didn't do much all day other than take occasional naps. My headache was gone after the first nap. I was pretty tired the next day but had no other side effects. I noticed that the day after that, I had a bit more energy than usual. I think the treatments are beginning to work.

My Fourth Infusion

Had my fourth infusion yesterday. I had absolutely no side effects during the infusion at all. I'd have to say, this was the easiest infusion yet. A little tired from it and had a nice nap once I got home. The only side effect I had was when my husband dropped something that made a loud noise, my heart started racing. It took a moment before it normalized. Didn't like that but will mention it to my doctor at the next appointment.

My Fifth Infusion

By the fourth week, I started to feel much better. I had energy. My last infusion went smoothly and my ferritin made it up to the 80 range which was not as good as the Dextran (over 200 with that first round) but considering I had no ferritin just weeks prior, both the doctor and I were quite happy with that level.

Dextran vs. Venofer

my own experiences

Without a doubt, I have had far fewer side effects with the Venofer.

Some of my own side effects with Dextran that happened each time:

- exhaustion

- stomach pains

- itchiness in my arm and on my head and neck during the IV

and side effects that happened but not during every infusion:

- weight gain in the week that would follow the IV

- flu-like symptoms

- fever

- headaches (severe)

- vomiting

My side effects with Venofer that I've had each time:

- some itchiness at the site of the IV

- exhaustion (but much shorter duration than with the Dextran/Benadryl combination)

and side effects that happened but not each time:

- flu-like symptoms

- fever

- headaches (but easily taken care of with Motrin)

More Information

on Dextran vs. Venofer

If you would like to compare Dextran vs. Venofer, I invite you to check out this site: compares the side effects and reactions of the two among hundreds of patients:
Iron Dextran vs. Venofer.

If you'd like to see the side effects for each:

Iron Dextran Side Effects and Reviews

Venofer Side Effects and Reviews.

Just scroll down and click on each one to learn more.

Since writing this page, I've gone through a number of rounds (with five infusions each) of Venofer infusions. They are still so much easier on me. At some point, I will create another page with my most recent experiences. Are you going through this? Please feel free to leave me a message. I'd love to know whether you had Dextran, Venofer, or some other iron drug and how it worked for you. Just knowing there are others undergoing this same treatment is so helpful! I can also be reached at

I'd Love To Hear From You

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    • profile image

      Janine Herr 3 months ago

      I just had my 3rd round of venofer. Thankfully this time they did pre-meds of Benadryl and Tylenol. During my first hour I experience high BP, rapid pulse, tight chest...anyone else experience that?

    • Cari Kay 11 profile image

      Kay 13 months ago

      What did you end up doing for this? The Dextran definitely brought my levels up the quickest and longest but I had such a severe reaction to it, I can't do it again :(

    • profile image

      Kathy Roos 15 months ago

      I've had Dextran for many years and it seemed to work very well. My energy level was very high after a week or so. Now about 2 months ago I had the Venefor (3) regiment. I really never got the energy that I had gotten with the dextran. Plus they can't seem to find a vein and it takes at least 3 try's before it works each time. I feel that I want to go back to Dextran. I'm going to ask my hemotologist when I see him in 1 month. Are there any other options with getting into the site for the infusion?

    • profile image

      Iza 19 months ago

      Hello, thank you for your reply!

      Oh, I wish I knew what they had poured into my veins! I'd better go back there to ask to be sure NOT to have it again. Although to be honest, I am not planning on having another infusion. It makes me feel worse instead of better. I had my blood sample taken today, we will see what the results are like.

      In my case, I blame the periods. I am considering a hysterectomy. For now I will start some hormonal therapy to reduce the bleeding. Oh well.

      Wish all of you lots of good health for 2016!

    • Cari Kay 11 profile image

      Kay 19 months ago

      I am so sorry you are going through this. Wonder if they gave you Dextran? That was really, really tough on me as well. You should start to feel better. It was about week or four or so when I started feeling more like myself of that one. Keep me updated!

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