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When and if you don't enjoy it any longer.
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When you need to. Ask yourself that question and see what the answer is.
Providing that the brain works, never, unless there is a physical problem that can't be overcome. Writers can no more stop writing than actors can stop acting, than painters can stop painting...
If you like it, write forever.
If something inside urges you keep up.
When you get tired. People are likely to make mistakes when they are tired. Rest, and then start again.
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Copyright © 2017 HubPages Inc. and respective owners.